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Some examples of the use of radioactive tracers in pharmacodynamic; Quelques exemples de l'emploi des traceurs radioactifs en pharmacodynamie

Abstract

The study of absorption, of distribution in the organism and of the elimination of a medicament has been greatly facilitated by the development of nuclear applications. In effect, the introduction into the molecule of one or several radioactive atoms makes it possible to follow the path and destination of minute quantities of the drug and to thus carry out analyses on the animal within limits of posology close to those of therapeutics. However the qualitative or quantitative methods used have certain limits and they must be compared amongst themselves and with others. Some examples will show : - the importance of the way of administering the drug on the changes in the distribution; - the quite relative selectivity of this latter; - and lastly, the different process involved in the elimination mechanisms. (author) [French] L'etude de l'absorption, de la repartition dans l'organisme et de l'elimination d'un medicament s'est trouvee grandement facilitee par le developpement des applications nucleaires. En effet, l'introduction dans une molecule d'un ou plusieurs atomes radioactifs permet de suivre le sort de quantites infimes de la drogue et de ce fait d'en effectuer l'analyse chez l'animal dans des limites de posologie se rapprochant de celles de la therapeutique.  More>>
Authors:
Cohen, Y [1] 
  1. Commissariat a l'Energie Atomique, Saclay (France).Centre d'Etudes Nucleaires
Publication Date:
Jul 01, 1960
Product Type:
Technical Report
Report Number:
CEA-R-1723
Resource Relation:
Other Information: 4 refs
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; AUTORADIOGRAPHY; BIOLOGICAL LOCALIZATION; CARBON 14 COMPOUNDS; CLEARANCE; COMPARATIVE EVALUATIONS; INTRAVENOUS INJECTION; METABOLISM; ORAL ADMINISTRATION; PHARMACOLOGY; RADIONUCLIDE ADMINISTRATION; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; SUBCUTANEOUS INJECTION; SULFUR 35; THERAPEUTIC USES; TISSUE DISTRIBUTION; TRACER TECHNIQUES
OSTI ID:
20967960
Research Organizations:
CEA Saclay, 91 - Gif-sur-Yvette (France)
Country of Origin:
France
Language:
French
Other Identifying Numbers:
TRN: FR07R1723116745
Availability:
Available from INIS in electronic form
Submitting Site:
FRN
Size:
20 pages
Announcement Date:
Dec 29, 2007

Citation Formats

Cohen, Y. Some examples of the use of radioactive tracers in pharmacodynamic; Quelques exemples de l'emploi des traceurs radioactifs en pharmacodynamie. France: N. p., 1960. Web.
Cohen, Y. Some examples of the use of radioactive tracers in pharmacodynamic; Quelques exemples de l'emploi des traceurs radioactifs en pharmacodynamie. France.
Cohen, Y. 1960. "Some examples of the use of radioactive tracers in pharmacodynamic; Quelques exemples de l'emploi des traceurs radioactifs en pharmacodynamie." France.
@misc{etde_20967960,
title = {Some examples of the use of radioactive tracers in pharmacodynamic; Quelques exemples de l'emploi des traceurs radioactifs en pharmacodynamie}
author = {Cohen, Y}
abstractNote = {The study of absorption, of distribution in the organism and of the elimination of a medicament has been greatly facilitated by the development of nuclear applications. In effect, the introduction into the molecule of one or several radioactive atoms makes it possible to follow the path and destination of minute quantities of the drug and to thus carry out analyses on the animal within limits of posology close to those of therapeutics. However the qualitative or quantitative methods used have certain limits and they must be compared amongst themselves and with others. Some examples will show : - the importance of the way of administering the drug on the changes in the distribution; - the quite relative selectivity of this latter; - and lastly, the different process involved in the elimination mechanisms. (author) [French] L'etude de l'absorption, de la repartition dans l'organisme et de l'elimination d'un medicament s'est trouvee grandement facilitee par le developpement des applications nucleaires. En effet, l'introduction dans une molecule d'un ou plusieurs atomes radioactifs permet de suivre le sort de quantites infimes de la drogue et de ce fait d'en effectuer l'analyse chez l'animal dans des limites de posologie se rapprochant de celles de la therapeutique. Cependant les methodes employees, qualitatives ou quantitatives, presentent des limites et doivent etre confrontees entre elles et avec d'autres methodes. Quelques exemples mettront en evidence: - l'importance du mode d'administration sur l'evolution de la repartition, - l'electivite toute relative de cette derniere, - et enfin, les modalites diverses des mecanismes d'elimination. (auteur)}
place = {France}
year = {1960}
month = {Jul}
}