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Multiple sclerosis: general features and pharmacologic approach; Esclerosis multiple: aspectos generales y abordaje farmacologico

Journal Article:

Abstract

Multiple sclerosis is an autoimmune, inflammatory and desmyelinization disease central nervous system (CNS) of unknown etiology and critical evolution. There different etiological hypotheses talking of a close interrelation among predisposing genetic factors and dissimilar environmental factors, able to give raise to autoimmune response at central nervous system level. Hypothesis of autoimmune pathogeny is based on study of experimental models, and findings in biopsies of affected patients by disease. Accumulative data report that the oxidative stress plays a main role in pathogenesis of multiple sclerosis. Oxygen reactive species generated by macrophages has been involved as mediators of demyelinization and of axon damage, in experimental autoimmune encephalomyelitis and strictly in multiple sclerosis. Disease diagnosis is difficult because of there is not a confirmatory unique test. Management of it covers the treatment of acute relapses, disease modification, and symptoms management. These features require an individualized approach, base on evolution of this affection, and tolerability of treatments. In addition to diet, among non-pharmacologic treatments for multiple sclerosis it is recommended physical therapy. Besides, some clinical assays have been performed in which we used natural extracts, nutrition supplements, and other agents with promising results. Pharmacology allowed neurologists with a broad array of proved effectiveness drugs;  More>>
Authors:
Nielsen Lagumersindez, Denis; Martinez Sanchez, Gregorio [1] 
  1. Instituto de Farmacia y Alimentos, Universidad de La Habana, La Habana (Cuba)
Publication Date:
Jul 01, 2009
Product Type:
Journal Article
Resource Relation:
Journal Name: Revista Cubana de Farmacia (Online); Journal Volume: 43; Journal Issue: 2
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOPSY; DIAGNOSIS; EXPERIMENTAL DATA; MACROPHAGES; NERVOUS SYSTEM DISEASES; NUTRITION; RADIOMIMETIC DRUGS; THERAPY
OSTI ID:
21243239
Country of Origin:
Cuba
Language:
Spanish
Other Identifying Numbers:
Journal ID: ISSN 1561-2988; TRN: CU0900144104903
Availability:
Also availbale from: revista cubana de farmacia http://bvs.sld.cu/revistas/far/vol43_2_09/farsu209.htm;INIS
Submitting Site:
INIS
Size:
vp.
Announcement Date:
Dec 23, 2009

Journal Article:

Citation Formats

Nielsen Lagumersindez, Denis, and Martinez Sanchez, Gregorio. Multiple sclerosis: general features and pharmacologic approach; Esclerosis multiple: aspectos generales y abordaje farmacologico. Cuba: N. p., 2009. Web.
Nielsen Lagumersindez, Denis, & Martinez Sanchez, Gregorio. Multiple sclerosis: general features and pharmacologic approach; Esclerosis multiple: aspectos generales y abordaje farmacologico. Cuba.
Nielsen Lagumersindez, Denis, and Martinez Sanchez, Gregorio. 2009. "Multiple sclerosis: general features and pharmacologic approach; Esclerosis multiple: aspectos generales y abordaje farmacologico." Cuba.
@misc{etde_21243239,
title = {Multiple sclerosis: general features and pharmacologic approach; Esclerosis multiple: aspectos generales y abordaje farmacologico}
author = {Nielsen Lagumersindez, Denis, and Martinez Sanchez, Gregorio}
abstractNote = {Multiple sclerosis is an autoimmune, inflammatory and desmyelinization disease central nervous system (CNS) of unknown etiology and critical evolution. There different etiological hypotheses talking of a close interrelation among predisposing genetic factors and dissimilar environmental factors, able to give raise to autoimmune response at central nervous system level. Hypothesis of autoimmune pathogeny is based on study of experimental models, and findings in biopsies of affected patients by disease. Accumulative data report that the oxidative stress plays a main role in pathogenesis of multiple sclerosis. Oxygen reactive species generated by macrophages has been involved as mediators of demyelinization and of axon damage, in experimental autoimmune encephalomyelitis and strictly in multiple sclerosis. Disease diagnosis is difficult because of there is not a confirmatory unique test. Management of it covers the treatment of acute relapses, disease modification, and symptoms management. These features require an individualized approach, base on evolution of this affection, and tolerability of treatments. In addition to diet, among non-pharmacologic treatments for multiple sclerosis it is recommended physical therapy. Besides, some clinical assays have been performed in which we used natural extracts, nutrition supplements, and other agents with promising results. Pharmacology allowed neurologists with a broad array of proved effectiveness drugs; however, results of research laboratories in past years make probable that therapeutical possibilities increase notably in future. (Author)}
journal = {Revista Cubana de Farmacia (Online)}
issue = {2}
volume = {43}
place = {Cuba}
year = {2009}
month = {Jul}
}