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Role of Serum Insulin-Like Growth Factor I and Ghrelin in Chronic Liver Diseases

Journal Article:

Abstract

Chronic liver disease (CLD) is characterized by numerous metabolic alterations resulting in the clinical picture of malnutrition or even cachexia and contributing to complications such as hepatic encephalopathy and ascetics. In view of these alternations, this study was conducted to investigate the role of serum insulin-like growth factor-I (IGF-I) and ghrelin in CLD with or without cirrhosis and evaluate their relationships with liver functions and clinical complications. Serum IGF-I levels were very highly significantly lowered (P< 0.0001) in hepatitis C virus (HCV) patients and in hepatocellular carcinoma (HCC) patients than in the control group. However, serum ghrelin levels were significantly elevated in HCV and in HCC patients when compared with controls (P< 0.05). IGF-I significantly decreased with every stage of cirrhosis according to Child-Pugh classification. In contrast, serum ghrelin levels were significantly elevated in Child C liver cirrhosis compared to non cirrhotic patients (Child A and Child B cirrhosis). IGF-I levels inversely correlated with prothrombin time (PT.), total bilirubin and positively correlated with serum albumin. While serum ghrelin correlated with clinical complications of CLD. No correlations were found between IGF-I and ghrelin in all studied groups, however, both inversely correlated with a-feto protein (AFP) in HCC patients. We conclude that  More>>
Authors:
EI-Nashar, N A [1] 
  1. Health Radiation Research Dept., National Centre for Radiation Research alld Technology (NCRRT), P.G: 29 Nasr City, Cairo (Egypt)
Publication Date:
Jul 01, 2008
Product Type:
Journal Article
Resource Relation:
Journal Name: Egyptian Journal of Radiation Sciences and Applications; Journal Volume: 21; Journal Issue: 1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ALBUMINS; BILIRUBIN; BLOOD SERUM; CARCINOMAS; CHILDREN; CHRONIC EXPOSURE; CLINICAL TRIALS; GROWTH FACTORS; HEPATITIS; INSULIN; LIVER; LIVER CIRRHOSIS; METABOLIC DISEASES; NUTRITIONAL DEFICIENCY; PATIENTS; PROTEINS
OSTI ID:
20957130
Country of Origin:
Egypt
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1110-0303; EJRAES; TRN: EG0700669107634
Submitting Site:
INIS
Size:
page(s) 187-208
Announcement Date:
Dec 29, 2007

Journal Article:

Citation Formats

EI-Nashar, N A. Role of Serum Insulin-Like Growth Factor I and Ghrelin in Chronic Liver Diseases. Egypt: N. p., 2008. Web.
EI-Nashar, N A. Role of Serum Insulin-Like Growth Factor I and Ghrelin in Chronic Liver Diseases. Egypt.
EI-Nashar, N A. 2008. "Role of Serum Insulin-Like Growth Factor I and Ghrelin in Chronic Liver Diseases." Egypt.
@misc{etde_20957130,
title = {Role of Serum Insulin-Like Growth Factor I and Ghrelin in Chronic Liver Diseases}
author = {EI-Nashar, N A}
abstractNote = {Chronic liver disease (CLD) is characterized by numerous metabolic alterations resulting in the clinical picture of malnutrition or even cachexia and contributing to complications such as hepatic encephalopathy and ascetics. In view of these alternations, this study was conducted to investigate the role of serum insulin-like growth factor-I (IGF-I) and ghrelin in CLD with or without cirrhosis and evaluate their relationships with liver functions and clinical complications. Serum IGF-I levels were very highly significantly lowered (P< 0.0001) in hepatitis C virus (HCV) patients and in hepatocellular carcinoma (HCC) patients than in the control group. However, serum ghrelin levels were significantly elevated in HCV and in HCC patients when compared with controls (P< 0.05). IGF-I significantly decreased with every stage of cirrhosis according to Child-Pugh classification. In contrast, serum ghrelin levels were significantly elevated in Child C liver cirrhosis compared to non cirrhotic patients (Child A and Child B cirrhosis). IGF-I levels inversely correlated with prothrombin time (PT.), total bilirubin and positively correlated with serum albumin. While serum ghrelin correlated with clinical complications of CLD. No correlations were found between IGF-I and ghrelin in all studied groups, however, both inversely correlated with a-feto protein (AFP) in HCC patients. We conclude that IGF-I.and ghrelin can predict the diagnosis and prognosis of patients with severe CLD as they have potential relationships with hepatic failure and HCC.}
journal = {Egyptian Journal of Radiation Sciences and Applications}
issue = {1}
volume = {21}
place = {Egypt}
year = {2008}
month = {Jul}
}