Abstract
Purpose: To evaluate the risk factors for acute esophagitis (AET) in lung cancer patients treated with concurrent 3D-CRT and chemotherapy. Methods and Materials: Data from 100 patients treated with concurrent chemoradiotherapy with a mean dose of 62.05 {+-} 4.64 Gy were prospectively evaluated. Esophageal toxicity was graded according to criteria of the Radiation Therapy Oncology Group. The following dosimetric parameters were analyzed: length and volume of esophagus in treatment field, percentage of esophagus volume treated to {>=}10, {>=}20, {>=}30, {>=}35, {>=}40, {>=}45, {>=}50, {>=}55, and {>=}60 Gy, and the maximum (D{sub max}) and mean doses (D{sub mean}) delivered to the esophagus. Also, we developed an esophagitis index (EI) to account the esophagitis grades over treatment time. Results: A total of 59 patients developed AET (Grade 1, 26 patients; Grade 2, 29 patients; and Grade 3, 4 patients). V50 was associated with AET duration (p = 0.017), AET Grade 1 duration (p = 0.016), maximum analgesia (p = 0.019), esophagitis index score (p = 0.024), and AET Grade {>=}1 (p = 0.058). If V50 is <30% there is a 47.3% risk of AET Grade {>=}1, which increases to 73.3% if V50 is {>=}30% (p = 0.008). The predictive abilities of models
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Rodriguez, Nuria;
[1]
Department of Medicine, Universitat Autonoma de Barcelona, Barcelona (Spain)], E-mail: nrodriguez@imas.imim.es;
Algara, Manuel;
[1]
Universitat Pompeu Fabra, Barcelona (Spain)];
Foro, Palmira;
[1]
Lacruz, Marti;
[1]
Universitat Pompeu Fabra, Barcelona (Spain)];
Reig, Anna;
Membrive, Ismael;
Lozano, Joan;
Lopez, Jose Luis;
[1]
Quera, Jaime;
[1]
Universitat Pompeu Fabra, Barcelona (Spain)];
Fernandez-Velilla, Enric;
Sanz, Xavier
[1]
- Department of Radiation Oncology, Hospital de la Esperanza, IMAS, Barcelona (Spain)
Citation Formats
Rodriguez, Nuria, Department of Medicine, Universitat Autonoma de Barcelona, Barcelona (Spain)], E-mail: nrodriguez@imas.imim.es, Algara, Manuel, Universitat Pompeu Fabra, Barcelona (Spain)], Foro, Palmira, Lacruz, Marti, Universitat Pompeu Fabra, Barcelona (Spain)], Reig, Anna, Membrive, Ismael, Lozano, Joan, Lopez, Jose Luis, Quera, Jaime, Universitat Pompeu Fabra, Barcelona (Spain)], Fernandez-Velilla, Enric, and Sanz, Xavier.
Predictors of Acute Esophagitis in Lung Cancer Patients Treated With Concurrent Three-Dimensional Conformal Radiotherapy and Chemotherapy.
United States: N. p.,
2009.
Web.
doi:10.1016/j.ijrobp.2008.04.064.
Rodriguez, Nuria, Department of Medicine, Universitat Autonoma de Barcelona, Barcelona (Spain)], E-mail: nrodriguez@imas.imim.es, Algara, Manuel, Universitat Pompeu Fabra, Barcelona (Spain)], Foro, Palmira, Lacruz, Marti, Universitat Pompeu Fabra, Barcelona (Spain)], Reig, Anna, Membrive, Ismael, Lozano, Joan, Lopez, Jose Luis, Quera, Jaime, Universitat Pompeu Fabra, Barcelona (Spain)], Fernandez-Velilla, Enric, & Sanz, Xavier.
Predictors of Acute Esophagitis in Lung Cancer Patients Treated With Concurrent Three-Dimensional Conformal Radiotherapy and Chemotherapy.
United States.
https://doi.org/10.1016/j.ijrobp.2008.04.064
Rodriguez, Nuria, Department of Medicine, Universitat Autonoma de Barcelona, Barcelona (Spain)], E-mail: nrodriguez@imas.imim.es, Algara, Manuel, Universitat Pompeu Fabra, Barcelona (Spain)], Foro, Palmira, Lacruz, Marti, Universitat Pompeu Fabra, Barcelona (Spain)], Reig, Anna, Membrive, Ismael, Lozano, Joan, Lopez, Jose Luis, Quera, Jaime, Universitat Pompeu Fabra, Barcelona (Spain)], Fernandez-Velilla, Enric, and Sanz, Xavier.
2009.
"Predictors of Acute Esophagitis in Lung Cancer Patients Treated With Concurrent Three-Dimensional Conformal Radiotherapy and Chemotherapy."
United States.
https://doi.org/10.1016/j.ijrobp.2008.04.064.
