Abstract
Impaired pre-synaptic noradrenaline uptake-1 mechanism has been reported in a swine model of hibernating myocardium (HM). To ascertain whether adrenergic neuroeffector abnormalities are present in human HM, we combined functional measurements in vivo using cardiovascular magnetic resonance (CMR) and positron emission tomography (PET) to assess pre- and post-synaptic sympathetic function. Twelve patients with coronary artery disease and chronic left ventricular (LV) dysfunction underwent CMR at baseline and 6 months after bypass for assessment of regional and global LV function and identification of segments with reversible dysfunction. Before surgery, myocardial noradrenaline uptake-1 ([{sup 11}C]meta-hydroxy-ephedrine; HED) and {beta}-adrenoceptor ({beta}-AR) density ([{sup 11}C]CGP-12177) were measured with PET. Patient PET data were compared with those in 18 healthy controls. The volume of distribution (V{sub d}) of HED in HM (47.95{+-}28.05 ml/g) and infarcted myocardium (42.69{+-}25.76 ml/g) was significantly reduced compared with controls (66.09{+-}14.48 ml/g). The V{sub d} of HED in normal myocardium (49.93{+-}20.48 ml/g) of patients was also lower than that in controls and the difference was close to statistical significance (p=0.06). Myocardial {beta}-AR density was significantly lower in HM (5.49{+-}2.35 pmol/g), infarcted (4.82{+-}2.61 pmol/g) and normal (5.86{+-}1.81 pmol/g) segments of patients compared with healthy controls (8.61{+-}1.32 pmol/g). Noradrenaline uptake-1 mechanism and {beta}-AR density
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John, Anna S;
Pepper, John R;
Dreyfus, Gilles D;
Pennell, Dudley J;
[1]
Mongillo, Marco;
Khan, Muhammad T;
[2]
Depre, Christophe;
[3]
University of Medicine and Dentistry New Jersey, Cardiovascular Research Institute, Department of Medicine, New Jersey, NJ (United States)];
Rimoldi, Ornella E;
[1]
Imperial College, Hammersmith Hospital, Medical Research Council Clinical Sciences Centre, London (United Kingdom);
New York Medical College, Cardiovascular Research Institute, Department of Medicine, Valhalla, NY (United States)];
Camici, Paolo G;
[1]
Imperial College, Hammersmith Hospital, Medical Research Council Clinical Sciences Centre, London (United Kingdom)]
- Imperial College, Hammersmith Hospital, National Heart and Lung Institute, London (United Kingdom)
- Imperial College, Hammersmith Hospital, Medical Research Council Clinical Sciences Centre, London (United Kingdom)
- University of Medicine and Dentistry New Jersey, Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, New Jersey, NJ (United States)
Citation Formats
John, Anna S, Pepper, John R, Dreyfus, Gilles D, Pennell, Dudley J, Mongillo, Marco, Khan, Muhammad T, Depre, Christophe, University of Medicine and Dentistry New Jersey, Cardiovascular Research Institute, Department of Medicine, New Jersey, NJ (United States)], Rimoldi, Ornella E, Imperial College, Hammersmith Hospital, Medical Research Council Clinical Sciences Centre, London (United Kingdom), New York Medical College, Cardiovascular Research Institute, Department of Medicine, Valhalla, NY (United States)], Camici, Paolo G, and Imperial College, Hammersmith Hospital, Medical Research Council Clinical Sciences Centre, London (United Kingdom)].
Pre- and post-synaptic sympathetic function in human hibernating myocardium.
Germany: N. p.,
2007.
Web.
doi:10.1007/S00259-007-0507-1.
John, Anna S, Pepper, John R, Dreyfus, Gilles D, Pennell, Dudley J, Mongillo, Marco, Khan, Muhammad T, Depre, Christophe, University of Medicine and Dentistry New Jersey, Cardiovascular Research Institute, Department of Medicine, New Jersey, NJ (United States)], Rimoldi, Ornella E, Imperial College, Hammersmith Hospital, Medical Research Council Clinical Sciences Centre, London (United Kingdom), New York Medical College, Cardiovascular Research Institute, Department of Medicine, Valhalla, NY (United States)], Camici, Paolo G, & Imperial College, Hammersmith Hospital, Medical Research Council Clinical Sciences Centre, London (United Kingdom)].
Pre- and post-synaptic sympathetic function in human hibernating myocardium.
Germany.
https://doi.org/10.1007/S00259-007-0507-1
John, Anna S, Pepper, John R, Dreyfus, Gilles D, Pennell, Dudley J, Mongillo, Marco, Khan, Muhammad T, Depre, Christophe, University of Medicine and Dentistry New Jersey, Cardiovascular Research Institute, Department of Medicine, New Jersey, NJ (United States)], Rimoldi, Ornella E, Imperial College, Hammersmith Hospital, Medical Research Council Clinical Sciences Centre, London (United Kingdom), New York Medical College, Cardiovascular Research Institute, Department of Medicine, Valhalla, NY (United States)], Camici, Paolo G, and Imperial College, Hammersmith Hospital, Medical Research Council Clinical Sciences Centre, London (United Kingdom)].
2007.
"Pre- and post-synaptic sympathetic function in human hibernating myocardium."
Germany.
https://doi.org/10.1007/S00259-007-0507-1.
