Abstract
A new anticancer precursor, di-peptide[p-Boc-Gly-Tyr-NH(CH{sub 2}){sub 2} NH-PO (ONH{sub 4})-O-PhI*], was synthesized and labelled with {sup 131}I using enveloped-tube technique, the labelling yield could reach 85%. Using cell coalescent method, the biological activity in vitro of the labelled compounds was evaluated, showing that the primary appetency was kept and not damaged obviously during labelling. Results on judgement of their stability, lipophilicity and toxicity demonstrated lower toxicity, higher lipophilicity and lower iodium disassociation percentage (<12% after 72 h); furthermore, a tumour-bearing animal model, was establishd successfully, on which, the biological properties of the labelled agent was studied. (authors)
Jiaheng, He;
Shubin, Jiang;
Guanquan, Wang
[1]
- China Academy of Engineering Physics, Mianyang (China). Inst. of Nuclear Physics and Chemistry
Citation Formats
Jiaheng, He, Shubin, Jiang, and Guanquan, Wang.
A new anticancer agent--{sup 131}I BGTP.
China: N. p.,
2007.
Web.
Jiaheng, He, Shubin, Jiang, & Guanquan, Wang.
A new anticancer agent--{sup 131}I BGTP.
China.
Jiaheng, He, Shubin, Jiang, and Guanquan, Wang.
2007.
"A new anticancer agent--{sup 131}I BGTP."
China.
@misc{etde_21104128,
title = {A new anticancer agent--{sup 131}I BGTP}
author = {Jiaheng, He, Shubin, Jiang, and Guanquan, Wang}
abstractNote = {A new anticancer precursor, di-peptide[p-Boc-Gly-Tyr-NH(CH{sub 2}){sub 2} NH-PO (ONH{sub 4})-O-PhI*], was synthesized and labelled with {sup 131}I using enveloped-tube technique, the labelling yield could reach 85%. Using cell coalescent method, the biological activity in vitro of the labelled compounds was evaluated, showing that the primary appetency was kept and not damaged obviously during labelling. Results on judgement of their stability, lipophilicity and toxicity demonstrated lower toxicity, higher lipophilicity and lower iodium disassociation percentage (<12% after 72 h); furthermore, a tumour-bearing animal model, was establishd successfully, on which, the biological properties of the labelled agent was studied. (authors)}
place = {China}
year = {2007}
month = {Dec}
}
title = {A new anticancer agent--{sup 131}I BGTP}
author = {Jiaheng, He, Shubin, Jiang, and Guanquan, Wang}
abstractNote = {A new anticancer precursor, di-peptide[p-Boc-Gly-Tyr-NH(CH{sub 2}){sub 2} NH-PO (ONH{sub 4})-O-PhI*], was synthesized and labelled with {sup 131}I using enveloped-tube technique, the labelling yield could reach 85%. Using cell coalescent method, the biological activity in vitro of the labelled compounds was evaluated, showing that the primary appetency was kept and not damaged obviously during labelling. Results on judgement of their stability, lipophilicity and toxicity demonstrated lower toxicity, higher lipophilicity and lower iodium disassociation percentage (<12% after 72 h); furthermore, a tumour-bearing animal model, was establishd successfully, on which, the biological properties of the labelled agent was studied. (authors)}
place = {China}
year = {2007}
month = {Dec}
}