You need JavaScript to view this

In vivo measurement of neuronal dopamine transporter in tobacco and cannabis dependents subjects with positron tomography and [{sup 11}C]P E 2 I

Abstract

Modifications of dopamine neurotransmission are classically involved in addictive behaviors and drug reinforcement. However, to date no data are available concerning the effects of cannabis addiction on dopaminergic neurotransmission in Human. The neuronal dopamine transporter (D.A.T.) is essential for the maintenance of normal dopamine homeostasis in the brain by ensuring the re-uptake of extracellular dopamine. Therefore, observation of D.A.T. availability abnormalities in cannabis-dependents subjects could provide further evidence for the implication of dopaminergic dysfunction in this addiction. Thus, as the cannabis dependent subjects are also most of time tobacco-dependents, this work aims studying the D.A.T. availability in age-paired control, tobacco-dependent and cannabis-dependent male subjects using Positron Emission Tomography (PET). Subjects are scanned on High Resolution Research Tomograph (H.R.R.T.) for one hour after injection of a selective D.A.T. radioligand ([{sup 11}C]P.E. 2 I.) [1]. The binding potential (B.P.) is calculated in order to obtained the specific binding of [{sup 11}C]P.E. 2 I. to the D.A.T. using the simplified reference tissue model of Lammertsma (S.R.T.M.) [2] and B.P. maps were generated according to Gunn model [3]. Comparison of mean B.P. obtained in Region Of Interest and voxel to voxel comparison of B.P. maps using S.P.M.5 were performed with M.A.N.C.O.V.A. controlled for age  More>>
Authors:
Leroy, C; Ribeiro, M J; Trichard, C; Martinot, J L; [1]  CEA, Neuroimaging and Psychiatry, Unit, Hospital Dept. Frederic Joliot, I2BM, 91 - Orsay (France)]; Ribeiro, M J; Comtat, C; Dolle, F; [2]  Karila, L; Lukasiewicz, M; Reynaud, M [3] 
  1. Institut National de la Sante et de la Recherche Medicale (INSERM), U797, Research Unit, Neuroimaging and Psychiatry, IFR49, 91 - Orsay (France)
  2. Hospital Dept. Frederic Joliot, Research Medical Dept., I2BM, 91 - Orsay (France)
  3. Paul Brousse Hospital, APHP, Psychiatry and Addictology Dept., 94 - Villejuif (France)
Publication Date:
Feb 15, 2008
Product Type:
Journal Article
Resource Relation:
Journal Name: Medecine Nucleaire. Imagerie Fonctionnelle et Metabolique; Journal Volume: 32; Journal Issue: 2; Conference: 5. France - Australia nuclear medicine symposium, the role of nuclear medicine in melanoma and neuro-inflammation, Clermont-Ferrand (France), 26 Oct 2007; Other Information: 3 refs
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARBON 11; DOPAMINE; DRUGS; IN VIVO; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; TOBACCO; TRACER TECHNIQUES
OSTI ID:
21129290
Country of Origin:
France
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0928-1258; MNIMEX; TRN: FR0801237010928
Availability:
Available from doi: <http://dx.doi.org/10.1016/j.mednuc.2007.12.002>;INIS
Submitting Site:
FRN
Size:
page(s) 120
Announcement Date:
Mar 06, 2009

