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Safety profile of parental ketamine and lignocaine infiltration in pediatric operations

Journal Article:

Abstract

Objective was to study the safety and benefits of parenteral ketamine and lignocaine infiltration among pediatric surgical patients with co-morbidities that would preclude the use of general anesthesia requiring endotracheal intubation/ face mask in a developing country. This prospective study was undertaken at the Leadeks Medical Centre, Benin City Edo State, Nigeria between January 2002 and December 2006. Patients requiring surgery were safely operated even in the presence of co-morbidity. A total of 416 children were recruited and they were aged 6 days to16 years (mean 12-/+ 2.04 years) with a male/ female ratio of 1:1.1. Appendectomy (33.2%), herniotomy (20.2%) and suturing of laceration (15.9%) were the most common indications for surgery. Anemia, upper respiratory tract infections, malnutrition, malaria fever, typhoid fever and retroviral infections were co-morbidities. Ambulatory surgery was carried out in 48.6% patients. Overall, only 23.3% experienced postoperative pain which was statistically significant in those that had laparotomy and appendectomy (p<0.0001) and analgesics such as paracetamol were enough to relieve the pain. Complications recorded such as postoperative vomiting, emergence reaction, wound infection, post operative fever and apnea occurring after ketamine injections were tolerated and no mortality was recorded. The satisfactory anesthesia and analgesia recorded with this combination and  More>>
Authors:
Osifo, David O; Emeagui, Kennedy N; [1]  Aghahowa, Sylvester E [2] 
  1. Dept. of Surgery, Pediatric Surgery Unit, Univ. of Benin (Nigeria)
  2. Pharmacy Dept., Univ. of Benin, Benin City (Nigeria)
Publication Date:
Jul 01, 2008
Product Type:
Journal Article
Resource Relation:
Journal Name: Saudi Medical Journal; Journal Volume: 29; Journal Issue: 1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANESTHESIA; DEVELOPING COUNTRIES; INJECTION; NIGERIA; PATIENTS; PEDIATRICS; SAFETY; SURGERY; THERAPY
OSTI ID:
21112584
Country of Origin:
Saudi Arabia
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0379-5284; TRN: SA0800309120084
Submitting Site:
INIS
Size:
page(s) 60-64
Announcement Date:
Dec 19, 2008

Journal Article:

Citation Formats

Osifo, David O, Emeagui, Kennedy N, and Aghahowa, Sylvester E. Safety profile of parental ketamine and lignocaine infiltration in pediatric operations. Saudi Arabia: N. p., 2008. Web.
Osifo, David O, Emeagui, Kennedy N, & Aghahowa, Sylvester E. Safety profile of parental ketamine and lignocaine infiltration in pediatric operations. Saudi Arabia.
Osifo, David O, Emeagui, Kennedy N, and Aghahowa, Sylvester E. 2008. "Safety profile of parental ketamine and lignocaine infiltration in pediatric operations." Saudi Arabia.
@misc{etde_21112584,
title = {Safety profile of parental ketamine and lignocaine infiltration in pediatric operations}
author = {Osifo, David O, Emeagui, Kennedy N, and Aghahowa, Sylvester E}
abstractNote = {Objective was to study the safety and benefits of parenteral ketamine and lignocaine infiltration among pediatric surgical patients with co-morbidities that would preclude the use of general anesthesia requiring endotracheal intubation/ face mask in a developing country. This prospective study was undertaken at the Leadeks Medical Centre, Benin City Edo State, Nigeria between January 2002 and December 2006. Patients requiring surgery were safely operated even in the presence of co-morbidity. A total of 416 children were recruited and they were aged 6 days to16 years (mean 12-/+ 2.04 years) with a male/ female ratio of 1:1.1. Appendectomy (33.2%), herniotomy (20.2%) and suturing of laceration (15.9%) were the most common indications for surgery. Anemia, upper respiratory tract infections, malnutrition, malaria fever, typhoid fever and retroviral infections were co-morbidities. Ambulatory surgery was carried out in 48.6% patients. Overall, only 23.3% experienced postoperative pain which was statistically significant in those that had laparotomy and appendectomy (p<0.0001) and analgesics such as paracetamol were enough to relieve the pain. Complications recorded such as postoperative vomiting, emergence reaction, wound infection, post operative fever and apnea occurring after ketamine injections were tolerated and no mortality was recorded. The satisfactory anesthesia and analgesia recorded with this combination and the low complications observed in the presence of co-morbidity showed that these agents have much to offer in a developing country. (author)}
journal = {Saudi Medical Journal}
issue = {1}
volume = {29}
place = {Saudi Arabia}
year = {2008}
month = {Jul}
}