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Application of compartmental metabolic models for determination of retention and excretion functions; Aplicacao de modelos metabolicos para a determinacao de funcoes de excrecao e retencao

Abstract

After an intake of radioactive material, its behaviour in the human body can be described by mathematical models, where organs, tissues or regions of the body are treated as a chain of linked compartments. The mathematical approach for such metabolic models is usually done through a system of differential equations of first order with constant coefficients. The solutions of this system of equations associates the radionuclide intake, with the fraction excreted or retained in the organ of interest. A computer program - called INCORP and for running in PC compatible microcomputers - was developed in order to find the solutions of such system of equations, using an analytical method based on expansion of series of exponential matrices. The metabolic model presented in the ICRP-30 publication was simulated using the INCORP program, in order to find the respective retention and excretion curves for selected radionuclides. (author)
Publication Date:
Jul 01, 1994
Product Type:
Thesis/Dissertation
Report Number:
INIS-BR-3412
Resource Relation:
Other Information: TH: Tese (M.Sc.)
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BODY; DIFFERENTIAL EQUATIONS; DOSE LIMITS; DOSIMETRY; EXCRETION; ICRP; INTAKE; MATHEMATICAL MODELS; MICROCOMPUTERS; PERSONNEL MONITORING; PROGRAMMING; RADIATION DOSES; RADIONUCLIDE KINETICS; SIMULATION
OSTI ID:
21100397
Research Organizations:
Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil)
Country of Origin:
Brazil
Language:
Portuguese
Other Identifying Numbers:
TRN: BR94A2250110491
Availability:
Available from INIS in electronic form
Submitting Site:
BRN
Size:
99 pages
Announcement Date:
Dec 05, 2008

Citation Formats

Rodrigues, Junior, O. Application of compartmental metabolic models for determination of retention and excretion functions; Aplicacao de modelos metabolicos para a determinacao de funcoes de excrecao e retencao. Brazil: N. p., 1994. Web.
Rodrigues, Junior, O. Application of compartmental metabolic models for determination of retention and excretion functions; Aplicacao de modelos metabolicos para a determinacao de funcoes de excrecao e retencao. Brazil.
Rodrigues, Junior, O. 1994. "Application of compartmental metabolic models for determination of retention and excretion functions; Aplicacao de modelos metabolicos para a determinacao de funcoes de excrecao e retencao." Brazil.
@misc{etde_21100397,
title = {Application of compartmental metabolic models for determination of retention and excretion functions; Aplicacao de modelos metabolicos para a determinacao de funcoes de excrecao e retencao}
author = {Rodrigues, Junior, O}
abstractNote = {After an intake of radioactive material, its behaviour in the human body can be described by mathematical models, where organs, tissues or regions of the body are treated as a chain of linked compartments. The mathematical approach for such metabolic models is usually done through a system of differential equations of first order with constant coefficients. The solutions of this system of equations associates the radionuclide intake, with the fraction excreted or retained in the organ of interest. A computer program - called INCORP and for running in PC compatible microcomputers - was developed in order to find the solutions of such system of equations, using an analytical method based on expansion of series of exponential matrices. The metabolic model presented in the ICRP-30 publication was simulated using the INCORP program, in order to find the respective retention and excretion curves for selected radionuclides. (author)}
place = {Brazil}
year = {1994}
month = {Jul}
}