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Sonic hedgehog promotes stem-cell potential of Mueller glia in the mammalian retina

Abstract

Mueller glia have been demonstrated to display stem-cell properties after retinal damage. Here, we report this potential can be regulated by Sonic hedgehog (Shh) signaling. Shh can stimulate proliferation of Mueller glia through its receptor and target gene expressed on them, furthermore, Shh-treated Mueller glia are induced to dedifferentiate by expressing progenitor-specific markers, and then adopt cell fate of rod photoreceptor. Inhibition of signaling by cyclopamine inhibits proliferation and dedifferentiation. Intraocular injection of Shh promotes Mueller glia activation in the photoreceptor-damaged retina, Shh also enhances neurogenic potential by producing more rhodopsin-positive photoreceptors from Mueller glia-derived cells. Together, these results provide evidences that Mueller glia act as potential stem cells in mammalian retina, Shh may have therapeutic effects on these cells for promoting the regeneration of retinal neurons.
Authors:
Jin, Wan; Hua, Zheng; Honglei, Xiao; Zhenjue, She; [1]  Zhou Guomin , E-mail: gmzhou185@yahoo.com.cn [1] 
  1. Department of Anatomy, Histology and Embryology, Shanghai Medical School, Fudan University, 200032 Shanghai (China)
Publication Date:
Nov 16, 2007
Product Type:
Journal Article
Resource Relation:
Journal Name: Biochemical and Biophysical Research Communications; Journal Volume: 363; Journal Issue: 2; Other Information: DOI: 10.1016/j.bbrc.2007.08.178; PII: S0006-291X(07)01903-1; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Subject:
60 APPLIED LIFE SCIENCES; DAMAGE; GENE REGULATION; GENES; NERVE CELLS; RECEPTORS; REGENERATION; RETINA; RHODOPSIN; STEM CELLS
OSTI ID:
21032975
Country of Origin:
United States
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0006-291X; BBRCA9; TRN: US08R0163053182
Availability:
Available from http://dx.doi.org/10.1016/j.bbrc.2007.08.178;INIS
Submitting Site:
INIS
Size:
page(s) 347-354
Announcement Date:
Jun 20, 2008

Citation Formats

Jin, Wan, Hua, Zheng, Honglei, Xiao, Zhenjue, She, and Zhou Guomin , E-mail: gmzhou185@yahoo.com.cn. Sonic hedgehog promotes stem-cell potential of Mueller glia in the mammalian retina. United States: N. p., 2007. Web. doi:10.1016/j.bbrc.2007.08.178.
Jin, Wan, Hua, Zheng, Honglei, Xiao, Zhenjue, She, & Zhou Guomin , E-mail: gmzhou185@yahoo.com.cn. Sonic hedgehog promotes stem-cell potential of Mueller glia in the mammalian retina. United States. doi:10.1016/j.bbrc.2007.08.178.
Jin, Wan, Hua, Zheng, Honglei, Xiao, Zhenjue, She, and Zhou Guomin , E-mail: gmzhou185@yahoo.com.cn. 2007. "Sonic hedgehog promotes stem-cell potential of Mueller glia in the mammalian retina." United States. doi:10.1016/j.bbrc.2007.08.178. https://www.osti.gov/servlets/purl/10.1016/j.bbrc.2007.08.178.
@misc{etde_21032975,
title = {Sonic hedgehog promotes stem-cell potential of Mueller glia in the mammalian retina}
author = {Jin, Wan, Hua, Zheng, Honglei, Xiao, Zhenjue, She, and Zhou Guomin , E-mail: gmzhou185@yahoo.com.cn}
abstractNote = {Mueller glia have been demonstrated to display stem-cell properties after retinal damage. Here, we report this potential can be regulated by Sonic hedgehog (Shh) signaling. Shh can stimulate proliferation of Mueller glia through its receptor and target gene expressed on them, furthermore, Shh-treated Mueller glia are induced to dedifferentiate by expressing progenitor-specific markers, and then adopt cell fate of rod photoreceptor. Inhibition of signaling by cyclopamine inhibits proliferation and dedifferentiation. Intraocular injection of Shh promotes Mueller glia activation in the photoreceptor-damaged retina, Shh also enhances neurogenic potential by producing more rhodopsin-positive photoreceptors from Mueller glia-derived cells. Together, these results provide evidences that Mueller glia act as potential stem cells in mammalian retina, Shh may have therapeutic effects on these cells for promoting the regeneration of retinal neurons.}
doi = {10.1016/j.bbrc.2007.08.178}
journal = {Biochemical and Biophysical Research Communications}
issue = {2}
volume = {363}
place = {United States}
year = {2007}
month = {Nov}
}