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Diffusion tensor imaging and three-dimensional brain fiber tracking for the diagnosis of multiple sclerosis

Journal Article:

Abstract

Objective: To demonstrate the diffusion tensor imaging (DTI) characteristics of multiple sclerosis (MS) plaques, periplaque white matter regions and normal appearing white matter (NAWM) regions in patients with MS, and to evaluate the clinical values of DTI and three-dimensional brain fiber tracking for the diagnosis of MS. Methods: Conventional MRI and DTI were performed in 32 patients with MS and 32 age-matched control subjects. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) maps were generated and coregistered with T{sub 2}-weighted MR images. FA and ADC values were calculated in regions of interest in plaques, periplaque white matter regions, NAWM regions and white matter regions in control subjects. And three-dimensional brain fiber tracking maps were generated by using the DTI. Results: The ADC was (1.233 {+-} 0.119) x 10{sup -3} mm{sup 2}/s in MS plaques, (0.973 {+-} 0.098) x 10{sup -3} mm{sup 2}/s in periplaque white matter regions, (0.748 {+-} 0.089) x 10{sup -3} mm{sup 2}/s in NAWM, and (0.620 {+-} 0.094) x 10{sup -3} mm{sup 2}/s in control subjects. The FA was 0.225 {+-} 0.052 in MS plaques, 0.311 {+-} 0.050 in periplaque white matter regions, 0.421 {+-} 0.070 in NAWM, and 0.476 {+-} 0.069 in control subjects. Significant differences  More>>
Authors:
Bing, Hu; Hong, Shan; Mingyue, Luo; Shaoqiong, Chen; Wang, Kang; Bingjun, He; Yan, Zou; [1]  Binbin, Ye
  1. Department of Radiology, the 3rd Affiliated Hospital of Sun Yat-sen Univ., Guangzhou (China)
Publication Date:
Feb 15, 2007
Product Type:
Journal Article
Resource Relation:
Journal Name: Chinese Journal of Radiology; Journal Volume: 41; Journal Issue: 2; Other Information: 6 figs., 4 tabs., 19 refs
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANISOTROPY; BRAIN; CENTRAL NERVOUS SYSTEM; DIAGNOSIS; DIFFUSION; EVALUATION; FIBERS; IMAGES; MATTER; NERVOUS SYSTEM DISEASES; NMR IMAGING; PATIENTS; TENSORS
OSTI ID:
21164352
Country of Origin:
China
Language:
Chinese
Other Identifying Numbers:
Journal ID: ISSN 1005-1201; CHFSAG; TRN: CN0900948040896
Submitting Site:
INIS
Size:
page(s) 143-147
Announcement Date:
Jun 02, 2009

Journal Article:

Citation Formats

Bing, Hu, Hong, Shan, Mingyue, Luo, Shaoqiong, Chen, Wang, Kang, Bingjun, He, Yan, Zou, and Binbin, Ye. Diffusion tensor imaging and three-dimensional brain fiber tracking for the diagnosis of multiple sclerosis. China: N. p., 2007. Web.
Bing, Hu, Hong, Shan, Mingyue, Luo, Shaoqiong, Chen, Wang, Kang, Bingjun, He, Yan, Zou, & Binbin, Ye. Diffusion tensor imaging and three-dimensional brain fiber tracking for the diagnosis of multiple sclerosis. China.
Bing, Hu, Hong, Shan, Mingyue, Luo, Shaoqiong, Chen, Wang, Kang, Bingjun, He, Yan, Zou, and Binbin, Ye. 2007. "Diffusion tensor imaging and three-dimensional brain fiber tracking for the diagnosis of multiple sclerosis." China.
@misc{etde_21164352,
title = {Diffusion tensor imaging and three-dimensional brain fiber tracking for the diagnosis of multiple sclerosis}
author = {Bing, Hu, Hong, Shan, Mingyue, Luo, Shaoqiong, Chen, Wang, Kang, Bingjun, He, Yan, Zou, and Binbin, Ye}
abstractNote = {Objective: To demonstrate the diffusion tensor imaging (DTI) characteristics of multiple sclerosis (MS) plaques, periplaque white matter regions and normal appearing white matter (NAWM) regions in patients with MS, and to evaluate the clinical values of DTI and three-dimensional brain fiber tracking for the diagnosis of MS. Methods: Conventional MRI and DTI were performed in 32 patients with MS and 32 age-matched control subjects. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) maps were generated and coregistered with T{sub 2}-weighted MR images. FA and ADC values were calculated in regions of interest in plaques, periplaque white matter regions, NAWM regions and white matter regions in control subjects. And three-dimensional brain fiber tracking maps were generated by using the DTI. Results: The ADC was (1.233 {+-} 0.119) x 10{sup -3} mm{sup 2}/s in MS plaques, (0.973 {+-} 0.098) x 10{sup -3} mm{sup 2}/s in periplaque white matter regions, (0.748 {+-} 0.089) x 10{sup -3} mm{sup 2}/s in NAWM, and (0.620 {+-} 0.094) x 10{sup -3} mm{sup 2}/s in control subjects. The FA was 0.225 {+-} 0.052 in MS plaques, 0.311 {+-} 0.050 in periplaque white matter regions, 0.421 {+-} 0.070 in NAWM, and 0.476 {+-} 0.069 in control subjects. Significant differences in FA and ADC values were observed among all white matter regions (P<0.01). MS plaques were demonstrated in three-dimensional brain fiber tracking maps. Conclusion: FA and ADC maps are helpful for the evaluation of all white matter changes of MS. The abnormalities of white matter fiber tracts in MS plaques could be demonstrated in three-dimensional brain fiber tracking maps. (authors)}
journal = {Chinese Journal of Radiology}
issue = {2}
volume = {41}
place = {China}
year = {2007}
month = {Feb}
}