Abstract
The aim of this study was to investigate the regional differences between the morphologic and functional changes in the same patients with frontotemporal dementia (FTD) using statistical parametric mapping and voxel-based morphometry (VBM). Thirteen FTD patients (mean age, 64.9 years old; mean MMSE score, 17.7), 20 sex-matched Alzheimer's disease (AD) patients (mean age, 65.0 years old; mean MMSE score, 17.5), and 20 normal volunteers (mean age, 65.2 years old; mean MMSE score, 29.0) underwent both [{sup 18}F]FDG positron emission tomography and three-dimensional spoiled gradient echo MRI. Statistical parametric mapping was used to conduct a VBM analysis of the morphologic data, which were compared voxel by voxel with the results of a similar analysis of glucose metabolic data. FTD patients showed decreased grey matter volume and decreased glucose metabolism in the frontal lobe and anterior temporal lobe. In addition, there was a clear asymmetry in grey matter volume in FTD patients by the VBM analysis while the glucose metabolic data showed little asymmetry. In AD patients, glucose metabolic reduction occurred in the bilateral posterior cingulate gyri and parietal lobules while grey matter density decreased the least in the same patients. In FTD, metabolic and morphologic changes occur in the bilateral frontal
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Kanda, Tomonori;
Uemura, Takafumi;
Miyamoto, Naokazu;
Yoshikawa, Toshiki;
Kono, Atsushi K;
[1]
Ishii, Kazunari;
[1]
Hyogo Institute for Aging Brain and Cognitive Disorders, Division of Neuroimaging Research, Himeji, Hyogo (Japan)];
Mori, Etsuro;
[2]
Tohoku University Graduate School of Medicine, Behavioral Neurology and Cognitive Neuroscience, Sendai, Miyagi (Japan)]
- Hyogo Brain and Heart Center, Department of Radiology and Nuclear Medicine, Himeji, Hyogo (Japan)
- Hyogo Institute for Aging Brain and Cognitive Disorders, Division of Clinical Neurosciences, Himeji, Hyogo (Japan)
Citation Formats
Kanda, Tomonori, Uemura, Takafumi, Miyamoto, Naokazu, Yoshikawa, Toshiki, Kono, Atsushi K, Ishii, Kazunari, Hyogo Institute for Aging Brain and Cognitive Disorders, Division of Neuroimaging Research, Himeji, Hyogo (Japan)], Mori, Etsuro, and Tohoku University Graduate School of Medicine, Behavioral Neurology and Cognitive Neuroscience, Sendai, Miyagi (Japan)].
Comparison of grey matter and metabolic reductions in frontotemporal dementia using FDG-PET and voxel-based morphometric MR studies.
Germany: N. p.,
2008.
Web.
doi:10.1007/S00259-008-0871-5.
Kanda, Tomonori, Uemura, Takafumi, Miyamoto, Naokazu, Yoshikawa, Toshiki, Kono, Atsushi K, Ishii, Kazunari, Hyogo Institute for Aging Brain and Cognitive Disorders, Division of Neuroimaging Research, Himeji, Hyogo (Japan)], Mori, Etsuro, & Tohoku University Graduate School of Medicine, Behavioral Neurology and Cognitive Neuroscience, Sendai, Miyagi (Japan)].
Comparison of grey matter and metabolic reductions in frontotemporal dementia using FDG-PET and voxel-based morphometric MR studies.
Germany.
https://doi.org/10.1007/S00259-008-0871-5
Kanda, Tomonori, Uemura, Takafumi, Miyamoto, Naokazu, Yoshikawa, Toshiki, Kono, Atsushi K, Ishii, Kazunari, Hyogo Institute for Aging Brain and Cognitive Disorders, Division of Neuroimaging Research, Himeji, Hyogo (Japan)], Mori, Etsuro, and Tohoku University Graduate School of Medicine, Behavioral Neurology and Cognitive Neuroscience, Sendai, Miyagi (Japan)].
2008.
"Comparison of grey matter and metabolic reductions in frontotemporal dementia using FDG-PET and voxel-based morphometric MR studies."
Germany.
https://doi.org/10.1007/S00259-008-0871-5.
