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Contribution of new cytogenetic techniques in the estimations of old irradiations in retrospective biological dosimetry; Apport des nouvelles techniques de cytogenetiques dans l'estimation des irradiations anciennes en dosimetrie biologique retrospective

Abstract

The objective of this study was to answer three questions: if the translocations are steady: the results have shown that the translocations even if they are not obligatory steady can be used in retrospective dosimetry. Furthermore, it appeared important to consider the complex translocations in view of their relative stability and complementary information they bring ( quality of radiation, received dose). The second question is what contribution of the M-F.I.S.H. in the translocations analysis in comparison with the F.I.S.H.-3: we have shown that the M-F.I.S.H. would allow to raise the whole of doubt due to a partial genome observation. that has for effect to increase the precision of the analysis and that what ever be the received dose. The third question is if there are differences between the chromosomal aberrations generated by x radiation of 50 keV and by gamma radiation from cobalt-60: yes, the low energy photons generate more translocations than the photons coming from cobalt-60. But they generate less dicentrics. this difference comes from the way the energy is deposited that leads to a more important formation of complex and multiple translocations with the low energy photons. this could constitute a problem in the use of low energy  More>>
Authors:
Publication Date:
Oct 15, 2007
Product Type:
Thesis/Dissertation
Report Number:
FRNC-TH-7620
Resource Relation:
Other Information: TH: These cancerologie; Also available from: Bibliotheque Universitaire de Medecine, 63 Rue Gabriel Peri, 94276 - Le Kremlin-Bicetre CEDEX (France)
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHROMOSOMAL ABERRATIONS; DICENTRIC CHROMOSOMES; DOSIMETRY; IRRADIATION; LYMPHOPENIA; NUCLEAR MEDICINE; RADIATION ACCIDENTS; TRANSLOCATION
OSTI ID:
21190195
Research Organizations:
Paris-11 Univ., 91 - Orsay (France)
Country of Origin:
France
Language:
French
Other Identifying Numbers:
TRN: FR0900770062474
Availability:
Available from INIS in electronic form
Submitting Site:
FRN
Size:
163 pages
Announcement Date:
Aug 15, 2009

Citation Formats

Pouzoulet, F. Contribution of new cytogenetic techniques in the estimations of old irradiations in retrospective biological dosimetry; Apport des nouvelles techniques de cytogenetiques dans l'estimation des irradiations anciennes en dosimetrie biologique retrospective. France: N. p., 2007. Web.
Pouzoulet, F. Contribution of new cytogenetic techniques in the estimations of old irradiations in retrospective biological dosimetry; Apport des nouvelles techniques de cytogenetiques dans l'estimation des irradiations anciennes en dosimetrie biologique retrospective. France.
Pouzoulet, F. 2007. "Contribution of new cytogenetic techniques in the estimations of old irradiations in retrospective biological dosimetry; Apport des nouvelles techniques de cytogenetiques dans l'estimation des irradiations anciennes en dosimetrie biologique retrospective." France.
@misc{etde_21190195,
title = {Contribution of new cytogenetic techniques in the estimations of old irradiations in retrospective biological dosimetry; Apport des nouvelles techniques de cytogenetiques dans l'estimation des irradiations anciennes en dosimetrie biologique retrospective}
author = {Pouzoulet, F}
abstractNote = {The objective of this study was to answer three questions: if the translocations are steady: the results have shown that the translocations even if they are not obligatory steady can be used in retrospective dosimetry. Furthermore, it appeared important to consider the complex translocations in view of their relative stability and complementary information they bring ( quality of radiation, received dose). The second question is what contribution of the M-F.I.S.H. in the translocations analysis in comparison with the F.I.S.H.-3: we have shown that the M-F.I.S.H. would allow to raise the whole of doubt due to a partial genome observation. that has for effect to increase the precision of the analysis and that what ever be the received dose. The third question is if there are differences between the chromosomal aberrations generated by x radiation of 50 keV and by gamma radiation from cobalt-60: yes, the low energy photons generate more translocations than the photons coming from cobalt-60. But they generate less dicentrics. this difference comes from the way the energy is deposited that leads to a more important formation of complex and multiple translocations with the low energy photons. this could constitute a problem in the use of low energy photons in radiotherapy. it would seem that the simple translocations rate is not influenced by the photons energy. (N.C.)}
place = {France}
year = {2007}
month = {Oct}
}