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Development of a liquid xenon Compton telescope dedicated to functional medical imaging; Etude et developpement d'un telescope compton au xenon liquide dedie a l'imagerie medicale fonctionnelle

Abstract

Functional imaging is a technique used to locate in three dimensions the position of a radiotracer previously injected in a patient. The two main modalities used for a clinical application to detect tumors, the SPECT and the PET, use solid scintillators as a detection medium. The objective of this thesis was to investigate the possibility of using liquid xenon in order to benefit from the intrinsic properties of this medium in functional imaging. The feasibility study of such a device has been performed by taking into account the technical difficulties specific to the liquid xenon. First of all, simulations of a liquid xenon PET has been performed using Monte-Carlo methods. The results obtained with a large liquid xenon volume are promising : we can expect a reduction of the injected activity of radiotracer, an improvement of the spatial resolution of the image and a parallax free camera. The second part of the thesis was focused on the development of a new concept of medical imaging, the three gamma imaging, based on the use of a new emitter: the 44 scandium. Associated to a classical PET camera, the Compton telescope is used to infer the incoming direction of the third gamma  More>>
Authors:
Publication Date:
Dec 15, 2007
Product Type:
Thesis/Dissertation
Report Number:
FRNC-TH-7560
Resource Relation:
Other Information: TH: These Discipline: physique nucleaire. Specialite: physique subatomique et applications; 80 refs.; Also available from Bibliotheque universitaire - Section Sciences et techniques, 2 rue de la Houssiniere BP 82207, 44322 - Nantes Cedex 03 (France)
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; FEASIBILITY STUDIES; LIQUID SCINTILLATORS; PHOTON COMPUTED TOMOGRAPHY; POSITRON COMPUTED TOMOGRAPHY; XENON
OSTI ID:
21182837
Research Organizations:
Nantes Univ., Faculte des Sciences et Techniques, 44 (France)
Country of Origin:
France
Language:
French
Other Identifying Numbers:
TRN: FR0801985057097
Availability:
Available from INIS in electronic form
Submitting Site:
FRN
Size:
182 pages
Announcement Date:
Jul 17, 2009

Citation Formats

Grignon, C. Development of a liquid xenon Compton telescope dedicated to functional medical imaging; Etude et developpement d'un telescope compton au xenon liquide dedie a l'imagerie medicale fonctionnelle. France: N. p., 2007. Web.
Grignon, C. Development of a liquid xenon Compton telescope dedicated to functional medical imaging; Etude et developpement d'un telescope compton au xenon liquide dedie a l'imagerie medicale fonctionnelle. France.
Grignon, C. 2007. "Development of a liquid xenon Compton telescope dedicated to functional medical imaging; Etude et developpement d'un telescope compton au xenon liquide dedie a l'imagerie medicale fonctionnelle." France.
@misc{etde_21182837,
title = {Development of a liquid xenon Compton telescope dedicated to functional medical imaging; Etude et developpement d'un telescope compton au xenon liquide dedie a l'imagerie medicale fonctionnelle}
author = {Grignon, C}
abstractNote = {Functional imaging is a technique used to locate in three dimensions the position of a radiotracer previously injected in a patient. The two main modalities used for a clinical application to detect tumors, the SPECT and the PET, use solid scintillators as a detection medium. The objective of this thesis was to investigate the possibility of using liquid xenon in order to benefit from the intrinsic properties of this medium in functional imaging. The feasibility study of such a device has been performed by taking into account the technical difficulties specific to the liquid xenon. First of all, simulations of a liquid xenon PET has been performed using Monte-Carlo methods. The results obtained with a large liquid xenon volume are promising : we can expect a reduction of the injected activity of radiotracer, an improvement of the spatial resolution of the image and a parallax free camera. The second part of the thesis was focused on the development of a new concept of medical imaging, the three gamma imaging, based on the use of a new emitter: the 44 scandium. Associated to a classical PET camera, the Compton telescope is used to infer the incoming direction of the third gamma ray by triangulation. Therefore, it is possible to reconstruct the position of each emitter in three dimensions. This work convinced the scientific community to support the construction and characterization of a liquid xenon Compton telescope. The first camera dedicated to small animal imaging should then be operational in 2009. (author)}
place = {France}
year = {2007}
month = {Dec}
}