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The influences of silent cerebral infarction and hypertension on brain atrophy in normal adults

Abstract

We studied the influences of silent brain infarction (SBI) and hypertension on brain atrophy and its longitudinal progression in healthy adults. MRI scans were performed on 109 neurologically normal adults (mean age, 58.6{+-}5.8 years), with follow-up at an average of 4.9 years later. Patient histories of hypertension, smoking habits, and alcohol consumption were examined. We evaluated brain atrophy using the brain atrophy index (BAI; the ratio of the brain area to the intracranial area) and the ventricular atrophy index (VAI; the ratio of the ventricular area to the brain area) on MRI T1-weighted images at the levels of the basal ganglia and lateral ventricle in horizontal sections. There were no differences in age, sex, dyslipidemia, body mass index (BMI), smoking habit, and alcohol consumption between the normal group and the SBI or hypertension group. The BAI was significantly lower at entry for the SBI (+) group than for the SBI (-) group at both the basal ganglia and lateral ventricle levels (basal ganglia level, p=0.02; and lateral ventricle level, p=0.05). Moreover, the VAI was significantly higher at entry for the SBI (+) group than for the SBI (-) group at the lateral ventricle level (p=0.03). Furthermore, the BAI was significantly  More>>
Authors:
Zhefeng, Quan; Bokura, Hirokazu; Iijima, Kenichi; Oguro, Hiroaki; Yamaguchi, Shuhei [1] 
  1. Shimane Univ., Faculty of Medicine, Izumo, Shimane (Japan)
Publication Date:
Mar 15, 2008
Product Type:
Journal Article
Resource Relation:
Journal Name: Nippon Ronen Igakkai Zasshi; Journal Volume: 45; Journal Issue: 2
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ADULTS; ATROPHY; CEREBRAL CORTEX; HYPERTENSION; INDEXES; NMR IMAGING; PATIENTS; SIGNALS; SPIN-LATTICE RELAXATION; SPIN-SPIN RELAXATION
OSTI ID:
21068932
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: ISSN 0300-9173; NIRZAL; TRN: JP0803103083123
Submitting Site:
INIS
Size:
page(s) 175-181
Announcement Date:
Oct 02, 2008

Citation Formats

Zhefeng, Quan, Bokura, Hirokazu, Iijima, Kenichi, Oguro, Hiroaki, and Yamaguchi, Shuhei. The influences of silent cerebral infarction and hypertension on brain atrophy in normal adults. Japan: N. p., 2008. Web. doi:10.3143/geriatrics.45.175.
Zhefeng, Quan, Bokura, Hirokazu, Iijima, Kenichi, Oguro, Hiroaki, & Yamaguchi, Shuhei. The influences of silent cerebral infarction and hypertension on brain atrophy in normal adults. Japan. https://doi.org/10.3143/geriatrics.45.175
Zhefeng, Quan, Bokura, Hirokazu, Iijima, Kenichi, Oguro, Hiroaki, and Yamaguchi, Shuhei. 2008. "The influences of silent cerebral infarction and hypertension on brain atrophy in normal adults." Japan. https://doi.org/10.3143/geriatrics.45.175.
@misc{etde_21068932,
title = {The influences of silent cerebral infarction and hypertension on brain atrophy in normal adults}
author = {Zhefeng, Quan, Bokura, Hirokazu, Iijima, Kenichi, Oguro, Hiroaki, and Yamaguchi, Shuhei}
abstractNote = {We studied the influences of silent brain infarction (SBI) and hypertension on brain atrophy and its longitudinal progression in healthy adults. MRI scans were performed on 109 neurologically normal adults (mean age, 58.6{+-}5.8 years), with follow-up at an average of 4.9 years later. Patient histories of hypertension, smoking habits, and alcohol consumption were examined. We evaluated brain atrophy using the brain atrophy index (BAI; the ratio of the brain area to the intracranial area) and the ventricular atrophy index (VAI; the ratio of the ventricular area to the brain area) on MRI T1-weighted images at the levels of the basal ganglia and lateral ventricle in horizontal sections. There were no differences in age, sex, dyslipidemia, body mass index (BMI), smoking habit, and alcohol consumption between the normal group and the SBI or hypertension group. The BAI was significantly lower at entry for the SBI (+) group than for the SBI (-) group at both the basal ganglia and lateral ventricle levels (basal ganglia level, p=0.02; and lateral ventricle level, p=0.05). Moreover, the VAI was significantly higher at entry for the SBI (+) group than for the SBI (-) group at the lateral ventricle level (p=0.03). Furthermore, the BAI was significantly lower at entry for the hypertensive group than for the non-hypertensive group at the basal ganglia level (p=0.007). There were no significant differences in the annual variations of the BAI and VAI between the normal group and the SBI (+) or hypertensive group. The present results suggest that the SBI and hypertension are accelerating factors for brain atrophy and ventricular dilatation. (author)}
doi = {10.3143/geriatrics.45.175}
journal = []
issue = {2}
volume = {45}
place = {Japan}
year = {2008}
month = {Mar}
}