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Theoretical study of radioprotective agents DMSO, As{sub 2}O{sub 3} as differentiation-inducting agent and apoptotic agent for tumor cells

Abstract

Objective: To study the radioprotective agents DMSO, As{sub 2}O{sub 3} and their electronic structures, spectral and quantum mechanism as differentiation-inducing agent and apoptotic agent for tumor cells. Methods: To study the radioprotective agents DMSO, As{sub 2}O{sub 3} and their electronic structures, spectral and quantum mechanism as differentiation-inducing agent and apoptotic agent for tumor cells by the quantumbiological methods:ab initio and Density Functional Theory(DFT). Results: A hypothesis was produced of moderate oxidative stress of free radicals with bi-directional action selectively inducing the differentiation and apoptosis of cells. And it was tested by quantum results by way of the deputies DMSO and As{sub 2}O{sub 3}. In the meantime, the microstructural data of free radicals, including geometrical structure, electronic structure, spectral characteristics, frontier orbital,population analysis, spin analysis, ere., was studied. The free radicals were produced by exchanging electrons bidirections from DMSO and As{sub 2}O{sub 3}. A possible quantum mechanism on selectively inducing the differentiation and apoptosis of tumor cells was investigated. (authors)
Authors:
Huabin, Sun; Guangpeng, Ma [1] 
  1. Center for Disease Prevention and Control, Jinan Military Area, Jinan (China)
Publication Date:
Mar 15, 2007
Product Type:
Journal Article
Resource Relation:
Journal Name: Chinese Journal of Radiological Health; Journal Volume: 16; Journal Issue: 1; Other Information: 7 refs
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; APOPTOSIS; ARSENIC OXIDES; CELL DIFFERENTIATION; DENSITY FUNCTIONAL METHOD; DMSO; ELECTRON EXCHANGE; ELECTRONIC STRUCTURE; MICROSTRUCTURE; MUTAGENESIS; OXIDATION; RADICALS; RADIOPROTECTIVE SUBSTANCES; SPIN; TUMOR CELLS
OSTI ID:
21100943
Country of Origin:
China
Language:
Chinese
Other Identifying Numbers:
Journal ID: ISSN 1004-714X; TRN: CN0802713111038
Submitting Site:
INIS
Size:
page(s) 12-14
Announcement Date:
Dec 15, 2008

Citation Formats

Huabin, Sun, and Guangpeng, Ma. Theoretical study of radioprotective agents DMSO, As{sub 2}O{sub 3} as differentiation-inducting agent and apoptotic agent for tumor cells. China: N. p., 2007. Web.
Huabin, Sun, & Guangpeng, Ma. Theoretical study of radioprotective agents DMSO, As{sub 2}O{sub 3} as differentiation-inducting agent and apoptotic agent for tumor cells. China.
Huabin, Sun, and Guangpeng, Ma. 2007. "Theoretical study of radioprotective agents DMSO, As{sub 2}O{sub 3} as differentiation-inducting agent and apoptotic agent for tumor cells." China.
@misc{etde_21100943,
title = {Theoretical study of radioprotective agents DMSO, As{sub 2}O{sub 3} as differentiation-inducting agent and apoptotic agent for tumor cells}
author = {Huabin, Sun, and Guangpeng, Ma}
abstractNote = {Objective: To study the radioprotective agents DMSO, As{sub 2}O{sub 3} and their electronic structures, spectral and quantum mechanism as differentiation-inducing agent and apoptotic agent for tumor cells. Methods: To study the radioprotective agents DMSO, As{sub 2}O{sub 3} and their electronic structures, spectral and quantum mechanism as differentiation-inducing agent and apoptotic agent for tumor cells by the quantumbiological methods:ab initio and Density Functional Theory(DFT). Results: A hypothesis was produced of moderate oxidative stress of free radicals with bi-directional action selectively inducing the differentiation and apoptosis of cells. And it was tested by quantum results by way of the deputies DMSO and As{sub 2}O{sub 3}. In the meantime, the microstructural data of free radicals, including geometrical structure, electronic structure, spectral characteristics, frontier orbital,population analysis, spin analysis, ere., was studied. The free radicals were produced by exchanging electrons bidirections from DMSO and As{sub 2}O{sub 3}. A possible quantum mechanism on selectively inducing the differentiation and apoptosis of tumor cells was investigated. (authors)}
journal = []
issue = {1}
volume = {16}
place = {China}
year = {2007}
month = {Mar}
}