@misc{etde_20986304,
title = {Pre- and post-synaptic sympathetic function in human hibernating myocardium}
author = {John, Anna S, Pepper, John R, Dreyfus, Gilles D, Pennell, Dudley J, Mongillo, Marco, Khan, Muhammad T, Depre, Christophe, University of Medicine and Dentistry New Jersey, Cardiovascular Research Institute, Department of Medicine, New Jersey, NJ (United States)], Rimoldi, Ornella E, Imperial College, Hammersmith Hospital, Medical Research Council Clinical Sciences Centre, London (United Kingdom), New York Medical College, Cardiovascular Research Institute, Department of Medicine, Valhalla, NY (United States)], Camici, Paolo G, and Imperial College, Hammersmith Hospital, Medical Research Council Clinical Sciences Centre, London (United Kingdom)]}
abstractNote = {Impaired pre-synaptic noradrenaline uptake-1 mechanism has been reported in a swine model of hibernating myocardium (HM). To ascertain whether adrenergic neuroeffector abnormalities are present in human HM, we combined functional measurements in vivo using cardiovascular magnetic resonance (CMR) and positron emission tomography (PET) to assess pre- and post-synaptic sympathetic function. Twelve patients with coronary artery disease and chronic left ventricular (LV) dysfunction underwent CMR at baseline and 6 months after bypass for assessment of regional and global LV function and identification of segments with reversible dysfunction. Before surgery, myocardial noradrenaline uptake-1 ([{sup 11}C]meta-hydroxy-ephedrine; HED) and {beta}-adrenoceptor ({beta}-AR) density ([{sup 11}C]CGP-12177) were measured with PET. Patient PET data were compared with those in 18 healthy controls. The volume of distribution (V{sub d}) of HED in HM (47.95{+-}28.05 ml/g) and infarcted myocardium (42.69{+-}25.76 ml/g) was significantly reduced compared with controls (66.09{+-}14.48 ml/g). The V{sub d} of HED in normal myocardium (49.93{+-}20.48 ml/g) of patients was also lower than that in controls and the difference was close to statistical significance (p=0.06). Myocardial {beta}-AR density was significantly lower in HM (5.49{+-}2.35 pmol/g), infarcted (4.82{+-}2.61 pmol/g) and normal (5.86{+-}1.81 pmol/g) segments of patients compared with healthy controls (8.61{+-}1.32 pmol/g). Noradrenaline uptake-1 mechanism and {beta}-AR density are reduced in the myocardium of patients with chronic LV dysfunction and evidence of HM. The increased sympathetic activity to the heart in these patients is a generalised rather than regional phenomenon which is likely to contribute to the remodelling process of the whole LV rather than playing a causative role in HM. (orig.)}
doi = {10.1007/S00259-007-0507-1}
journal = []
issue = {12}
volume = {34}
place = {Germany}
year = {2007}
month = {Dec}
}
title = {Pre- and post-synaptic sympathetic function in human hibernating myocardium}
author = {John, Anna S, Pepper, John R, Dreyfus, Gilles D, Pennell, Dudley J, Mongillo, Marco, Khan, Muhammad T, Depre, Christophe, University of Medicine and Dentistry New Jersey, Cardiovascular Research Institute, Department of Medicine, New Jersey, NJ (United States)], Rimoldi, Ornella E, Imperial College, Hammersmith Hospital, Medical Research Council Clinical Sciences Centre, London (United Kingdom), New York Medical College, Cardiovascular Research Institute, Department of Medicine, Valhalla, NY (United States)], Camici, Paolo G, and Imperial College, Hammersmith Hospital, Medical Research Council Clinical Sciences Centre, London (United Kingdom)]}
abstractNote = {Impaired pre-synaptic noradrenaline uptake-1 mechanism has been reported in a swine model of hibernating myocardium (HM). To ascertain whether adrenergic neuroeffector abnormalities are present in human HM, we combined functional measurements in vivo using cardiovascular magnetic resonance (CMR) and positron emission tomography (PET) to assess pre- and post-synaptic sympathetic function. Twelve patients with coronary artery disease and chronic left ventricular (LV) dysfunction underwent CMR at baseline and 6 months after bypass for assessment of regional and global LV function and identification of segments with reversible dysfunction. Before surgery, myocardial noradrenaline uptake-1 ([{sup 11}C]meta-hydroxy-ephedrine; HED) and {beta}-adrenoceptor ({beta}-AR) density ([{sup 11}C]CGP-12177) were measured with PET. Patient PET data were compared with those in 18 healthy controls. The volume of distribution (V{sub d}) of HED in HM (47.95{+-}28.05 ml/g) and infarcted myocardium (42.69{+-}25.76 ml/g) was significantly reduced compared with controls (66.09{+-}14.48 ml/g). The V{sub d} of HED in normal myocardium (49.93{+-}20.48 ml/g) of patients was also lower than that in controls and the difference was close to statistical significance (p=0.06). Myocardial {beta}-AR density was significantly lower in HM (5.49{+-}2.35 pmol/g), infarcted (4.82{+-}2.61 pmol/g) and normal (5.86{+-}1.81 pmol/g) segments of patients compared with healthy controls (8.61{+-}1.32 pmol/g). Noradrenaline uptake-1 mechanism and {beta}-AR density are reduced in the myocardium of patients with chronic LV dysfunction and evidence of HM. The increased sympathetic activity to the heart in these patients is a generalised rather than regional phenomenon which is likely to contribute to the remodelling process of the whole LV rather than playing a causative role in HM. (orig.)}
doi = {10.1007/S00259-007-0507-1}
journal = []
issue = {12}
volume = {34}
place = {Germany}
year = {2007}
month = {Dec}
}