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Selective arterial thrombolysis with urokinase

Journal Article:

Abstract

Seven patients with thrombotic occlusions of the peripheral arteries or grafts were treated with urokinase by direct intraarterial selective infusion. During the infusion, simultaneous heparin infusion was used to reduce the frequency of thrombus formation on the infusion catheter or recurrent thrombosis. In 4 patients in whom a complete thrombolysis occurred, urokinase was infused by a high-dose transthrombus bolus technique followed by continuous infusion. There other patients, in whom thrombolysis was partially accomplished and then surgical thrombectomy was performed, were treated only by continuous urokinase infusion. Small hematomas developed at the infusion catheter entry site in 2 patients, but transfusion or operation was not required. Other significant complications were not found. Our results suggest that selective arterial infusion of urokinase with a transthrombus bolus technique can accomplish a complete arterial thrombolysis without any significant complications.
Authors:
Park, Jae Hyung; Park, Kil Sun; Chung, Jin Wook; Han, Joon Koo; Kim, Sang Joon; [1]  Kim, Dae Young [2] 
  1. Seoul National University College of Medicine, Seoul (Korea, Republic of)
  2. Choong Buk University College of Medicine, Jeonju (Korea, Republic of)
Publication Date:
Jul 15, 1991
Product Type:
Journal Article
Resource Relation:
Journal Name: Journal of the Korean Radiological Society; Journal Volume: 27; Journal Issue: 4; Other Information: 13 refs, 2 figs, 1 tab
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ARTERIES; PATIENTS; PROSTHESES; SURGERY; THERAPY; THROMBOSIS; UROKINASE
OSTI ID:
21111926
Country of Origin:
Korea, Republic of
Language:
Korean
Other Identifying Numbers:
Journal ID: ISSN 1738-2637; DBSHAH; TRN: KR0803441119426
Submitting Site:
KRN
Size:
page(s) 441-446
Announcement Date:
Dec 19, 2008

Journal Article:

Citation Formats

Park, Jae Hyung, Park, Kil Sun, Chung, Jin Wook, Han, Joon Koo, Kim, Sang Joon, and Kim, Dae Young. Selective arterial thrombolysis with urokinase. Korea, Republic of: N. p., 1991. Web.
Park, Jae Hyung, Park, Kil Sun, Chung, Jin Wook, Han, Joon Koo, Kim, Sang Joon, & Kim, Dae Young. Selective arterial thrombolysis with urokinase. Korea, Republic of.
Park, Jae Hyung, Park, Kil Sun, Chung, Jin Wook, Han, Joon Koo, Kim, Sang Joon, and Kim, Dae Young. 1991. "Selective arterial thrombolysis with urokinase." Korea, Republic of.
@misc{etde_21111926,
title = {Selective arterial thrombolysis with urokinase}
author = {Park, Jae Hyung, Park, Kil Sun, Chung, Jin Wook, Han, Joon Koo, Kim, Sang Joon, and Kim, Dae Young}
abstractNote = {Seven patients with thrombotic occlusions of the peripheral arteries or grafts were treated with urokinase by direct intraarterial selective infusion. During the infusion, simultaneous heparin infusion was used to reduce the frequency of thrombus formation on the infusion catheter or recurrent thrombosis. In 4 patients in whom a complete thrombolysis occurred, urokinase was infused by a high-dose transthrombus bolus technique followed by continuous infusion. There other patients, in whom thrombolysis was partially accomplished and then surgical thrombectomy was performed, were treated only by continuous urokinase infusion. Small hematomas developed at the infusion catheter entry site in 2 patients, but transfusion or operation was not required. Other significant complications were not found. Our results suggest that selective arterial infusion of urokinase with a transthrombus bolus technique can accomplish a complete arterial thrombolysis without any significant complications.}
journal = {Journal of the Korean Radiological Society}
issue = {4}
volume = {27}
place = {Korea, Republic of}
year = {1991}
month = {Jul}
}