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SNP analyses of growth factor genes EGF, TGF{beta}-1, and HGF reveal haplotypic association of EGF with autism

Abstract

Autism is a pervasive neurodevelopmental disorder diagnosed in early childhood. Growth factors have been found to play a key role in the cellular differentiation and proliferation of the central and peripheral nervous systems. Epidermal growth factor (EGF) is detected in several regions of the developing and adult brain, where, it enhances the differentiation, maturation, and survival of a variety of neurons. Transforming growth factor-{beta} (TGF{beta}) isoforms play an important role in neuronal survival, and the hepatocyte growth factor (HGF) has been shown to exhibit neurotrophic activity. We examined the association of EGF, TGF{beta}1, and HGF genes with autism, in a trio association study, using DNA samples from families recruited to the Autism Genetic Resource Exchange; 252 trios with a male offspring scored for autism were selected for the study. Transmission disequilibrium test revealed significant haplotypic association of EGF with autism. No significant SNP or haplotypic associations were observed for TGF{beta}1 or HGF. Given the role of EGF in brain and neuronal development, we suggest a possible role of EGF in the pathogenesis of autism.
Authors:
Toyoda, Takao; Thanseem, Ismail; Kawai, Masayoshi; Sekine, Yoshimoto; [1]  Nakamura, Kazuhiko; Anitha, Ayyappan; Suda, Shiro; [1]  Yamada, Kazuo; [2]  Tsujii, Masatsugu; [3]  Iwayama, Yoshimi; Hattori, Eiji; Toyota, Tomoko; Yoshikawa, Takeo; [2]  Miyachi, Taishi; Tsuchiya, Kenji; Sugihara, Gen-ichi; Matsuzaki, Hideo; [4]  Iwata, Yasuhide; Suzuki, Katsuaki; [1]  Mori, Norio; [1]  Ouchi, Yasuomi; [4]  Sugiyama, Toshiro; [5]  Takei, Nori [4] 
  1. Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu 431-3192 (Japan)
  2. Laboratory of Molecular Psychiatry, RIKEN Brain Science Institute, Saitama (Japan)
  3. Faculty of Sociology, Chukyo University, Toyota, Aichi (Japan)
  4. The Osaka-Hamamatsu Joint Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu (Japan)
  5. Aichi Children's Health and Medical Center, Obu, Aichi (Japan)
Publication Date:
Sep 07, 2007
Product Type:
Journal Article
Resource Relation:
Journal Name: Biochemical and Biophysical Research Communications; Journal Volume: 360; Journal Issue: 4; Other Information: DOI: 10.1016/j.bbrc.2007.06.051; PII: S0006-291X(07)01255-7; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Subject:
60 APPLIED LIFE SCIENCES; BRAIN; CELL PROLIFERATION; DNA; GENES; GROWTH FACTORS; MATURATION; NERVE CELLS; PATHOGENESIS; PROGENY
OSTI ID:
20991519
Country of Origin:
United States
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0006-291X; BBRCA9; TRN: US07R2314014908
Submitting Site:
INIS
Size:
page(s) 715-720
Announcement Date:
Mar 27, 2008

