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Radio protective potential of Trigonella Foenum-Graecum seeds extract

Abstract

Ever since the discovery of X-ray and radioactivity at the end of the 19th century, cellular and molecular responses to ionizing radiation exposures have been the central research endeavors in radiation biology. The most striking aspect of the action of the ionizing radiation on biological material of all kinds is the grave damage produced by relatively trivial amounts of absorbed energy. Radiation damage occurs through the formation of free radical and reactive oxygen species in living organisms and these radicals are highly reactive and cause alterations in DNA, membrane and proteins by reacting with nucleotides, lipids and amino acids which is eventually reflected in cellular dysfunctions. The study of plants as modifiers of radiation effects is a relatively new area of research. There are various adaptive changes which a cell invokes to protect itself from radiation induced unhealthy biochemical changes and this can be supported by food supplements such phytochemical rich diets. Herbal medicines i.e. plant products have been considered as an alternative to synthetic compounds due to their better cultural acceptability, better efficacy, less toxicity and better compatibility with human body. Research has proved that the Trigonella foenum-graecum can inhibit the cancer of liver, lower blood cholesterol levels and  More>>
Authors:
Goyal, P K; Chaudhary, Ranu; Jahan, Swafiya; Gupta, Uma [1] 
  1. Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur (India)
Publication Date:
Jul 01, 2007
Product Type:
Journal Article
Resource Relation:
Journal Name: Journal of Medical Physics; Journal Volume: 32; Journal Issue: suppl.; Conference: AMPICON-2007: 28. annual conference of Association of Medical Physicists of India, Srinagar (India), 2-4 Nov 2007
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; CHOLESTEROL; DIABETES MELLITUS; LIVER; MEDICINAL PLANTS; MICE; NEOPLASMS; RADIOPROTECTIVE SUBSTANCES
OSTI ID:
21155507
Country of Origin:
India
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0971-6203; JMPHFE; TRN: IN0900481033509
Submitting Site:
INIS
Size:
page(s) 39
Announcement Date:
May 18, 2009

Citation Formats

Goyal, P K, Chaudhary, Ranu, Jahan, Swafiya, and Gupta, Uma. Radio protective potential of Trigonella Foenum-Graecum seeds extract. India: N. p., 2007. Web.
Goyal, P K, Chaudhary, Ranu, Jahan, Swafiya, & Gupta, Uma. Radio protective potential of Trigonella Foenum-Graecum seeds extract. India.
Goyal, P K, Chaudhary, Ranu, Jahan, Swafiya, and Gupta, Uma. 2007. "Radio protective potential of Trigonella Foenum-Graecum seeds extract." India.
@misc{etde_21155507,
title = {Radio protective potential of Trigonella Foenum-Graecum seeds extract}
author = {Goyal, P K, Chaudhary, Ranu, Jahan, Swafiya, and Gupta, Uma}
abstractNote = {Ever since the discovery of X-ray and radioactivity at the end of the 19th century, cellular and molecular responses to ionizing radiation exposures have been the central research endeavors in radiation biology. The most striking aspect of the action of the ionizing radiation on biological material of all kinds is the grave damage produced by relatively trivial amounts of absorbed energy. Radiation damage occurs through the formation of free radical and reactive oxygen species in living organisms and these radicals are highly reactive and cause alterations in DNA, membrane and proteins by reacting with nucleotides, lipids and amino acids which is eventually reflected in cellular dysfunctions. The study of plants as modifiers of radiation effects is a relatively new area of research. There are various adaptive changes which a cell invokes to protect itself from radiation induced unhealthy biochemical changes and this can be supported by food supplements such phytochemical rich diets. Herbal medicines i.e. plant products have been considered as an alternative to synthetic compounds due to their better cultural acceptability, better efficacy, less toxicity and better compatibility with human body. Research has proved that the Trigonella foenum-graecum can inhibit the cancer of liver, lower blood cholesterol levels and also have an anti-diabetic effect. The whole extract of Trigonella foenum-graecum has been reported to contain several bioactive components such as glucoside, alkaloids, bitter principle crystalline compounds which elicit protection against several stress and pathological conditions by acting through different mechanisms such as antioxidant, stimulation of cell proliferation immunomodulational and anti-inflammatory activity. Therefore, the present study has been undertaken to screen possible radioprotective potential of Trigonella foenum-graecum extract (TFE) against irradiation.}
journal = []
issue = {suppl.}
volume = {32}
place = {India}
year = {2007}
month = {Jul}
}