Citation Formats

Leroy, C, Ribeiro, M J, Trichard, C, Martinot, J L, CEA, Neuroimaging and Psychiatry, Unit, Hospital Dept. Frederic Joliot, I2BM, 91 - Orsay (France)], Ribeiro, M J, Comtat, C, Dolle, F, Karila, L, Lukasiewicz, M, and Reynaud, M. In vivo measurement of neuronal dopamine transporter in tobacco and cannabis dependents subjects with positron tomography and [{sup 11}C]P E 2 I. France: N. p., 2008. Web. doi:10.1016/J.MEDNUC.2007.12.002.
Leroy, C, Ribeiro, M J, Trichard, C, Martinot, J L, CEA, Neuroimaging and Psychiatry, Unit, Hospital Dept. Frederic Joliot, I2BM, 91 - Orsay (France)], Ribeiro, M J, Comtat, C, Dolle, F, Karila, L, Lukasiewicz, M, & Reynaud, M. In vivo measurement of neuronal dopamine transporter in tobacco and cannabis dependents subjects with positron tomography and [{sup 11}C]P E 2 I. France. doi:10.1016/J.MEDNUC.2007.12.002.
Leroy, C, Ribeiro, M J, Trichard, C, Martinot, J L, CEA, Neuroimaging and Psychiatry, Unit, Hospital Dept. Frederic Joliot, I2BM, 91 - Orsay (France)], Ribeiro, M J, Comtat, C, Dolle, F, Karila, L, Lukasiewicz, M, and Reynaud, M. 2008. "In vivo measurement of neuronal dopamine transporter in tobacco and cannabis dependents subjects with positron tomography and [{sup 11}C]P E 2 I." France. doi:10.1016/J.MEDNUC.2007.12.002. https://www.osti.gov/servlets/purl/10.1016/J.MEDNUC.2007.12.002.
@misc{etde_21129290,
title = {In vivo measurement of neuronal dopamine transporter in tobacco and cannabis dependents subjects with positron tomography and [{sup 11}C]P E 2 I}
author = {Leroy, C, Ribeiro, M J, Trichard, C, Martinot, J L, CEA, Neuroimaging and Psychiatry, Unit, Hospital Dept. Frederic Joliot, I2BM, 91 - Orsay (France)], Ribeiro, M J, Comtat, C, Dolle, F, Karila, L, Lukasiewicz, M, and Reynaud, M}
abstractNote = {Modifications of dopamine neurotransmission are classically involved in addictive behaviors and drug reinforcement. However, to date no data are available concerning the effects of cannabis addiction on dopaminergic neurotransmission in Human. The neuronal dopamine transporter (D.A.T.) is essential for the maintenance of normal dopamine homeostasis in the brain by ensuring the re-uptake of extracellular dopamine. Therefore, observation of D.A.T. availability abnormalities in cannabis-dependents subjects could provide further evidence for the implication of dopaminergic dysfunction in this addiction. Thus, as the cannabis dependent subjects are also most of time tobacco-dependents, this work aims studying the D.A.T. availability in age-paired control, tobacco-dependent and cannabis-dependent male subjects using Positron Emission Tomography (PET). Subjects are scanned on High Resolution Research Tomograph (H.R.R.T.) for one hour after injection of a selective D.A.T. radioligand ([{sup 11}C]P.E. 2 I.) [1]. The binding potential (B.P.) is calculated in order to obtained the specific binding of [{sup 11}C]P.E. 2 I. to the D.A.T. using the simplified reference tissue model of Lammertsma (S.R.T.M.) [2] and B.P. maps were generated according to Gunn model [3]. Comparison of mean B.P. obtained in Region Of Interest and voxel to voxel comparison of B.P. maps using S.P.M.5 were performed with M.A.N.C.O.V.A. controlled for age between control, tobacco-dependent and cannabis-dependent groups. Preliminary results are concordant between both approaches and shown significant decreases of the D.A.T. availability in the both groups of addicted subjects in comparison to controls at the level of dorsal and ventral striatum and the dorsal midbrain including substantia nigra and ventral tegmental area. However, no difference in D.A.T. binding between tobacco and cannabis dependents subjects was observed. These widespread modifications of D.A.T. availability in the dependents subjects might reflect a modification of dopamine neurotransmission in cannabis and/or tobacco addictions. (authors)}
doi = {10.1016/J.MEDNUC.2007.12.002}
journal = {Medecine Nucleaire. Imagerie Fonctionnelle et Metabolique}
issue = {2}
volume = {32}
place = {France}
year = {2008}
month = {Feb}
}