Citation Formats

Toyoda, Takao, Thanseem, Ismail, Kawai, Masayoshi, Sekine, Yoshimoto, Nakamura, Kazuhiko, Anitha, Ayyappan, Suda, Shiro, Yamada, Kazuo, Tsujii, Masatsugu, Iwayama, Yoshimi, Hattori, Eiji, Toyota, Tomoko, Yoshikawa, Takeo, Miyachi, Taishi, Tsuchiya, Kenji, Sugihara, Gen-ichi, Matsuzaki, Hideo, Iwata, Yasuhide, Suzuki, Katsuaki, Mori, Norio, Ouchi, Yasuomi, Sugiyama, Toshiro, and Takei, Nori. SNP analyses of growth factor genes EGF, TGF{beta}-1, and HGF reveal haplotypic association of EGF with autism. United States: N. p., 2007. Web. doi:10.1016/j.bbrc.2007.06.051.
Toyoda, Takao, Thanseem, Ismail, Kawai, Masayoshi, Sekine, Yoshimoto, Nakamura, Kazuhiko, Anitha, Ayyappan, Suda, Shiro, Yamada, Kazuo, Tsujii, Masatsugu, Iwayama, Yoshimi, Hattori, Eiji, Toyota, Tomoko, Yoshikawa, Takeo, Miyachi, Taishi, Tsuchiya, Kenji, Sugihara, Gen-ichi, Matsuzaki, Hideo, Iwata, Yasuhide, Suzuki, Katsuaki, Mori, Norio, Ouchi, Yasuomi, Sugiyama, Toshiro, & Takei, Nori. SNP analyses of growth factor genes EGF, TGF{beta}-1, and HGF reveal haplotypic association of EGF with autism. United States. doi:10.1016/j.bbrc.2007.06.051.
Toyoda, Takao, Thanseem, Ismail, Kawai, Masayoshi, Sekine, Yoshimoto, Nakamura, Kazuhiko, Anitha, Ayyappan, Suda, Shiro, Yamada, Kazuo, Tsujii, Masatsugu, Iwayama, Yoshimi, Hattori, Eiji, Toyota, Tomoko, Yoshikawa, Takeo, Miyachi, Taishi, Tsuchiya, Kenji, Sugihara, Gen-ichi, Matsuzaki, Hideo, Iwata, Yasuhide, Suzuki, Katsuaki, Mori, Norio, Ouchi, Yasuomi, Sugiyama, Toshiro, and Takei, Nori. 2007. "SNP analyses of growth factor genes EGF, TGF{beta}-1, and HGF reveal haplotypic association of EGF with autism." United States. doi:10.1016/j.bbrc.2007.06.051. https://www.osti.gov/servlets/purl/10.1016/j.bbrc.2007.06.051.
@misc{etde_20991519,
title = {SNP analyses of growth factor genes EGF, TGF{beta}-1, and HGF reveal haplotypic association of EGF with autism}
author = {Toyoda, Takao, Thanseem, Ismail, Kawai, Masayoshi, Sekine, Yoshimoto, Nakamura, Kazuhiko, Anitha, Ayyappan, Suda, Shiro, Yamada, Kazuo, Tsujii, Masatsugu, Iwayama, Yoshimi, Hattori, Eiji, Toyota, Tomoko, Yoshikawa, Takeo, Miyachi, Taishi, Tsuchiya, Kenji, Sugihara, Gen-ichi, Matsuzaki, Hideo, Iwata, Yasuhide, Suzuki, Katsuaki, Mori, Norio, Ouchi, Yasuomi, Sugiyama, Toshiro, and Takei, Nori}
abstractNote = {Autism is a pervasive neurodevelopmental disorder diagnosed in early childhood. Growth factors have been found to play a key role in the cellular differentiation and proliferation of the central and peripheral nervous systems. Epidermal growth factor (EGF) is detected in several regions of the developing and adult brain, where, it enhances the differentiation, maturation, and survival of a variety of neurons. Transforming growth factor-{beta} (TGF{beta}) isoforms play an important role in neuronal survival, and the hepatocyte growth factor (HGF) has been shown to exhibit neurotrophic activity. We examined the association of EGF, TGF{beta}1, and HGF genes with autism, in a trio association study, using DNA samples from families recruited to the Autism Genetic Resource Exchange; 252 trios with a male offspring scored for autism were selected for the study. Transmission disequilibrium test revealed significant haplotypic association of EGF with autism. No significant SNP or haplotypic associations were observed for TGF{beta}1 or HGF. Given the role of EGF in brain and neuronal development, we suggest a possible role of EGF in the pathogenesis of autism.}
doi = {10.1016/j.bbrc.2007.06.051}
journal = {Biochemical and Biophysical Research Communications}
issue = {4}
volume = {360}
place = {United States}
year = {2007}
month = {Sep}
}