The aim of this project was to unravel the role that miR-221 and miR-222, of which we had already demonstrated the specific differential expression in glioblastoma multiforme compared to normal brain, play in the control of cell proliferation, with the ultimate goal to provide new insights in the molecular basis of cancer. The results of our research allowed to identify an important molecular target for miRNA-221 and miR-222, highly expressed in glioblastoma multiforme tissues and cell lines, and to precisely recognize the mRNA regions responsible for this regulation.
Farace, M G;  Finocchiaro, G;  Ricci Vitiani, L 
- Department Experimental Medicine and Biochemical Sciences, University of Tor Vergata, Rome (Italy)
- Istituto Neurologico Besta, Milan (Italy)
- Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome (Italy)