Abstract
The effect of radiation on the liver should be of unusual interest in as much as there are two highly specialized kinds of epithelium besides an important endothelial system and vascular and fibrous elements to compare. But there are several difficulties in the way of a knowledge of the sensitivity and reaction of the liver to radiation. Perhaps the most important is the regenerative ability of the liver cells. It has been assumed that the liver as an organ is relatively resistant to radiation injury. Yet there are reports of necorsis of the liver in man resulting from doses of radiation which have not caused a skin reaction or any demonstrable effect on the stomach. The author made an experiment to elucidate more clearly the changes in serum enzymes and histopathology of rat's liver following irradiation to the liver with a single dose of 2,000 rads. The results obtained are as follows: 1. Serum SGOT activities were significantly elevated, 1 and 2 weeks after irradiation, and normalized after 4 weeks. 2. Serum SGPT activities were significantly elevated 2 weeks after irradiation, and normalized after 4 weeks. 3. Alakline phosphatase activity were significantly elevated 1, 2 and 4 weeks after irradiation,
More>>
Kang, Ik Won;
Park, Charn Il;
Kim, Chu Wan
[1]
- College of Medicine, Seoul National University, Seoul (Korea, Republic of)
Citation Formats
Kang, Ik Won, Park, Charn Il, and Kim, Chu Wan.
An experimental study on radiation hepatitis.
Korea, Republic of: N. p.,
1981.
Web.
Kang, Ik Won, Park, Charn Il, & Kim, Chu Wan.
An experimental study on radiation hepatitis.
Korea, Republic of.
Kang, Ik Won, Park, Charn Il, and Kim, Chu Wan.
1981.
"An experimental study on radiation hepatitis."
Korea, Republic of.
@misc{etde_21071661,
title = {An experimental study on radiation hepatitis}
author = {Kang, Ik Won, Park, Charn Il, and Kim, Chu Wan}
abstractNote = {The effect of radiation on the liver should be of unusual interest in as much as there are two highly specialized kinds of epithelium besides an important endothelial system and vascular and fibrous elements to compare. But there are several difficulties in the way of a knowledge of the sensitivity and reaction of the liver to radiation. Perhaps the most important is the regenerative ability of the liver cells. It has been assumed that the liver as an organ is relatively resistant to radiation injury. Yet there are reports of necorsis of the liver in man resulting from doses of radiation which have not caused a skin reaction or any demonstrable effect on the stomach. The author made an experiment to elucidate more clearly the changes in serum enzymes and histopathology of rat's liver following irradiation to the liver with a single dose of 2,000 rads. The results obtained are as follows: 1. Serum SGOT activities were significantly elevated, 1 and 2 weeks after irradiation, and normalized after 4 weeks. 2. Serum SGPT activities were significantly elevated 2 weeks after irradiation, and normalized after 4 weeks. 3. Alakline phosphatase activity were significantly elevated 1, 2 and 4 weeks after irradiation, and normalized after 8 weeks. 4. Histopathologic changes were focal necrosis, inflammatory cell infiltrations, loss of intracytoplasmic glycogen particles, and vacuolar degenerations of hepatocytes. It appeared marked 2 weeks after irradiation, restored after 4 weeks, and normalized after 8 weeks.}
journal = []
issue = {2}
volume = {17}
place = {Korea, Republic of}
year = {1981}
month = {Sep}
}
title = {An experimental study on radiation hepatitis}
author = {Kang, Ik Won, Park, Charn Il, and Kim, Chu Wan}
abstractNote = {The effect of radiation on the liver should be of unusual interest in as much as there are two highly specialized kinds of epithelium besides an important endothelial system and vascular and fibrous elements to compare. But there are several difficulties in the way of a knowledge of the sensitivity and reaction of the liver to radiation. Perhaps the most important is the regenerative ability of the liver cells. It has been assumed that the liver as an organ is relatively resistant to radiation injury. Yet there are reports of necorsis of the liver in man resulting from doses of radiation which have not caused a skin reaction or any demonstrable effect on the stomach. The author made an experiment to elucidate more clearly the changes in serum enzymes and histopathology of rat's liver following irradiation to the liver with a single dose of 2,000 rads. The results obtained are as follows: 1. Serum SGOT activities were significantly elevated, 1 and 2 weeks after irradiation, and normalized after 4 weeks. 2. Serum SGPT activities were significantly elevated 2 weeks after irradiation, and normalized after 4 weeks. 3. Alakline phosphatase activity were significantly elevated 1, 2 and 4 weeks after irradiation, and normalized after 8 weeks. 4. Histopathologic changes were focal necrosis, inflammatory cell infiltrations, loss of intracytoplasmic glycogen particles, and vacuolar degenerations of hepatocytes. It appeared marked 2 weeks after irradiation, restored after 4 weeks, and normalized after 8 weeks.}
journal = []
issue = {2}
volume = {17}
place = {Korea, Republic of}
year = {1981}
month = {Sep}
}