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Study of the antithyroid and radioprotective properties of compounds of the 5 thione imidazolidines group; Etude des proprietes antithyroidiennes et radioprotectrices de composes de la famille des 5 thione imidazolidines

Abstract

Some compounds of the 5 thione imidazolidines group were synthesized by conventional or original methods, and this study is aimed at defining certain pharmacodynamic properties which these substances may be expected to show on the basis of their structure. The properties looked for are: - antithyroid activity, by studying the difference in iodine 131 fixation by the thyroid of rats previously treated or not with these materials; - radioprotective activity, by the comparative study of percentage survival; after 30 days, of mice subjected to a lethal dose of X radiation and having received or not, before irradiation, an intraperitoneal injection of the product under investigation. (author) [French] La synthese de quelques composes de la famille des 5 thione imidazolidines a ete realisee par des methodes classiques ou originales, et le but de ce travail est d'essayer de preciser certaines proprietes pharmacodynamiques que la structure de ces substances peut laisser prevoir. Les proprietes recherchees sont: - l'activite antithyroidienne par l'etude de la difference de la fixation de l'iode 131 par la thyroide de rats prealablement traites ou non par ces produits; - l'activite radioprotectrice par l'etude comparative du pourcentage de survie a 30 jours chez des souris soumises a une dose  More>>
Authors:
Rinaldi, R; Bernard, Y [1] 
  1. Commissariat a l'Energie Atomique, Grenoble (France).Centre d'Etudes Nucleaires
Publication Date:
Jul 01, 1961
Product Type:
Technical Report
Report Number:
CEA-R-1841
Resource Relation:
Conference: 79. Conference of the French Association for the Progress of Sciences, 79. congres de l'Association Francaise pour l'avancement des sciences, Grenoble (France), Jul 1960; Other Information: 7 refs
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; ANTITHYROID DRUGS; BIOASSAY; CHEMICAL PREPARATION; COMPARATIVE EVALUATIONS; IMIDAZOLES; INTRAPERITONEAL INJECTION; LABORATORY ANIMALS; LETHAL RADIATION DOSE; MICE; PERFORMANCE TESTING; PHARMACOLOGY; RADIOPROTECTIVE SUBSTANCES; RATS; SURVIVAL CURVES
OSTI ID:
20972176
Research Organizations:
CEA Grenoble, 38 (France)
Country of Origin:
France
Language:
French
Other Identifying Numbers:
TRN: FR07R1841001496
Availability:
Available from INIS in electronic form
Submitting Site:
FRN
Size:
17 pages
Announcement Date:
Jan 17, 2008

Citation Formats

Rinaldi, R, and Bernard, Y. Study of the antithyroid and radioprotective properties of compounds of the 5 thione imidazolidines group; Etude des proprietes antithyroidiennes et radioprotectrices de composes de la famille des 5 thione imidazolidines. France: N. p., 1961. Web.
Rinaldi, R, & Bernard, Y. Study of the antithyroid and radioprotective properties of compounds of the 5 thione imidazolidines group; Etude des proprietes antithyroidiennes et radioprotectrices de composes de la famille des 5 thione imidazolidines. France.
Rinaldi, R, and Bernard, Y. 1961. "Study of the antithyroid and radioprotective properties of compounds of the 5 thione imidazolidines group; Etude des proprietes antithyroidiennes et radioprotectrices de composes de la famille des 5 thione imidazolidines." France.
@misc{etde_20972176,
title = {Study of the antithyroid and radioprotective properties of compounds of the 5 thione imidazolidines group; Etude des proprietes antithyroidiennes et radioprotectrices de composes de la famille des 5 thione imidazolidines}
author = {Rinaldi, R, and Bernard, Y}
abstractNote = {Some compounds of the 5 thione imidazolidines group were synthesized by conventional or original methods, and this study is aimed at defining certain pharmacodynamic properties which these substances may be expected to show on the basis of their structure. The properties looked for are: - antithyroid activity, by studying the difference in iodine 131 fixation by the thyroid of rats previously treated or not with these materials; - radioprotective activity, by the comparative study of percentage survival; after 30 days, of mice subjected to a lethal dose of X radiation and having received or not, before irradiation, an intraperitoneal injection of the product under investigation. (author) [French] La synthese de quelques composes de la famille des 5 thione imidazolidines a ete realisee par des methodes classiques ou originales, et le but de ce travail est d'essayer de preciser certaines proprietes pharmacodynamiques que la structure de ces substances peut laisser prevoir. Les proprietes recherchees sont: - l'activite antithyroidienne par l'etude de la difference de la fixation de l'iode 131 par la thyroide de rats prealablement traites ou non par ces produits; - l'activite radioprotectrice par l'etude comparative du pourcentage de survie a 30 jours chez des souris soumises a une dose lethale de rayonnement X, et ayant recu ou non, avant irradiation une injection intraperitoneale du produit a etudier. (auteur)}
place = {France}
year = {1961}
month = {Jul}
}