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The Role of Radiotherapy in the Treatment of Extrahepatic Bile Duct Carcinoma

Journal Article:

Abstract

Twenty-seven patients with unresectable extrahepatic bile duct carcinoma (n=21) or with microscopic evidence of tumor rest after aggressive surgery for extrahepatic bile duct carcinoma(n=6) between 1985 and 1990 were given radiotherapy consisting intentionally external radiotherapy and /or intraluminal therapy using Gamma-Med 12i (192-lr) high dose rate (HDR) remote control afterloading system following bile drainage procedures and Gianturco stent insertion. The objectives of this study has been to assess the feasibility and effects on survival of a combination of external radiotherapy and brachytherapy with which we hope to achieve optimal loco-regional control for patients with unresectable extrahepatic bile duct tumors. Sixteen patients were men and eleven were women, and the mean age was 58 years (34-70 ). 10MV X-ray was used for radiation therapy, with the total dose ranging from 45 Gy to 55 Gy, and intraluminal brachytherapy performed after external radiotherapy, with the dose of total 15 Gy. The minimum follow up was 12 months. Failure were predominantly local-regional, without distant failure. Median survival was 10 months; 2-year actuarial survival rates was 21%. Median survival for common hepatic duct(CHD) cancer was 9 months; for common bile duct (CBD) cancer, was 16 months. And median survival for incomplete surgery/external radiotherapy group  More>>
Authors:
Shin, Hyun Soo; Kim, Gwi Eon; Lee, Hyung Sik; Suh, Chang Ok; Loh, John Ku; Lee, Jong Tae [1] 
  1. Yonsei National University College of Medicine, Seoul (Korea, Republic of)
Publication Date:
Dec 15, 1991
Product Type:
Journal Article
Resource Relation:
Journal Name: Journal of the Korean Society for Therapeutic Radiology and Oncology; Journal Volume: 9; Journal Issue: 2; Other Information: 47 refs, 8 figs, 6 tabs
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BILIARY TRACT; BRACHYTHERAPY; CARCINOMAS; CHEMOTHERAPY; DRAINAGE; PATIENTS; SURGERY
OSTI ID:
21132021
Country of Origin:
Korea, Republic of
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1225-6765; TRN: KR0900099013144
Submitting Site:
KRN
Size:
page(s) 253-263
Announcement Date:
Mar 09, 2009

Journal Article:

Citation Formats

Shin, Hyun Soo, Kim, Gwi Eon, Lee, Hyung Sik, Suh, Chang Ok, Loh, John Ku, and Lee, Jong Tae. The Role of Radiotherapy in the Treatment of Extrahepatic Bile Duct Carcinoma. Korea, Republic of: N. p., 1991. Web.
Shin, Hyun Soo, Kim, Gwi Eon, Lee, Hyung Sik, Suh, Chang Ok, Loh, John Ku, & Lee, Jong Tae. The Role of Radiotherapy in the Treatment of Extrahepatic Bile Duct Carcinoma. Korea, Republic of.
Shin, Hyun Soo, Kim, Gwi Eon, Lee, Hyung Sik, Suh, Chang Ok, Loh, John Ku, and Lee, Jong Tae. 1991. "The Role of Radiotherapy in the Treatment of Extrahepatic Bile Duct Carcinoma." Korea, Republic of.
@misc{etde_21132021,
title = {The Role of Radiotherapy in the Treatment of Extrahepatic Bile Duct Carcinoma}
author = {Shin, Hyun Soo, Kim, Gwi Eon, Lee, Hyung Sik, Suh, Chang Ok, Loh, John Ku, and Lee, Jong Tae}
abstractNote = {Twenty-seven patients with unresectable extrahepatic bile duct carcinoma (n=21) or with microscopic evidence of tumor rest after aggressive surgery for extrahepatic bile duct carcinoma(n=6) between 1985 and 1990 were given radiotherapy consisting intentionally external radiotherapy and /or intraluminal therapy using Gamma-Med 12i (192-lr) high dose rate (HDR) remote control afterloading system following bile drainage procedures and Gianturco stent insertion. The objectives of this study has been to assess the feasibility and effects on survival of a combination of external radiotherapy and brachytherapy with which we hope to achieve optimal loco-regional control for patients with unresectable extrahepatic bile duct tumors. Sixteen patients were men and eleven were women, and the mean age was 58 years (34-70 ). 10MV X-ray was used for radiation therapy, with the total dose ranging from 45 Gy to 55 Gy, and intraluminal brachytherapy performed after external radiotherapy, with the dose of total 15 Gy. The minimum follow up was 12 months. Failure were predominantly local-regional, without distant failure. Median survival was 10 months; 2-year actuarial survival rates was 21%. Median survival for common hepatic duct(CHD) cancer was 9 months; for common bile duct (CBD) cancer, was 16 months. And median survival for incomplete surgery/external radiotherapy group and external/intraluminal radiotherapy group was 10 months; for external radiotherapy alone group, was 6 months. Use of chemotherapy and/or hyperthermia were not affected in survival. Therefore, our result is that the survival rates in the group of external/intraluminal radiotherapy were comparable with ones in the group of incomplete resection/external radiotherapy, and so we believe that the aggressive local and regional radiotherapy can improve the quality of life and the survival length.}
journal = {Journal of the Korean Society for Therapeutic Radiology and Oncology}
issue = {2}
volume = {9}
place = {Korea, Republic of}
year = {1991}
month = {Dec}
}