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Subclinical hyperthyroidism (Sh) in atomic-bomb survivors in Japan

Journal Article:

Abstract

Full text: Purpose/Background Subclinical hyperthyroidism (Sh) is defined as a biochemical abnormality characterized by a subnormal level of TSH with otherwise normal thyroid tests (F T{sub 3}, F T{sub 4}) and no clinical symptoms. There are only a small number of cross-sectional studies on the prevalence of Sh. With the improvement of the sensitivity of TSH assay, it has become possible to survey the clinical significance of Sh. With regard to both Sh and subclinical hypothyroidism, discussions are being focused on such as the necessity of treatment. In order to elucidate the clinical significance of Sh, examination data of A-bomb survivors in Hiroshima and Nagasaki were analyzed. Subjects and Method Between 2000 and 2003, of 4,090 A-bomb survivors (1,352 males and 2,738 females with average age of 70.7), 75 individuals (1.83%) with Sh were found who had normal Free T{sub 4} (0.71{approx}1.51 ng/dL) and TSH<0.45 m U/L. Analysis was limited to those who had not taken antithyroid drugs or thyroxin, and the Sh group (n=35; 9 males and 26 females) was compared with a control group with TSH:0.45{approx}4.5 m U/L (Group C; N=3,243; 1,109 males and 2,134 females). Result: Nine individuals had TSH<0.1 m U/L. In the Sh group, six  More>>
Authors:
Ashizawa, K; Imaizumi, M; Usa, T; Tominaga, T; Hida, A; Ejima, E; Neriishi, K; Soda, M; Fujiwara, S; Maeda, R; Akahoshi, M; Nagataki, S; Eguchi, K [1] 
  1. Radiation Effects Research Foundation, Nagasaki (Japan). Nagasaki Branch
Publication Date:
Jul 01, 2005
Product Type:
Journal Article
Resource Relation:
Journal Name: Thyroid; Journal Volume: 15; Journal Issue: suppl.1; Conference: 13. International thyroid congress, Buenos Aires (Argentina), 30 Oct - 4 Nov 2005; Other Information: Poster presentation; Abstract only
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; A-BOMB SURVIVORS; ANTIBODIES; ANTITHYROID DRUGS; ELECTROCARDIOGRAMS; HIROSHIMA; HYPERTENSION; HYPERTHYROIDISM; HYPOTHYROIDISM; NAGASAKI; NUCLEAR WEAPONS; THYROID; TSH
OSTI ID:
20978556
Country of Origin:
Argentina
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1050-7256; TRN: AR07C0117007264
Availability:
Also available from: 'http://www.13itc.org/information.html';INIS
Submitting Site:
INIS
Size:
page(s) S-75
Announcement Date:
Mar 07, 2008

Journal Article:

Citation Formats

Ashizawa, K, Imaizumi, M, Usa, T, Tominaga, T, Hida, A, Ejima, E, Neriishi, K, Soda, M, Fujiwara, S, Maeda, R, Akahoshi, M, Nagataki, S, and Eguchi, K. Subclinical hyperthyroidism (Sh) in atomic-bomb survivors in Japan. Argentina: N. p., 2005. Web.
Ashizawa, K, Imaizumi, M, Usa, T, Tominaga, T, Hida, A, Ejima, E, Neriishi, K, Soda, M, Fujiwara, S, Maeda, R, Akahoshi, M, Nagataki, S, & Eguchi, K. Subclinical hyperthyroidism (Sh) in atomic-bomb survivors in Japan. Argentina.
Ashizawa, K, Imaizumi, M, Usa, T, Tominaga, T, Hida, A, Ejima, E, Neriishi, K, Soda, M, Fujiwara, S, Maeda, R, Akahoshi, M, Nagataki, S, and Eguchi, K. 2005. "Subclinical hyperthyroidism (Sh) in atomic-bomb survivors in Japan." Argentina.
@misc{etde_20978556,
title = {Subclinical hyperthyroidism (Sh) in atomic-bomb survivors in Japan}
author = {Ashizawa, K, Imaizumi, M, Usa, T, Tominaga, T, Hida, A, Ejima, E, Neriishi, K, Soda, M, Fujiwara, S, Maeda, R, Akahoshi, M, Nagataki, S, and Eguchi, K}
abstractNote = {Full text: Purpose/Background Subclinical hyperthyroidism (Sh) is defined as a biochemical abnormality characterized by a subnormal level of TSH with otherwise normal thyroid tests (F T{sub 3}, F T{sub 4}) and no clinical symptoms. There are only a small number of cross-sectional studies on the prevalence of Sh. With the improvement of the sensitivity of TSH assay, it has become possible to survey the clinical significance of Sh. With regard to both Sh and subclinical hypothyroidism, discussions are being focused on such as the necessity of treatment. In order to elucidate the clinical significance of Sh, examination data of A-bomb survivors in Hiroshima and Nagasaki were analyzed. Subjects and Method Between 2000 and 2003, of 4,090 A-bomb survivors (1,352 males and 2,738 females with average age of 70.7), 75 individuals (1.83%) with Sh were found who had normal Free T{sub 4} (0.71{approx}1.51 ng/dL) and TSH<0.45 m U/L. Analysis was limited to those who had not taken antithyroid drugs or thyroxin, and the Sh group (n=35; 9 males and 26 females) was compared with a control group with TSH:0.45{approx}4.5 m U/L (Group C; N=3,243; 1,109 males and 2,134 females). Result: Nine individuals had TSH<0.1 m U/L. In the Sh group, six individuals were TPO antibody-positive (17%) and 14 were TG antibody-positive (40%); hence, TG antibody-positive was significantly greater in number (p=0.0096). Hematological biochemical tests showed no significant difference between the two groups. Electrocardiograms indicated that more individuals had atrial fibrillation [p=0.028; Odds ratio (OR)=3.98; 95% Confidential interval (CI)=1.2-13.7] or ventricular premature contraction [p=0.016; OR=3.29; 95% CI=1.3-8.6] in the Sh group. In terms of the presence or absence of diabetes, dyslipidemia, hypertension, and hyperuricemia, there was no difference between the two groups. One individual from the Sh group was confirmed to have Graves' disease two years later. Conclusion: Since more individuals in the Sh group were thyroid autoantibody-positive or had abnormalities in their electrocardiograms, careful follow-up of this group is essential. (author)}
journal = {Thyroid}
issue = {suppl.1}
volume = {15}
place = {Argentina}
year = {2005}
month = {Jul}
}