@misc{etde_21172633,
title = {Predictors of Acute Esophagitis in Lung Cancer Patients Treated With Concurrent Three-Dimensional Conformal Radiotherapy and Chemotherapy}
author = {Rodriguez, Nuria, Department of Medicine, Universitat Autonoma de Barcelona, Barcelona (Spain)], E-mail: nrodriguez@imas.imim.es, Algara, Manuel, Universitat Pompeu Fabra, Barcelona (Spain)], Foro, Palmira, Lacruz, Marti, Universitat Pompeu Fabra, Barcelona (Spain)], Reig, Anna, Membrive, Ismael, Lozano, Joan, Lopez, Jose Luis, Quera, Jaime, Universitat Pompeu Fabra, Barcelona (Spain)], Fernandez-Velilla, Enric, and Sanz, Xavier}
abstractNote = {Purpose: To evaluate the risk factors for acute esophagitis (AET) in lung cancer patients treated with concurrent 3D-CRT and chemotherapy. Methods and Materials: Data from 100 patients treated with concurrent chemoradiotherapy with a mean dose of 62.05 {+-} 4.64 Gy were prospectively evaluated. Esophageal toxicity was graded according to criteria of the Radiation Therapy Oncology Group. The following dosimetric parameters were analyzed: length and volume of esophagus in treatment field, percentage of esophagus volume treated to {>=}10, {>=}20, {>=}30, {>=}35, {>=}40, {>=}45, {>=}50, {>=}55, and {>=}60 Gy, and the maximum (D{sub max}) and mean doses (D{sub mean}) delivered to the esophagus. Also, we developed an esophagitis index (EI) to account the esophagitis grades over treatment time. Results: A total of 59 patients developed AET (Grade 1, 26 patients; Grade 2, 29 patients; and Grade 3, 4 patients). V50 was associated with AET duration (p = 0.017), AET Grade 1 duration (p = 0.016), maximum analgesia (p = 0.019), esophagitis index score (p = 0.024), and AET Grade {>=}1 (p = 0.058). If V50 is <30% there is a 47.3% risk of AET Grade {>=}1, which increases to 73.3% if V50 is {>=}30% (p = 0.008). The predictive abilities of models (sensitivity and specificity) were calculated by receiver operating characteristic curves. Conclusions: According to the receiver operating characteristic curve analysis, the 30% of esophageal volume receiving {>=}50 Gy was the most statistically significant factor associated with AET Grade {>=}1 and maximum analgesia (A{sub max}). There was an association with AET Grade {>=}2 but it did not achieve statistical significance (p = 0.076)}
doi = {10.1016/j.ijrobp.2008.04.064}
journal = []
issue = {3}
volume = {73}
place = {United States}
year = {2009}
month = {Mar}
}
title = {Predictors of Acute Esophagitis in Lung Cancer Patients Treated With Concurrent Three-Dimensional Conformal Radiotherapy and Chemotherapy}
author = {Rodriguez, Nuria, Department of Medicine, Universitat Autonoma de Barcelona, Barcelona (Spain)], E-mail: nrodriguez@imas.imim.es, Algara, Manuel, Universitat Pompeu Fabra, Barcelona (Spain)], Foro, Palmira, Lacruz, Marti, Universitat Pompeu Fabra, Barcelona (Spain)], Reig, Anna, Membrive, Ismael, Lozano, Joan, Lopez, Jose Luis, Quera, Jaime, Universitat Pompeu Fabra, Barcelona (Spain)], Fernandez-Velilla, Enric, and Sanz, Xavier}
abstractNote = {Purpose: To evaluate the risk factors for acute esophagitis (AET) in lung cancer patients treated with concurrent 3D-CRT and chemotherapy. Methods and Materials: Data from 100 patients treated with concurrent chemoradiotherapy with a mean dose of 62.05 {+-} 4.64 Gy were prospectively evaluated. Esophageal toxicity was graded according to criteria of the Radiation Therapy Oncology Group. The following dosimetric parameters were analyzed: length and volume of esophagus in treatment field, percentage of esophagus volume treated to {>=}10, {>=}20, {>=}30, {>=}35, {>=}40, {>=}45, {>=}50, {>=}55, and {>=}60 Gy, and the maximum (D{sub max}) and mean doses (D{sub mean}) delivered to the esophagus. Also, we developed an esophagitis index (EI) to account the esophagitis grades over treatment time. Results: A total of 59 patients developed AET (Grade 1, 26 patients; Grade 2, 29 patients; and Grade 3, 4 patients). V50 was associated with AET duration (p = 0.017), AET Grade 1 duration (p = 0.016), maximum analgesia (p = 0.019), esophagitis index score (p = 0.024), and AET Grade {>=}1 (p = 0.058). If V50 is <30% there is a 47.3% risk of AET Grade {>=}1, which increases to 73.3% if V50 is {>=}30% (p = 0.008). The predictive abilities of models (sensitivity and specificity) were calculated by receiver operating characteristic curves. Conclusions: According to the receiver operating characteristic curve analysis, the 30% of esophageal volume receiving {>=}50 Gy was the most statistically significant factor associated with AET Grade {>=}1 and maximum analgesia (A{sub max}). There was an association with AET Grade {>=}2 but it did not achieve statistical significance (p = 0.076)}
doi = {10.1016/j.ijrobp.2008.04.064}
journal = []
issue = {3}
volume = {73}
place = {United States}
year = {2009}
month = {Mar}
}