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The use of tracers in the study of the ionic permeability of the nerve; Utilisation des indicateurs nucleaires dans l'etude de la permeabilite ionique du nerf

Abstract

The use of the radioactive tracers {sup 24}Na and {sup 42}K, and the electrophysiological fine study carried out on the plant Cephalopods nervous cells have made it possible, during ten years, to study the relationships between the electrical phenomena observed during the propagation of the nervous impulse and the ionic movements which occur at the cell membrane between the intra- and extra-cellular media. In the state of rest, the nerve fibres present a certain permeability towards sodium and potassium, a permeability which allows the renewal, from the extra-cellular medium, of the cations contained in the cytoplasm. At the moment of the passage of the nervous impulse, it is possible to demonstrate a temporary increase in the permeability towards the sodium which causes the entry of Na{sup +} ions into the nerve fibre, whilst, a few milliseconds later, the increase in the potassium permeability causes the departure of an equivalent quantity of K{sup +} ions. A recovery phase follows the passage of the nervous impulse, during which the original ionic conditions are re-established. If the potassium movements can be considered as passive, the expulsion of Na{sup +} requires, on the part of the cell, the use of a part of the  More>>
Authors:
Guinnebault, M [1] 
  1. Commissariat a l'Energie Atomique, Saclay (France). Centre d'Etudes Nucleaires
Publication Date:
Jul 01, 1961
Product Type:
Technical Report
Report Number:
CEA-R-1902
Resource Relation:
Other Information: 3 refs
Subject:
60 APPLIED LIFE SCIENCES; ATP; CELL MEMBRANES; DIFFUSION; ELECTRIC POTENTIAL; ELECTROPHYSIOLOGY; MEMBRANE TRANSPORT; NERVE CELLS; PERMEABILITY; POTASSIUM 42; POTASSIUM IONS; SODIUM 24; SODIUM IONS; TRACER TECHNIQUES
OSTI ID:
20972206
Research Organizations:
CEA Saclay, 91 - Gif-sur-Yvette (France)
Country of Origin:
France
Language:
French
Other Identifying Numbers:
TRN: FR07R1902001526
Availability:
Available from INIS in electronic form
Submitting Site:
FRN
Size:
22 pages
Announcement Date:
Jan 17, 2008

Citation Formats

Guinnebault, M. The use of tracers in the study of the ionic permeability of the nerve; Utilisation des indicateurs nucleaires dans l'etude de la permeabilite ionique du nerf. France: N. p., 1961. Web.
Guinnebault, M. The use of tracers in the study of the ionic permeability of the nerve; Utilisation des indicateurs nucleaires dans l'etude de la permeabilite ionique du nerf. France.
Guinnebault, M. 1961. "The use of tracers in the study of the ionic permeability of the nerve; Utilisation des indicateurs nucleaires dans l'etude de la permeabilite ionique du nerf." France.
@misc{etde_20972206,
title = {The use of tracers in the study of the ionic permeability of the nerve; Utilisation des indicateurs nucleaires dans l'etude de la permeabilite ionique du nerf}
author = {Guinnebault, M}
abstractNote = {The use of the radioactive tracers {sup 24}Na and {sup 42}K, and the electrophysiological fine study carried out on the plant Cephalopods nervous cells have made it possible, during ten years, to study the relationships between the electrical phenomena observed during the propagation of the nervous impulse and the ionic movements which occur at the cell membrane between the intra- and extra-cellular media. In the state of rest, the nerve fibres present a certain permeability towards sodium and potassium, a permeability which allows the renewal, from the extra-cellular medium, of the cations contained in the cytoplasm. At the moment of the passage of the nervous impulse, it is possible to demonstrate a temporary increase in the permeability towards the sodium which causes the entry of Na{sup +} ions into the nerve fibre, whilst, a few milliseconds later, the increase in the potassium permeability causes the departure of an equivalent quantity of K{sup +} ions. A recovery phase follows the passage of the nervous impulse, during which the original ionic conditions are re-established. If the potassium movements can be considered as passive, the expulsion of Na{sup +} requires, on the part of the cell, the use of a part of the metabolic energy. (author) [French] L'utilisation des indicateurs radioactifs {sup 24}Na et {sup 42}K, et l'etude electrophysiologique fine realisee sur des cellules nerveuses geantes de Cephalopodes a permis, depuis une dizaine d'annees, d'etudier les rapports entre les phenomenes electriques observes lors de la propagation de l'influx nerveux et les mouvements ioniques qui s'effectuent au niveau de la membrane cellulaire entre milieux intracellulaire et extracellulaire. A l'etat de repos, les fibres nerveuses possedent pour le sodium et le potassium, une permeabilite qui permet le renouvellement, a partir du milieu extracellulaire des cations contenus dans le cytoplasme. Au moment du passage de l'influx nerveux, on peut mettre en evidence une augmentation transitoire de la permeabilite au sodium, qui provoque l'entree des ions Na{sup +} dans la fibre nerveuse, tandis que, quelques millisecondes plus tard, l'augmentation de la permeabilite au potassium provoque la sortie d'une quantite equivalente d'ions K{sup +}. Une phase de restauration suit le passage de l'influx nerveux, au cours de laquelle les conditions ioniques initiales sont retablies. Si les mouvements de potassium peuvent etre consideres comme passifs, l'expulsion du Na{sup +} requiert, de la part de la cellule, l'utilisation d'une partie de l'energie metabolique. (auteur)}
place = {France}
year = {1961}
month = {Jul}
}