Abstract
Statins have become one of the most prescribed drugs in the world. These medications are used in the treatment of dyslipidemia and in the prevention of cardiovascular diseases. Recently, new evidence has emerged about their mechanisms of action and their pleiotropic properties, well beyond lowering cholesterol levels. This pharmacodynamic action has called the attention of many investigators who suggest their use in several diseases centered on inflammation, immune disorders and cell proliferation. Although there is wide evidence that recognizes their efficacy in several disease models, there is still a lack of studies to approve their use in clinical practice. The pharmacodynamic properties focusing on the pathophysiology that suggests their clinical use in the treatment of several diseases have been reviewed. (author) [Spanish] Las estatinas se han convertido en una de las drogas mas prescritas en el mundo. Este tipo de farmacos es utilizado en el tratamiento de la dislipidemia y en la prevencion de la enfermedad cardiovascular. Recientemente, ha surgido nueva evidencia sobre sus mecanismos de accion y son bien conocidas sus propiedades pleiotropicas, mas alla de la disminucion de los niveles de colesterol. Esta caracteristica farmacodinamica ha llamado la atencion de muchos investigadores quienes sugieren su uso en diferentes
More>>
Ramos-Esquivel, Allan;
Leon-Cespedes, Carlos
[1]
- Univ. de Costa Rica, Escuela de Medicina, Dept. de Fisiologia (Costa Rica)
Citation Formats
Ramos-Esquivel, Allan, and Leon-Cespedes, Carlos.
Lipid-lowering effects of statins; Efectos no hipolipemiantes de las estatinas.
Costa Rica: N. p.,
2007.
Web.
Ramos-Esquivel, Allan, & Leon-Cespedes, Carlos.
Lipid-lowering effects of statins; Efectos no hipolipemiantes de las estatinas.
Costa Rica.
Ramos-Esquivel, Allan, and Leon-Cespedes, Carlos.
2007.
"Lipid-lowering effects of statins; Efectos no hipolipemiantes de las estatinas."
Costa Rica.
@misc{etde_21200209,
title = {Lipid-lowering effects of statins; Efectos no hipolipemiantes de las estatinas}
author = {Ramos-Esquivel, Allan, and Leon-Cespedes, Carlos}
abstractNote = {Statins have become one of the most prescribed drugs in the world. These medications are used in the treatment of dyslipidemia and in the prevention of cardiovascular diseases. Recently, new evidence has emerged about their mechanisms of action and their pleiotropic properties, well beyond lowering cholesterol levels. This pharmacodynamic action has called the attention of many investigators who suggest their use in several diseases centered on inflammation, immune disorders and cell proliferation. Although there is wide evidence that recognizes their efficacy in several disease models, there is still a lack of studies to approve their use in clinical practice. The pharmacodynamic properties focusing on the pathophysiology that suggests their clinical use in the treatment of several diseases have been reviewed. (author) [Spanish] Las estatinas se han convertido en una de las drogas mas prescritas en el mundo. Este tipo de farmacos es utilizado en el tratamiento de la dislipidemia y en la prevencion de la enfermedad cardiovascular. Recientemente, ha surgido nueva evidencia sobre sus mecanismos de accion y son bien conocidas sus propiedades pleiotropicas, mas alla de la disminucion de los niveles de colesterol. Esta caracteristica farmacodinamica ha llamado la atencion de muchos investigadores quienes sugieren su uso en diferentes enfermedades que se centran en la inflamacion, en desordenes de la inmunidad y en la proliferacion celular. Aunque hay amplia evidencia que reconoce su eficacia en diversos modelos de enfermedades, todavia existe una falta de estudios que apoyen su uso en la practica clinica. El mecanismo de accion de estos farmacos y de la base fisiopatologica que sugiere su uso clinico en diferentes enfermedades han sido revisados. (autor)}
journal = []
issue = {4}
volume = {49}
place = {Costa Rica}
year = {2007}
month = {Oct}
}
title = {Lipid-lowering effects of statins; Efectos no hipolipemiantes de las estatinas}
author = {Ramos-Esquivel, Allan, and Leon-Cespedes, Carlos}
abstractNote = {Statins have become one of the most prescribed drugs in the world. These medications are used in the treatment of dyslipidemia and in the prevention of cardiovascular diseases. Recently, new evidence has emerged about their mechanisms of action and their pleiotropic properties, well beyond lowering cholesterol levels. This pharmacodynamic action has called the attention of many investigators who suggest their use in several diseases centered on inflammation, immune disorders and cell proliferation. Although there is wide evidence that recognizes their efficacy in several disease models, there is still a lack of studies to approve their use in clinical practice. The pharmacodynamic properties focusing on the pathophysiology that suggests their clinical use in the treatment of several diseases have been reviewed. (author) [Spanish] Las estatinas se han convertido en una de las drogas mas prescritas en el mundo. Este tipo de farmacos es utilizado en el tratamiento de la dislipidemia y en la prevencion de la enfermedad cardiovascular. Recientemente, ha surgido nueva evidencia sobre sus mecanismos de accion y son bien conocidas sus propiedades pleiotropicas, mas alla de la disminucion de los niveles de colesterol. Esta caracteristica farmacodinamica ha llamado la atencion de muchos investigadores quienes sugieren su uso en diferentes enfermedades que se centran en la inflamacion, en desordenes de la inmunidad y en la proliferacion celular. Aunque hay amplia evidencia que reconoce su eficacia en diversos modelos de enfermedades, todavia existe una falta de estudios que apoyen su uso en la practica clinica. El mecanismo de accion de estos farmacos y de la base fisiopatologica que sugiere su uso clinico en diferentes enfermedades han sido revisados. (autor)}
journal = []
issue = {4}
volume = {49}
place = {Costa Rica}
year = {2007}
month = {Oct}
}