Abstract
The P-53 protein holds an important contribution in the control of the cell cycle as well as the apoptosis control. But in numerous cancers the P-53 protein functionality is blocked by mutations or by its gene obliteration. The distribution of cells in the cell cycle as well as the apoptosis induction have been studied after exposure to 5-Fluorouracils (5-F.U.) or ionizing radiations. The two types of stress can induce dependent P-53 apoptosis after 5-F.U. exposure and independent P-53 apoptosis after ionizing radiation exposure. The P-53 protein is not the only one to have an important part in the cell cycle and apoptosis control, the transcription factor is important as well as the cells sensitivity to a stress such ionizing radiation. This could open new approaches of increasing the biological effects of ionizing radiations. (N.C.)
Citation Formats
Didelot, C.
Cell cycle break and apoptosis induction for the HPV-18 positive human head and neck carcinomas lines, after exposure to 5-fluorouracils and ionizing radiations:NF-kB implication in the radiosensitivity and spontaneous apoptosis; Arrets du cycle cellulaire et induction d'apoptose pour les lignees de carcinome humain de la tete et du cou HPV-18 positives, apres exposition au 5-fluorouracile et aux radiations ionisantes: implication de NF-kB dans la radiosensibilite et l'apoptose spontanee.
France: N. p.,
2002.
Web.
Didelot, C.
Cell cycle break and apoptosis induction for the HPV-18 positive human head and neck carcinomas lines, after exposure to 5-fluorouracils and ionizing radiations:NF-kB implication in the radiosensitivity and spontaneous apoptosis; Arrets du cycle cellulaire et induction d'apoptose pour les lignees de carcinome humain de la tete et du cou HPV-18 positives, apres exposition au 5-fluorouracile et aux radiations ionisantes: implication de NF-kB dans la radiosensibilite et l'apoptose spontanee.
France.
Didelot, C.
2002.
"Cell cycle break and apoptosis induction for the HPV-18 positive human head and neck carcinomas lines, after exposure to 5-fluorouracils and ionizing radiations:NF-kB implication in the radiosensitivity and spontaneous apoptosis; Arrets du cycle cellulaire et induction d'apoptose pour les lignees de carcinome humain de la tete et du cou HPV-18 positives, apres exposition au 5-fluorouracile et aux radiations ionisantes: implication de NF-kB dans la radiosensibilite et l'apoptose spontanee."
France.
@misc{etde_20997199,
title = {Cell cycle break and apoptosis induction for the HPV-18 positive human head and neck carcinomas lines, after exposure to 5-fluorouracils and ionizing radiations:NF-kB implication in the radiosensitivity and spontaneous apoptosis; Arrets du cycle cellulaire et induction d'apoptose pour les lignees de carcinome humain de la tete et du cou HPV-18 positives, apres exposition au 5-fluorouracile et aux radiations ionisantes: implication de NF-kB dans la radiosensibilite et l'apoptose spontanee}
author = {Didelot, C}
abstractNote = {The P-53 protein holds an important contribution in the control of the cell cycle as well as the apoptosis control. But in numerous cancers the P-53 protein functionality is blocked by mutations or by its gene obliteration. The distribution of cells in the cell cycle as well as the apoptosis induction have been studied after exposure to 5-Fluorouracils (5-F.U.) or ionizing radiations. The two types of stress can induce dependent P-53 apoptosis after 5-F.U. exposure and independent P-53 apoptosis after ionizing radiation exposure. The P-53 protein is not the only one to have an important part in the cell cycle and apoptosis control, the transcription factor is important as well as the cells sensitivity to a stress such ionizing radiation. This could open new approaches of increasing the biological effects of ionizing radiations. (N.C.)}
place = {France}
year = {2002}
month = {Apr}
}
title = {Cell cycle break and apoptosis induction for the HPV-18 positive human head and neck carcinomas lines, after exposure to 5-fluorouracils and ionizing radiations:NF-kB implication in the radiosensitivity and spontaneous apoptosis; Arrets du cycle cellulaire et induction d'apoptose pour les lignees de carcinome humain de la tete et du cou HPV-18 positives, apres exposition au 5-fluorouracile et aux radiations ionisantes: implication de NF-kB dans la radiosensibilite et l'apoptose spontanee}
author = {Didelot, C}
abstractNote = {The P-53 protein holds an important contribution in the control of the cell cycle as well as the apoptosis control. But in numerous cancers the P-53 protein functionality is blocked by mutations or by its gene obliteration. The distribution of cells in the cell cycle as well as the apoptosis induction have been studied after exposure to 5-Fluorouracils (5-F.U.) or ionizing radiations. The two types of stress can induce dependent P-53 apoptosis after 5-F.U. exposure and independent P-53 apoptosis after ionizing radiation exposure. The P-53 protein is not the only one to have an important part in the cell cycle and apoptosis control, the transcription factor is important as well as the cells sensitivity to a stress such ionizing radiation. This could open new approaches of increasing the biological effects of ionizing radiations. (N.C.)}
place = {France}
year = {2002}
month = {Apr}
}