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Differential radioprotection and free radical scavenging activity of Caesalpinia digyna extracts and the active constituent

Abstract

Differential free radical activity of the fractionated extracts (F1: methanolic fraction, F2: acetone soluble fraction and F3: acetone insoluble fraction) of a medicinal plant Caesalpinia digyna, has been studied employing DPPH, superoxide radical and in vitro radioprotecting activity by following their effect on radiation induced protein carbonylation and DNA damage in pBR322. The activity for these fractions is in the order of F1>F2>F3. HPLC analysis indicated that all fractions contain high amount of bergenin, a polyhydroxy isocoumarin derivative and the fractions are more active than isolated bergenin. (author)
Authors:
Singh, Umang; Kunwar, A; Barik, A; Priyadarsini, K I; [1]  Mula, S; [2]  Srinivasan, R [3] 
  1. Radiation and Photochemistry Div., Bhabha Atomic Research Centre, Mumbai (India)
  2. Bio-Organic Div., Bhabha Atomic Research Centre, Mumbai (India)
  3. JSS College of Pharmacy, Ootacamund (India)
Publication Date:
Jan 15, 2008
Product Type:
Conference
Resource Relation:
Conference: TSRP-2008: 9. Trombay symposium on radiation and photochemistry, Pune (India), 7-11 Jan 2008; Other Information: 1 ref; Related Information: In: Trombay symposium on radiation and photochemistry: proceedings, invited talks and posters, 454 pages.
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; ABSORPTION SPECTRA; ACETONE; COUMARIN; CYTOCHROMES; DPPH; FRACTIONATION; MEDICINAL PLANTS; METHANOL; OXIDASES; RADIATION DOSES; SUPEROXIDE RADICALS; XANTHINES
OSTI ID:
21015053
Research Organizations:
Board of Research in Nuclear Sciences, Dept. of Atomic Energy, Mumbai (India); Indian Society for Radiation and Photochemical Sciences, Mumbai (India)
Country of Origin:
India
Language:
English
Other Identifying Numbers:
Other: ISBN 81-88513-25-3; TRN: IN0800775037268
Submitting Site:
INIS
Size:
page(s) 383-384
Announcement Date:
May 29, 2008

Citation Formats

Singh, Umang, Kunwar, A, Barik, A, Priyadarsini, K I, Mula, S, and Srinivasan, R. Differential radioprotection and free radical scavenging activity of Caesalpinia digyna extracts and the active constituent. India: N. p., 2008. Web.
Singh, Umang, Kunwar, A, Barik, A, Priyadarsini, K I, Mula, S, & Srinivasan, R. Differential radioprotection and free radical scavenging activity of Caesalpinia digyna extracts and the active constituent. India.
Singh, Umang, Kunwar, A, Barik, A, Priyadarsini, K I, Mula, S, and Srinivasan, R. 2008. "Differential radioprotection and free radical scavenging activity of Caesalpinia digyna extracts and the active constituent." India.
@misc{etde_21015053,
title = {Differential radioprotection and free radical scavenging activity of Caesalpinia digyna extracts and the active constituent}
author = {Singh, Umang, Kunwar, A, Barik, A, Priyadarsini, K I, Mula, S, and Srinivasan, R}
abstractNote = {Differential free radical activity of the fractionated extracts (F1: methanolic fraction, F2: acetone soluble fraction and F3: acetone insoluble fraction) of a medicinal plant Caesalpinia digyna, has been studied employing DPPH, superoxide radical and in vitro radioprotecting activity by following their effect on radiation induced protein carbonylation and DNA damage in pBR322. The activity for these fractions is in the order of F1>F2>F3. HPLC analysis indicated that all fractions contain high amount of bergenin, a polyhydroxy isocoumarin derivative and the fractions are more active than isolated bergenin. (author)}
place = {India}
year = {2008}
month = {Jan}
}