Abstract
Tomographic breast imaging techniques can potentially improve detection and diagnosis of cancer in women with radiodense and/or fibrocystic breasts. We have developed a high-resolution positron emission mammography/tomography imaging and biopsy device (called PEM/PET) to detect and guide the biopsy of suspicious breast lesions. PET images are acquired to detect suspicious focal uptake of the radiotracer and guide biopsy of the area. Limited-angle PEM images could then be used to verify the biopsy needle position prior to tissue sampling. The PEM/PET scanner consists of two sets of rotating planar detector heads. Each detector consists of a 4 x 3 array of Hamamatsu H8500 flat panel position sensitive photomultipliers (PSPMTs) coupled to a 96 x 72 array of 2 x 2 x 15 mm{sup 3} LYSO detector elements (pitch = 2.1 mm). Image reconstruction is performed with a three-dimensional, ordered set expectation maximization (OSEM) algorithm parallelized to run on a multi-processor computer system. The reconstructed field of view (FOV) is 15 x 15 x 15 cm{sup 3}. Initial phantom-based testing of the device is focusing upon its PET imaging capabilities. Specifically, spatial resolution and detection sensitivity were assessed. The results from these measurements yielded a spatial resolution at the center of the
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Raylman, Raymond R;
[1]
Majewski, Stan;
[2]
Smith, Mark F;
[2]
Proffitt, James;
[2]
Hammond, William;
[2]
Srinivasan, Amarnath;
[1]
McKisson, John;
[2]
Popov, Vladimir;
[2]
Weisenberger, Andrew;
[2]
Judy, Clifford O;
[3]
Kross, Brian;
[2]
Ramasubramanian, Srikanth;
[1]
Banta, Larry E;
[3]
Kinahan, Paul E;
[4]
Champley, Kyle
[4]
- Center for Advanced Imaging, Department of Radiology, West Virginia University, Morgantown, WV (United States)
- Thomas Jefferson National Accelerator Facility, Newport News, VA (United States)
- Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, WV (United States)
- Department of Radiology, University of Washington, Seattle, WA (United States)
Citation Formats
Raylman, Raymond R, Majewski, Stan, Smith, Mark F, Proffitt, James, Hammond, William, Srinivasan, Amarnath, McKisson, John, Popov, Vladimir, Weisenberger, Andrew, Judy, Clifford O, Kross, Brian, Ramasubramanian, Srikanth, Banta, Larry E, Kinahan, Paul E, and Champley, Kyle.
The positron emission mammography/tomography breast imaging and biopsy system (PEM/PET): design, construction and phantom-based measurements.
United Kingdom: N. p.,
2008.
Web.
doi:10.1088/0031-9155/53/3/009; COUNTRY OF INPUT: INTERNATIONAL ATOMIC ENERGY AGENCY (IAEA).
Raylman, Raymond R, Majewski, Stan, Smith, Mark F, Proffitt, James, Hammond, William, Srinivasan, Amarnath, McKisson, John, Popov, Vladimir, Weisenberger, Andrew, Judy, Clifford O, Kross, Brian, Ramasubramanian, Srikanth, Banta, Larry E, Kinahan, Paul E, & Champley, Kyle.
The positron emission mammography/tomography breast imaging and biopsy system (PEM/PET): design, construction and phantom-based measurements.
United Kingdom.
https://doi.org/10.1088/0031-9155/53/3/009; COUNTRY OF INPUT: INTERNATIONAL ATOMIC ENERGY AGENCY (IAEA)
Raylman, Raymond R, Majewski, Stan, Smith, Mark F, Proffitt, James, Hammond, William, Srinivasan, Amarnath, McKisson, John, Popov, Vladimir, Weisenberger, Andrew, Judy, Clifford O, Kross, Brian, Ramasubramanian, Srikanth, Banta, Larry E, Kinahan, Paul E, and Champley, Kyle.
2008.
"The positron emission mammography/tomography breast imaging and biopsy system (PEM/PET): design, construction and phantom-based measurements."
United Kingdom.
https://doi.org/10.1088/0031-9155/53/3/009; COUNTRY OF INPUT: INTERNATIONAL ATOMIC ENERGY AGENCY (IAEA).
