Abstract
The nuclear receptor PPAR{gamma} is a lipid sensor that regulates lipid metabolism through gene transcription. Inhibition of PPAR{gamma} activity by TNF-{alpha} is involved in pathogenesis of insulin resistance, atherosclerosis, inflammation, and cancer cachexia. PPAR{gamma} activity is regulated by TNF-{alpha} at pre-translational and post-translational levels. Activation of serine kinases including IKK, ERK, JNK, and p38 may be involved in the TNF-regulation of PPAR{gamma}. Of the four kinases, IKK is a dominant signaling molecule in the TNF-regulation of PPAR{gamma}. IKK acts through at least two mechanisms: inhibition of PPAR{gamma} expression and activation of PPAR{gamma} corepressor. In this review article, literature is reviewed with a focus on the mechanisms of PPAR{gamma} inhibition by TNF-{alpha}.
Ye Jianping , E-mail: yej@pbrc.edu
[1]
- Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808 (United States)
Citation Formats
Ye Jianping , E-mail: yej@pbrc.edu.
Regulation of PPAR{gamma} function by TNF-{alpha}.
United States: N. p.,
2008.
Web.
Ye Jianping , E-mail: yej@pbrc.edu.
Regulation of PPAR{gamma} function by TNF-{alpha}.
United States.
Ye Jianping , E-mail: yej@pbrc.edu.
2008.
"Regulation of PPAR{gamma} function by TNF-{alpha}."
United States.
@misc{etde_21143873,
title = {Regulation of PPAR{gamma} function by TNF-{alpha}}
author = {Ye Jianping , E-mail: yej@pbrc.edu}
abstractNote = {The nuclear receptor PPAR{gamma} is a lipid sensor that regulates lipid metabolism through gene transcription. Inhibition of PPAR{gamma} activity by TNF-{alpha} is involved in pathogenesis of insulin resistance, atherosclerosis, inflammation, and cancer cachexia. PPAR{gamma} activity is regulated by TNF-{alpha} at pre-translational and post-translational levels. Activation of serine kinases including IKK, ERK, JNK, and p38 may be involved in the TNF-regulation of PPAR{gamma}. Of the four kinases, IKK is a dominant signaling molecule in the TNF-regulation of PPAR{gamma}. IKK acts through at least two mechanisms: inhibition of PPAR{gamma} expression and activation of PPAR{gamma} corepressor. In this review article, literature is reviewed with a focus on the mechanisms of PPAR{gamma} inhibition by TNF-{alpha}.}
journal = []
issue = {3}
volume = {374}
place = {United States}
year = {2008}
month = {Sep}
}
title = {Regulation of PPAR{gamma} function by TNF-{alpha}}
author = {Ye Jianping , E-mail: yej@pbrc.edu}
abstractNote = {The nuclear receptor PPAR{gamma} is a lipid sensor that regulates lipid metabolism through gene transcription. Inhibition of PPAR{gamma} activity by TNF-{alpha} is involved in pathogenesis of insulin resistance, atherosclerosis, inflammation, and cancer cachexia. PPAR{gamma} activity is regulated by TNF-{alpha} at pre-translational and post-translational levels. Activation of serine kinases including IKK, ERK, JNK, and p38 may be involved in the TNF-regulation of PPAR{gamma}. Of the four kinases, IKK is a dominant signaling molecule in the TNF-regulation of PPAR{gamma}. IKK acts through at least two mechanisms: inhibition of PPAR{gamma} expression and activation of PPAR{gamma} corepressor. In this review article, literature is reviewed with a focus on the mechanisms of PPAR{gamma} inhibition by TNF-{alpha}.}
journal = []
issue = {3}
volume = {374}
place = {United States}
year = {2008}
month = {Sep}
}