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Synthesis and bio-evaluation of nano-hydroxyapatite trapped by {sup 153}Sm

Abstract

After nanoHA was synthesized, {sup 153}Sm-EDTMP-nanoHA and {sup 153}Sm-citrate-nanoHA were prepared and proved stable in vitro. ECT images of New Zealand rabbits injected with {sup 153}Sm-EDTMP-nanoHA had better contrast, skeletal figure visible, liver and spleen clear. The images of {sup 153}Sm-citrate-nanoHA showed a similar results but kidney invisible, which meant {sup 153}Sm-citrate-nanoHA showed a similar results but kidney invisible, which meant {sup 153}Sm-citrate-nanoHA was mainly excreted through liver and gall. {sup 153}Sm-EDTMP-nanoHA's half effective inhibition concentrations to SMMC-7721 and MCF-7 cells were 1.98 g/L and 0.075 g/L respectively and {sup 153}Sm-citrate-nanoHA's were 1.89 g/L and 0.094 g/L proportionally. {sup 153}Sm-EDTMP-nanoHA and {sup 153}Sm-citrate-nanoHA were worthy of a further research because their half effective inhibition concentrations were much lower than ones of the single nanoHA. (authors)
Authors:
Wenzeng, Bing; Shunzhong, Luo; Guanghua, Wen; Shubin, Jiang; Xiaoling, Xiong; Guoping, Liu [1] 
  1. China Academy of Engineering Physics, Mianyang (China). Inst. of Nuclear Physics and Chemistry
Publication Date:
Mar 15, 2006
Product Type:
Technical Report
Report Number:
CNIC-01833; CAEP-0168
Resource Relation:
Other Information: 16 figs., 4 refs
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; APATITES; CHEMICAL PREPARATION; CITRATES; COMPUTERIZED TOMOGRAPHY; CONCENTRATION RATIO; CONTRAST MEDIA; HEPATOMAS; IMAGES; IN VITRO; INHIBITION; KIDNEYS; LABELLING; LIVER; MAMMARY GLANDS; NANOSTRUCTURES; RABBITS; RADIOPHARMACEUTICALS; SAMARIUM 153; SPLEEN
OSTI ID:
20960482
Research Organizations:
Chinese Nuclear Information Centre, Beijing (China)
Country of Origin:
China
Language:
Chinese
Other Identifying Numbers:
Other: ISBN 7-5022-3564-7; TRN: CN0703118111076
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
8 pages
Announcement Date:
Dec 31, 2007

Citation Formats

Wenzeng, Bing, Shunzhong, Luo, Guanghua, Wen, Shubin, Jiang, Xiaoling, Xiong, and Guoping, Liu. Synthesis and bio-evaluation of nano-hydroxyapatite trapped by {sup 153}Sm. China: N. p., 2006. Web.
Wenzeng, Bing, Shunzhong, Luo, Guanghua, Wen, Shubin, Jiang, Xiaoling, Xiong, & Guoping, Liu. Synthesis and bio-evaluation of nano-hydroxyapatite trapped by {sup 153}Sm. China.
Wenzeng, Bing, Shunzhong, Luo, Guanghua, Wen, Shubin, Jiang, Xiaoling, Xiong, and Guoping, Liu. 2006. "Synthesis and bio-evaluation of nano-hydroxyapatite trapped by {sup 153}Sm." China.
@misc{etde_20960482,
title = {Synthesis and bio-evaluation of nano-hydroxyapatite trapped by {sup 153}Sm}
author = {Wenzeng, Bing, Shunzhong, Luo, Guanghua, Wen, Shubin, Jiang, Xiaoling, Xiong, and Guoping, Liu}
abstractNote = {After nanoHA was synthesized, {sup 153}Sm-EDTMP-nanoHA and {sup 153}Sm-citrate-nanoHA were prepared and proved stable in vitro. ECT images of New Zealand rabbits injected with {sup 153}Sm-EDTMP-nanoHA had better contrast, skeletal figure visible, liver and spleen clear. The images of {sup 153}Sm-citrate-nanoHA showed a similar results but kidney invisible, which meant {sup 153}Sm-citrate-nanoHA showed a similar results but kidney invisible, which meant {sup 153}Sm-citrate-nanoHA was mainly excreted through liver and gall. {sup 153}Sm-EDTMP-nanoHA's half effective inhibition concentrations to SMMC-7721 and MCF-7 cells were 1.98 g/L and 0.075 g/L respectively and {sup 153}Sm-citrate-nanoHA's were 1.89 g/L and 0.094 g/L proportionally. {sup 153}Sm-EDTMP-nanoHA and {sup 153}Sm-citrate-nanoHA were worthy of a further research because their half effective inhibition concentrations were much lower than ones of the single nanoHA. (authors)}
place = {China}
year = {2006}
month = {Mar}
}