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Effect of the methyl gallate on the damage produced by radiation in leucocytes of peripheral blood of In vivo mouse; Efecto del metil galato sobre el dano producido por radiacion en leucocitos de sangre periferica de raton In vivo

Abstract

The ionizing radiation produces a great variety of lesions in the deoxyribonucleic acid (DNA) through the formation of free radicals (RL), reason why the study about those made up with possible radioprotective property has been increased. The methyl gallate (MeG) it is an antioxidant derived of plants with capacity to capture RL. The objective of the present work was to determine the effect of the methyl gallate on the damage in the DNA taken place by gamma radiation in leukocytes of peripheral blood of in vivo mouse. The experimental design consisted of 4 groups of mice: It has a witness of the solvent group, dimethylsulfoxide (DMSO), in which was administer by intraperitoneal via 0.4 mL of a solution 1:8 of DMSO: H{sub 2}O; a second group, denominated MeG witness, it was administered intraperitoneally with a dose of 0.1 {mu} moles/g of weight. Another group was used as radiation witness, reason why it was only treated with 1 Gray (Gy) of gamma radiation coming from a cobalt 60 source. At last, the group denominated problem it was administered with 0.1 {mu} moles of MeG/g of corporal weight 30 previous minutes to the irradiation with 1 Gy. In the comparison of the  More>>
Authors:
Zarco M, A [1] 
  1. ININ, 52750 La Marquesa, Estado de Mexico (Mexico)
Publication Date:
Jul 01, 2007
Product Type:
Thesis/Dissertation
Report Number:
INIS-MX-2517
Resource Relation:
Other Information: TH: Thesis (Pharmacologist Biologist Chemist)
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; DIAGRAMS; DNA; DOSIMETRY; ELECTROPHORESIS; ESTERS; EXPERIMENTAL DATA; GALLIC ACID; GAMMA RADIATION; IMAGES; IN VITRO; IN VIVO; IONIZING RADIATIONS; LEUKOCYTES; LITHIUM FLUORIDES; MICE; PHENOLS; PLANTS; RADIATION DOSES; RADICALS; RADIOPROTECTIVE SUBSTANCES; SAMPLING; STATISTICS; THERMOLUMINESCENT DOSEMETERS; TIME DEPENDENCE
OSTI ID:
21003837
Research Organizations:
UAEM, Facultad de Quimica, 50000 Toluca, Estado de Mexico (Mexico)
Country of Origin:
Mexico
Language:
Spanish
Other Identifying Numbers:
TRN: MX0800210027965
Availability:
Available from INIS in electronic form
Submitting Site:
MXN
Size:
91 pages
Announcement Date:
Apr 19, 2008

Citation Formats

Zarco M, A. Effect of the methyl gallate on the damage produced by radiation in leucocytes of peripheral blood of In vivo mouse; Efecto del metil galato sobre el dano producido por radiacion en leucocitos de sangre periferica de raton In vivo. Mexico: N. p., 2007. Web.
Zarco M, A. Effect of the methyl gallate on the damage produced by radiation in leucocytes of peripheral blood of In vivo mouse; Efecto del metil galato sobre el dano producido por radiacion en leucocitos de sangre periferica de raton In vivo. Mexico.
Zarco M, A. 2007. "Effect of the methyl gallate on the damage produced by radiation in leucocytes of peripheral blood of In vivo mouse; Efecto del metil galato sobre el dano producido por radiacion en leucocitos de sangre periferica de raton In vivo." Mexico.
@misc{etde_21003837,
title = {Effect of the methyl gallate on the damage produced by radiation in leucocytes of peripheral blood of In vivo mouse; Efecto del metil galato sobre el dano producido por radiacion en leucocitos de sangre periferica de raton In vivo}
author = {Zarco M, A}
abstractNote = {The ionizing radiation produces a great variety of lesions in the deoxyribonucleic acid (DNA) through the formation of free radicals (RL), reason why the study about those made up with possible radioprotective property has been increased. The methyl gallate (MeG) it is an antioxidant derived of plants with capacity to capture RL. The objective of the present work was to determine the effect of the methyl gallate on the damage in the DNA taken place by gamma radiation in leukocytes of peripheral blood of in vivo mouse. The experimental design consisted of 4 groups of mice: It has a witness of the solvent group, dimethylsulfoxide (DMSO), in which was administer by intraperitoneal via 0.4 mL of a solution 1:8 of DMSO: H{sub 2}O; a second group, denominated MeG witness, it was administered intraperitoneally with a dose of 0.1 {mu} moles/g of weight. Another group was used as radiation witness, reason why it was only treated with 1 Gray (Gy) of gamma radiation coming from a cobalt 60 source. At last, the group denominated problem it was administered with 0.1 {mu} moles of MeG/g of corporal weight 30 previous minutes to the irradiation with 1 Gy. In the comparison of the damage and repair curves obtained with the unicellular in gel electrophoresis technique among the irradiated groups, it was determined that there is one significant reduction of 15% in the DNA damage observed to the two minutes postradiation in the problem group with respect to the radiation witness. It was concluded that this decrease is due to the antioxidant effect of the methyl gallate and that therefore this compound has possibilities to act as radioprotector. (Author)}
place = {Mexico}
year = {2007}
month = {Jul}
}