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Tumor grading of adult astrocytic glioma on MR imaging

Journal Article:

Abstract

The purpose of this study is to determine predictive MR features for grading of astrocytic gliomas and to evaluate the accuracy of MR grading in these tumors. We retrospectively reviewed 135 cases of supratentorial astrocytic gliomas in adult (age > 15 years), all of which were proved by open biopsy. Two observers analysed MR images independently with criteria of margin, edema, mass effect, signal heterogeneity, necrosis, cyst formation, hemorrhage, tumor vascularity, enhancement degree, and enhancement size. The patterns of enhancement were categorized into no, homogeneous, heterogeneous, thin smooth rim, thin irregular rim, and thick irregular rim enhancement patterns. Observers finally diagnosed each case as one of low-grade astrocytoma, anaplastic astrocytoma or glioblastoma multiforme. Statistically significant MR features for grading of these tumors were revealed as necrosis (p < 0.001), edema (0.008), and signal heterogeneity (p < 0.025). When compared with histopathologic grading, MR graded correctly 76%- 77% of cases in two tired system(low-grade astrocytoma versus high-grade astrocytoma), but only 67%-69% of cases in three tiered system(low-grade astrocytoma, anaplastic astrocytoma, glioblastoma multiforme). No contrast enhancement was seen in 45% and 23% of low-grade astrocytoma and anaplastic astrocytoma respectively. Glioblastoma multiforme frequently showed thick irregular rim enhancement (57%), but no enhancement at  More>>
Authors:
Chang, Kee Hyun; Choi, Choong Gon; Han, Moon Hee; Lee, Seon Kyu; [1]  Suh, Jung Ho; [2]  Lee, Ho Kyu; Suh, Dae Chul; [3]  Choi, Kyu Ho; [4]  Byun, Hong Sik; [5]  Choi, Woo Suk [6] 
  1. Seoul National University College of Medicine, Seoul (Korea, Republic of)
  2. Yonsei University College of Medicine, Seoul (Korea, Republic of)
  3. Ulsan University College of Medicine, Seoul (Korea, Republic of)
  4. Catholic University College of Medicine, Seoul (Korea, Republic of)
  5. Korea Cancer Center Hospital, Seoul (Korea, Republic of)
  6. Kyung Hee University College of Medicine, Seoul (Korea, Republic of)
Publication Date:
Sep 15, 1994
Product Type:
Journal Article
Resource Relation:
Journal Name: Journal of the Korean Radiological Society; Journal Volume: 31; Journal Issue: 3; Other Information: 21 refs, 2 figs, 5 tabs
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ADULTS; BIOPSY; BRAIN; CONTRAST MEDIA; GLIOMAS; HISTOLOGY; NMR IMAGING; PATHOLOGY
OSTI ID:
21146090
Country of Origin:
Korea, Republic of
Language:
Korean
Other Identifying Numbers:
Journal ID: ISSN 1738-2637; DBSHAH; TRN: KR0900631025286
Submitting Site:
KRN
Size:
page(s) 377-384
Announcement Date:
Apr 09, 2009

Journal Article:

Citation Formats

Chang, Kee Hyun, Choi, Choong Gon, Han, Moon Hee, Lee, Seon Kyu, Suh, Jung Ho, Lee, Ho Kyu, Suh, Dae Chul, Choi, Kyu Ho, Byun, Hong Sik, and Choi, Woo Suk. Tumor grading of adult astrocytic glioma on MR imaging. Korea, Republic of: N. p., 1994. Web.
Chang, Kee Hyun, Choi, Choong Gon, Han, Moon Hee, Lee, Seon Kyu, Suh, Jung Ho, Lee, Ho Kyu, Suh, Dae Chul, Choi, Kyu Ho, Byun, Hong Sik, & Choi, Woo Suk. Tumor grading of adult astrocytic glioma on MR imaging. Korea, Republic of.
Chang, Kee Hyun, Choi, Choong Gon, Han, Moon Hee, Lee, Seon Kyu, Suh, Jung Ho, Lee, Ho Kyu, Suh, Dae Chul, Choi, Kyu Ho, Byun, Hong Sik, and Choi, Woo Suk. 1994. "Tumor grading of adult astrocytic glioma on MR imaging." Korea, Republic of.
@misc{etde_21146090,
title = {Tumor grading of adult astrocytic glioma on MR imaging}
author = {Chang, Kee Hyun, Choi, Choong Gon, Han, Moon Hee, Lee, Seon Kyu, Suh, Jung Ho, Lee, Ho Kyu, Suh, Dae Chul, Choi, Kyu Ho, Byun, Hong Sik, and Choi, Woo Suk}
abstractNote = {The purpose of this study is to determine predictive MR features for grading of astrocytic gliomas and to evaluate the accuracy of MR grading in these tumors. We retrospectively reviewed 135 cases of supratentorial astrocytic gliomas in adult (age > 15 years), all of which were proved by open biopsy. Two observers analysed MR images independently with criteria of margin, edema, mass effect, signal heterogeneity, necrosis, cyst formation, hemorrhage, tumor vascularity, enhancement degree, and enhancement size. The patterns of enhancement were categorized into no, homogeneous, heterogeneous, thin smooth rim, thin irregular rim, and thick irregular rim enhancement patterns. Observers finally diagnosed each case as one of low-grade astrocytoma, anaplastic astrocytoma or glioblastoma multiforme. Statistically significant MR features for grading of these tumors were revealed as necrosis (p < 0.001), edema (0.008), and signal heterogeneity (p < 0.025). When compared with histopathologic grading, MR graded correctly 76%- 77% of cases in two tired system(low-grade astrocytoma versus high-grade astrocytoma), but only 67%-69% of cases in three tiered system(low-grade astrocytoma, anaplastic astrocytoma, glioblastoma multiforme). No contrast enhancement was seen in 45% and 23% of low-grade astrocytoma and anaplastic astrocytoma respectively. Glioblastoma multiforme frequently showed thick irregular rim enhancement (57%), but no enhancement at all in 8%. We have concluded that necrosis and edema are significant predictive MR features for grading of supratentorial astrocytic gliomas in adult, and MR was correct in 76%-77% of cases for predicting pathologic grading astrocytomas in two tiered system.}
journal = {Journal of the Korean Radiological Society}
issue = {3}
volume = {31}
place = {Korea, Republic of}
year = {1994}
month = {Sep}
}