Abstract
Three methods for {sup 18}F-labeling of dimeric and tetrameric neurotensin(8-13) derivatives were evaluated with respect to the labeling yield and the required peptide amounts. Labeling using N-succinimidyl-4-[{sup 18}F]fluorobenzoate ([{sup 18}F]SFB) gave low radiochemical yield for the dimeric peptides. Coupling of the tetramer with [{sup 18}F]SFB was not successful. High yields were obtained for labeling of the aminooxy-functionalized neurotensin(8-13) dimer using 4-[{sup 18}F]fluorobenzaldehyde ([{sup 18}F]FBA) whilst coupling of the corresponding tetramer gave only low yields. Labeling of sulfydryl-functionalized neurotensin(8-13) derivatives using the maleinimide 4-[{sup 18}F]fluorobenzaldehyde-O-[6-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-hexyl] -oxime ([{sup 18}F]FBAM) resulted in high radiochemical yields for both, the dimer and the tetramer. Therefore, [{sup 18}F]FBAM seems to be the most suitable {sup 18}F-labeling agent for multivalent neurotensin(8-13) derivatives.
Hultsch, Christina;
[1]
Berndt, Mathias;
[1]
Bergmann, Ralf;
[1]
Wuest, Frank
[1]
- Institute of Radiopharmacy, Research Center Rossendorf, P.O. Box 51 01 19, D-01314 Dresden (Germany)
Citation Formats
Hultsch, Christina, Berndt, Mathias, Bergmann, Ralf, and Wuest, Frank.
Radiolabeling of multimeric neurotensin(8-13) analogs with the short-lived positron emitter fluorine-18.
United Kingdom: N. p.,
2007.
Web.
doi:10.1016/j.apradiso.2007.02.004.
Hultsch, Christina, Berndt, Mathias, Bergmann, Ralf, & Wuest, Frank.
Radiolabeling of multimeric neurotensin(8-13) analogs with the short-lived positron emitter fluorine-18.
United Kingdom.
https://doi.org/10.1016/j.apradiso.2007.02.004
Hultsch, Christina, Berndt, Mathias, Bergmann, Ralf, and Wuest, Frank.
2007.
"Radiolabeling of multimeric neurotensin(8-13) analogs with the short-lived positron emitter fluorine-18."
United Kingdom.
https://doi.org/10.1016/j.apradiso.2007.02.004.
@misc{etde_20978791,
title = {Radiolabeling of multimeric neurotensin(8-13) analogs with the short-lived positron emitter fluorine-18}
author = {Hultsch, Christina, Berndt, Mathias, Bergmann, Ralf, and Wuest, Frank}
abstractNote = {Three methods for {sup 18}F-labeling of dimeric and tetrameric neurotensin(8-13) derivatives were evaluated with respect to the labeling yield and the required peptide amounts. Labeling using N-succinimidyl-4-[{sup 18}F]fluorobenzoate ([{sup 18}F]SFB) gave low radiochemical yield for the dimeric peptides. Coupling of the tetramer with [{sup 18}F]SFB was not successful. High yields were obtained for labeling of the aminooxy-functionalized neurotensin(8-13) dimer using 4-[{sup 18}F]fluorobenzaldehyde ([{sup 18}F]FBA) whilst coupling of the corresponding tetramer gave only low yields. Labeling of sulfydryl-functionalized neurotensin(8-13) derivatives using the maleinimide 4-[{sup 18}F]fluorobenzaldehyde-O-[6-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-hexyl] -oxime ([{sup 18}F]FBAM) resulted in high radiochemical yields for both, the dimer and the tetramer. Therefore, [{sup 18}F]FBAM seems to be the most suitable {sup 18}F-labeling agent for multivalent neurotensin(8-13) derivatives.}
doi = {10.1016/j.apradiso.2007.02.004}
journal = []
issue = {7}
volume = {65}
place = {United Kingdom}
year = {2007}
month = {Jul}
}
title = {Radiolabeling of multimeric neurotensin(8-13) analogs with the short-lived positron emitter fluorine-18}
author = {Hultsch, Christina, Berndt, Mathias, Bergmann, Ralf, and Wuest, Frank}
abstractNote = {Three methods for {sup 18}F-labeling of dimeric and tetrameric neurotensin(8-13) derivatives were evaluated with respect to the labeling yield and the required peptide amounts. Labeling using N-succinimidyl-4-[{sup 18}F]fluorobenzoate ([{sup 18}F]SFB) gave low radiochemical yield for the dimeric peptides. Coupling of the tetramer with [{sup 18}F]SFB was not successful. High yields were obtained for labeling of the aminooxy-functionalized neurotensin(8-13) dimer using 4-[{sup 18}F]fluorobenzaldehyde ([{sup 18}F]FBA) whilst coupling of the corresponding tetramer gave only low yields. Labeling of sulfydryl-functionalized neurotensin(8-13) derivatives using the maleinimide 4-[{sup 18}F]fluorobenzaldehyde-O-[6-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-hexyl] -oxime ([{sup 18}F]FBAM) resulted in high radiochemical yields for both, the dimer and the tetramer. Therefore, [{sup 18}F]FBAM seems to be the most suitable {sup 18}F-labeling agent for multivalent neurotensin(8-13) derivatives.}
doi = {10.1016/j.apradiso.2007.02.004}
journal = []
issue = {7}
volume = {65}
place = {United Kingdom}
year = {2007}
month = {Jul}
}