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Regulation of PPAR{gamma} function by TNF-{alpha}

Journal Article:

Abstract

The nuclear receptor PPAR{gamma} is a lipid sensor that regulates lipid metabolism through gene transcription. Inhibition of PPAR{gamma} activity by TNF-{alpha} is involved in pathogenesis of insulin resistance, atherosclerosis, inflammation, and cancer cachexia. PPAR{gamma} activity is regulated by TNF-{alpha} at pre-translational and post-translational levels. Activation of serine kinases including IKK, ERK, JNK, and p38 may be involved in the TNF-regulation of PPAR{gamma}. Of the four kinases, IKK is a dominant signaling molecule in the TNF-regulation of PPAR{gamma}. IKK acts through at least two mechanisms: inhibition of PPAR{gamma} expression and activation of PPAR{gamma} corepressor. In this review article, literature is reviewed with a focus on the mechanisms of PPAR{gamma} inhibition by TNF-{alpha}.
Authors:
Ye Jianping , E-mail: yej@pbrc.edu [1] 
  1. Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808 (United States)
Publication Date:
Sep 26, 2008
Product Type:
Journal Article
Resource Relation:
Journal Name: Biochemical and Biophysical Research Communications; Journal Volume: 374; Journal Issue: 3; Other Information: DOI: 10.1016/j.bbrc.2008.07.068; PII: S0006-291X(08)01397-1; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Subject:
60 APPLIED LIFE SCIENCES; ARTERIOSCLEROSIS; GENE REGULATION; GENES; INFLAMMATION; INHIBITION; INSULIN; LIPIDS; METABOLISM; NEOPLASMS; PATHOGENESIS; PHOSPHOTRANSFERASES; RECEPTORS; REVIEWS; SERINE; TRANSCRIPTION
OSTI ID:
21143873
Country of Origin:
United States
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0006-291X; BBRCA9; TRN: US08R2203023786
Availability:
Available from http://dx.doi.org/10.1016/j.bbrc.2008.07.068;INIS
Submitting Site:
INIS
Size:
page(s) 405-408
Announcement Date:
Apr 09, 2009

Journal Article:

Citation Formats

Ye Jianping , E-mail: yej@pbrc.edu. Regulation of PPAR{gamma} function by TNF-{alpha}. United States: N. p., 2008. Web.
Ye Jianping , E-mail: yej@pbrc.edu. Regulation of PPAR{gamma} function by TNF-{alpha}. United States.
Ye Jianping , E-mail: yej@pbrc.edu. 2008. "Regulation of PPAR{gamma} function by TNF-{alpha}." United States.
@misc{etde_21143873,
title = {Regulation of PPAR{gamma} function by TNF-{alpha}}
author = {Ye Jianping , E-mail: yej@pbrc.edu}
abstractNote = {The nuclear receptor PPAR{gamma} is a lipid sensor that regulates lipid metabolism through gene transcription. Inhibition of PPAR{gamma} activity by TNF-{alpha} is involved in pathogenesis of insulin resistance, atherosclerosis, inflammation, and cancer cachexia. PPAR{gamma} activity is regulated by TNF-{alpha} at pre-translational and post-translational levels. Activation of serine kinases including IKK, ERK, JNK, and p38 may be involved in the TNF-regulation of PPAR{gamma}. Of the four kinases, IKK is a dominant signaling molecule in the TNF-regulation of PPAR{gamma}. IKK acts through at least two mechanisms: inhibition of PPAR{gamma} expression and activation of PPAR{gamma} corepressor. In this review article, literature is reviewed with a focus on the mechanisms of PPAR{gamma} inhibition by TNF-{alpha}.}
journal = {Biochemical and Biophysical Research Communications}
issue = {3}
volume = {374}
place = {United States}
year = {2008}
month = {Sep}
}