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Effectiveness of grape seed extract on gamma radiation-induced hazards in albino rats

Abstract

The present study was designed to determine the possible protective effect of grape seed extract (GSE), rich in proanthocyanidins against gamma radiation-induced oxidative stress associated to serum metabolic disorders in the liver, heart and pancreas tissues of rats. Male albino rats received GSE (100 mg/day/Kg body weight), by gavages, for 14 successive days before whole body exposure to 5 Gy gamma radiation (shot dose). Animals were sacrificed 1, 14, and 28 days post radiation exposure. The results showed that in the irradiated group, tissues superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) activities were decreased significantly, while thiobarbituric acid reactive substances (TBARS) content was increased, which was in parallel with significant increases in the activity of serum lactate dehydrogenase (LDH), creatine phosphokinase (CPK), aspartate and alanine aminotransferase (AST and ALT). Hyperglycemia, hyperinsulinaemia, hyperlipidaemia, decreases in red blood cells count (RBCs) count and hemoglobin (Hb) content were also observed in irradiated rats. n the GSE-treated irradiated group, significant increases of SOD, CAT, and GSH-Px activities with significant reduction of TBARS levels were observed in cardiac, liver, and pancreas tissues, in parallel to significant decreases in the activity of serum LDH, CPK, AST, and ALT compared with their corresponding values in the  More>>
Authors:
Abd El Azime, A S [1] 
  1. Radiation Biology Department, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo (Egypt)
Publication Date:
Jul 01, 2008
Product Type:
Thesis/Dissertation
Report Number:
INIS-EG-196
Resource Relation:
Other Information: TH: Thesis(Ph.D.); 24 tab., 28 fig., 221ref
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; ALANINES; AMINOTRANSFERASES; ANIMAL TISSUES; ASPARTIC ACID; BARBITURATES; BLOOD CELLS; BLOOD SERUM; CATALASE; CHOLESTEROL; CREATINE; ENZYMES; GAMMA RADIATION; GLUTATHIONE; GRAPES; HAZARDS; HEART; HEMOGLOBIN; HYPERGLYCEMIA; INSULIN; IONIZING RADIATIONS; LACTATE DEHYDROGENASE; LIVER; METABOLIC ACTIVATION; OXIDATION; PHOSPHOCREATINE; RADICALS; RADIOTHERAPY; RATS; SEEDS; SUPEROXIDE DISMUTASE; WHOLE-BODY IRRADIATION
OSTI ID:
21144274
Research Organizations:
Faculty of Science Ain Shams University (Egypt)
Country of Origin:
Egypt
Language:
English
Other Identifying Numbers:
TRN: EG0900021024274
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
129 pages
Announcement Date:
Apr 09, 2009

Citation Formats

Abd El Azime, A S. Effectiveness of grape seed extract on gamma radiation-induced hazards in albino rats. Egypt: N. p., 2008. Web.
Abd El Azime, A S. Effectiveness of grape seed extract on gamma radiation-induced hazards in albino rats. Egypt.
Abd El Azime, A S. 2008. "Effectiveness of grape seed extract on gamma radiation-induced hazards in albino rats." Egypt.
@misc{etde_21144274,
title = {Effectiveness of grape seed extract on gamma radiation-induced hazards in albino rats}
author = {Abd El Azime, A S}
abstractNote = {The present study was designed to determine the possible protective effect of grape seed extract (GSE), rich in proanthocyanidins against gamma radiation-induced oxidative stress associated to serum metabolic disorders in the liver, heart and pancreas tissues of rats. Male albino rats received GSE (100 mg/day/Kg body weight), by gavages, for 14 successive days before whole body exposure to 5 Gy gamma radiation (shot dose). Animals were sacrificed 1, 14, and 28 days post radiation exposure. The results showed that in the irradiated group, tissues superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) activities were decreased significantly, while thiobarbituric acid reactive substances (TBARS) content was increased, which was in parallel with significant increases in the activity of serum lactate dehydrogenase (LDH), creatine phosphokinase (CPK), aspartate and alanine aminotransferase (AST and ALT). Hyperglycemia, hyperinsulinaemia, hyperlipidaemia, decreases in red blood cells count (RBCs) count and hemoglobin (Hb) content were also observed in irradiated rats. n the GSE-treated irradiated group, significant increases of SOD, CAT, and GSH-Px activities with significant reduction of TBARS levels were observed in cardiac, liver, and pancreas tissues, in parallel to significant decreases in the activity of serum LDH, CPK, AST, and ALT compared with their corresponding values in the irradiated group. Moreover, serum glucose and insulin contents, RBCs count and Hb content were significantly improved in the GSE-treated irradiated rats. Furthermore, the marked increase in serum triglycerides and total cholesterol observed in irradiated rats, along with elevated LDL-C and decreased HDL-C levels were significantly improved in GSE treated rats. In conclusion, the present data demonstrate that GSE through its free radical scavenging and antioxidant properties attenuates ionizing radiation-induced oxidative injury suggesting that it may be a potential dietary supplement to minimize the side effects of radiotherapy.}
place = {Egypt}
year = {2008}
month = {Jul}
}