@misc{etde_21122136,
title = {Comparison of grey matter and metabolic reductions in frontotemporal dementia using FDG-PET and voxel-based morphometric MR studies}
author = {Kanda, Tomonori, Uemura, Takafumi, Miyamoto, Naokazu, Yoshikawa, Toshiki, Kono, Atsushi K, Ishii, Kazunari, Hyogo Institute for Aging Brain and Cognitive Disorders, Division of Neuroimaging Research, Himeji, Hyogo (Japan)], Mori, Etsuro, and Tohoku University Graduate School of Medicine, Behavioral Neurology and Cognitive Neuroscience, Sendai, Miyagi (Japan)]}
abstractNote = {The aim of this study was to investigate the regional differences between the morphologic and functional changes in the same patients with frontotemporal dementia (FTD) using statistical parametric mapping and voxel-based morphometry (VBM). Thirteen FTD patients (mean age, 64.9 years old; mean MMSE score, 17.7), 20 sex-matched Alzheimer's disease (AD) patients (mean age, 65.0 years old; mean MMSE score, 17.5), and 20 normal volunteers (mean age, 65.2 years old; mean MMSE score, 29.0) underwent both [{sup 18}F]FDG positron emission tomography and three-dimensional spoiled gradient echo MRI. Statistical parametric mapping was used to conduct a VBM analysis of the morphologic data, which were compared voxel by voxel with the results of a similar analysis of glucose metabolic data. FTD patients showed decreased grey matter volume and decreased glucose metabolism in the frontal lobe and anterior temporal lobe. In addition, there was a clear asymmetry in grey matter volume in FTD patients by the VBM analysis while the glucose metabolic data showed little asymmetry. In AD patients, glucose metabolic reduction occurred in the bilateral posterior cingulate gyri and parietal lobules while grey matter density decreased the least in the same patients. In FTD, metabolic and morphologic changes occur in the bilateral frontal lobe and temporal lobe with a limited asymmetry whereas there was considerable discordance in the AD group. (orig.)}
doi = {10.1007/S00259-008-0871-5}
journal = []
issue = {12}
volume = {35}
place = {Germany}
year = {2008}
month = {Dec}
}
title = {Comparison of grey matter and metabolic reductions in frontotemporal dementia using FDG-PET and voxel-based morphometric MR studies}
author = {Kanda, Tomonori, Uemura, Takafumi, Miyamoto, Naokazu, Yoshikawa, Toshiki, Kono, Atsushi K, Ishii, Kazunari, Hyogo Institute for Aging Brain and Cognitive Disorders, Division of Neuroimaging Research, Himeji, Hyogo (Japan)], Mori, Etsuro, and Tohoku University Graduate School of Medicine, Behavioral Neurology and Cognitive Neuroscience, Sendai, Miyagi (Japan)]}
abstractNote = {The aim of this study was to investigate the regional differences between the morphologic and functional changes in the same patients with frontotemporal dementia (FTD) using statistical parametric mapping and voxel-based morphometry (VBM). Thirteen FTD patients (mean age, 64.9 years old; mean MMSE score, 17.7), 20 sex-matched Alzheimer's disease (AD) patients (mean age, 65.0 years old; mean MMSE score, 17.5), and 20 normal volunteers (mean age, 65.2 years old; mean MMSE score, 29.0) underwent both [{sup 18}F]FDG positron emission tomography and three-dimensional spoiled gradient echo MRI. Statistical parametric mapping was used to conduct a VBM analysis of the morphologic data, which were compared voxel by voxel with the results of a similar analysis of glucose metabolic data. FTD patients showed decreased grey matter volume and decreased glucose metabolism in the frontal lobe and anterior temporal lobe. In addition, there was a clear asymmetry in grey matter volume in FTD patients by the VBM analysis while the glucose metabolic data showed little asymmetry. In AD patients, glucose metabolic reduction occurred in the bilateral posterior cingulate gyri and parietal lobules while grey matter density decreased the least in the same patients. In FTD, metabolic and morphologic changes occur in the bilateral frontal lobe and temporal lobe with a limited asymmetry whereas there was considerable discordance in the AD group. (orig.)}
doi = {10.1007/S00259-008-0871-5}
journal = []
issue = {12}
volume = {35}
place = {Germany}
year = {2008}
month = {Dec}
}