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Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives

Journal Article:

Abstract

Pterocarpanquinones 8a-c, previously synthesized in our laboratory, and an homologous series of derivatives, compounds 9a-c prepared in this work, were evaluated on breast cancer cells (MCF-7) and on the parasites Leishmania amazonensis and Plasmodium falciparum, in culture. Compounds 8a-c were more potent than 9a-c on tumor cells and Leishmania amazonensis. On the other hand, 9a-c showed to be more active on Plasmodium falciparum. All the compounds studied were bioselective, presenting negligible cytotoxicity against fresh murine lymphocytes and human lymphocytes activated by the mitogen phytohemagglutinin (PHA). (author)
Authors:
Silva, Alcides J.M. da; Netto, Chaquip D; Costa, Paulo R.R.; [1]  Pacienza-Lima, Wallace; Rossi-Bergmann, Bartira; Maurel, Severine; Valentin, Alexis; Costa, Paulo R.R.; [2]  Torres-Santos, Eduardo Caio; [3]  Maurel, Severine; Valentin, Alexis [4] 
  1. Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Nucleo de Pesquisas de Produtos Naturais. Lab. de Quimica Bioorganica
  2. Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Inst. de Biofisica Carlos Chagas Filho
  3. Instituto Oswaldo Cruz, Rio de Janeiro, RJ (Brazil). Lab. de Bioquimica de Tripanosomatideos
  4. Universite Paul Sabatier, Toulouse (France). Faculte de Pharmacie. Pharmacochimie des Substances Naturelles et Pharmacophores Redox
Publication Date:
Jul 01, 2009
Product Type:
Journal Article
Resource Relation:
Journal Name: Journal of the Brazilian Chemical Society; Journal Volume: 20; Journal Issue: 1; Other Information: 29 refs., 13 figs., 2 tabs
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; ACETONE; ALKENES; ARYLATION; CARBON 13; HYDROGEN 1; INFRARED SPECTRA; NAPHTHOLS; NMR SPECTRA; PALLADIUM CHLORIDES; QUINONES; TOXICITY
OSTI ID:
21152867
Country of Origin:
Brazil
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0103-5053; JOCSET; TRN: BR09V0945030942
Availability:
Available from http://www.scielo.br/pdf/jbchs/v20n1/v20n1a26.pdf;INIS
Submitting Site:
BRN
Size:
page(s) 176-182
Announcement Date:
May 16, 2009

Journal Article:

Citation Formats

Silva, Alcides J.M. da, Netto, Chaquip D, Costa, Paulo R.R., Pacienza-Lima, Wallace, Rossi-Bergmann, Bartira, Maurel, Severine, Valentin, Alexis, Costa, Paulo R.R., Torres-Santos, Eduardo Caio, Maurel, Severine, and Valentin, Alexis. Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives. Brazil: N. p., 2009. Web.
Silva, Alcides J.M. da, Netto, Chaquip D, Costa, Paulo R.R., Pacienza-Lima, Wallace, Rossi-Bergmann, Bartira, Maurel, Severine, Valentin, Alexis, Costa, Paulo R.R., Torres-Santos, Eduardo Caio, Maurel, Severine, & Valentin, Alexis. Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives. Brazil.
Silva, Alcides J.M. da, Netto, Chaquip D, Costa, Paulo R.R., Pacienza-Lima, Wallace, Rossi-Bergmann, Bartira, Maurel, Severine, Valentin, Alexis, Costa, Paulo R.R., Torres-Santos, Eduardo Caio, Maurel, Severine, and Valentin, Alexis. 2009. "Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives." Brazil.
@misc{etde_21152867,
title = {Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives}
author = {Silva, Alcides J.M. da, Netto, Chaquip D, Costa, Paulo R.R., Pacienza-Lima, Wallace, Rossi-Bergmann, Bartira, Maurel, Severine, Valentin, Alexis, Costa, Paulo R.R., Torres-Santos, Eduardo Caio, Maurel, Severine, and Valentin, Alexis}
abstractNote = {Pterocarpanquinones 8a-c, previously synthesized in our laboratory, and an homologous series of derivatives, compounds 9a-c prepared in this work, were evaluated on breast cancer cells (MCF-7) and on the parasites Leishmania amazonensis and Plasmodium falciparum, in culture. Compounds 8a-c were more potent than 9a-c on tumor cells and Leishmania amazonensis. On the other hand, 9a-c showed to be more active on Plasmodium falciparum. All the compounds studied were bioselective, presenting negligible cytotoxicity against fresh murine lymphocytes and human lymphocytes activated by the mitogen phytohemagglutinin (PHA). (author)}
journal = {Journal of the Brazilian Chemical Society}
issue = {1}
volume = {20}
place = {Brazil}
year = {2009}
month = {Jul}
}