@misc{etde_20996044,
title = {The positron emission mammography/tomography breast imaging and biopsy system (PEM/PET): design, construction and phantom-based measurements}
author = {Raylman, Raymond R, Majewski, Stan, Smith, Mark F, Proffitt, James, Hammond, William, Srinivasan, Amarnath, McKisson, John, Popov, Vladimir, Weisenberger, Andrew, Judy, Clifford O, Kross, Brian, Ramasubramanian, Srikanth, Banta, Larry E, Kinahan, Paul E, and Champley, Kyle}
abstractNote = {Tomographic breast imaging techniques can potentially improve detection and diagnosis of cancer in women with radiodense and/or fibrocystic breasts. We have developed a high-resolution positron emission mammography/tomography imaging and biopsy device (called PEM/PET) to detect and guide the biopsy of suspicious breast lesions. PET images are acquired to detect suspicious focal uptake of the radiotracer and guide biopsy of the area. Limited-angle PEM images could then be used to verify the biopsy needle position prior to tissue sampling. The PEM/PET scanner consists of two sets of rotating planar detector heads. Each detector consists of a 4 x 3 array of Hamamatsu H8500 flat panel position sensitive photomultipliers (PSPMTs) coupled to a 96 x 72 array of 2 x 2 x 15 mm{sup 3} LYSO detector elements (pitch = 2.1 mm). Image reconstruction is performed with a three-dimensional, ordered set expectation maximization (OSEM) algorithm parallelized to run on a multi-processor computer system. The reconstructed field of view (FOV) is 15 x 15 x 15 cm{sup 3}. Initial phantom-based testing of the device is focusing upon its PET imaging capabilities. Specifically, spatial resolution and detection sensitivity were assessed. The results from these measurements yielded a spatial resolution at the center of the FOV of 2.01 {+-} 0.09 mm (radial), 2.04 {+-} 0.08 mm (tangential) and 1.84 {+-} 0.07 mm (axial). At a radius of 7 cm from the center of the scanner, the results were 2.11 {+-} 0.08 mm (radial), 2.16 {+-} 0.07 mm (tangential) and 1.87 {+-} 0.08 mm (axial). Maximum system detection sensitivity of the scanner is 488.9 kcps {mu}Ci{sup -1} ml{sup -1} (6.88%). These promising findings indicate that PEM/PET may be an effective system for the detection and diagnosis of breast cancer.}
doi = {10.1088/0031-9155/53/3/009; COUNTRY OF INPUT: INTERNATIONAL ATOMIC ENERGY AGENCY (IAEA)}
journal = []
issue = {3}
volume = {53}
place = {United Kingdom}
year = {2008}
month = {Feb}
}
title = {The positron emission mammography/tomography breast imaging and biopsy system (PEM/PET): design, construction and phantom-based measurements}
author = {Raylman, Raymond R, Majewski, Stan, Smith, Mark F, Proffitt, James, Hammond, William, Srinivasan, Amarnath, McKisson, John, Popov, Vladimir, Weisenberger, Andrew, Judy, Clifford O, Kross, Brian, Ramasubramanian, Srikanth, Banta, Larry E, Kinahan, Paul E, and Champley, Kyle}
abstractNote = {Tomographic breast imaging techniques can potentially improve detection and diagnosis of cancer in women with radiodense and/or fibrocystic breasts. We have developed a high-resolution positron emission mammography/tomography imaging and biopsy device (called PEM/PET) to detect and guide the biopsy of suspicious breast lesions. PET images are acquired to detect suspicious focal uptake of the radiotracer and guide biopsy of the area. Limited-angle PEM images could then be used to verify the biopsy needle position prior to tissue sampling. The PEM/PET scanner consists of two sets of rotating planar detector heads. Each detector consists of a 4 x 3 array of Hamamatsu H8500 flat panel position sensitive photomultipliers (PSPMTs) coupled to a 96 x 72 array of 2 x 2 x 15 mm{sup 3} LYSO detector elements (pitch = 2.1 mm). Image reconstruction is performed with a three-dimensional, ordered set expectation maximization (OSEM) algorithm parallelized to run on a multi-processor computer system. The reconstructed field of view (FOV) is 15 x 15 x 15 cm{sup 3}. Initial phantom-based testing of the device is focusing upon its PET imaging capabilities. Specifically, spatial resolution and detection sensitivity were assessed. The results from these measurements yielded a spatial resolution at the center of the FOV of 2.01 {+-} 0.09 mm (radial), 2.04 {+-} 0.08 mm (tangential) and 1.84 {+-} 0.07 mm (axial). At a radius of 7 cm from the center of the scanner, the results were 2.11 {+-} 0.08 mm (radial), 2.16 {+-} 0.07 mm (tangential) and 1.87 {+-} 0.08 mm (axial). Maximum system detection sensitivity of the scanner is 488.9 kcps {mu}Ci{sup -1} ml{sup -1} (6.88%). These promising findings indicate that PEM/PET may be an effective system for the detection and diagnosis of breast cancer.}
doi = {10.1088/0031-9155/53/3/009; COUNTRY OF INPUT: INTERNATIONAL ATOMIC ENERGY AGENCY (IAEA)}
journal = []
issue = {3}
volume = {53}
place = {United Kingdom}
year = {2008}
month = {Feb}
}