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Characterization of potential ionizing radiation biomarkers by a proteomic approach

Abstract

Radio-induced lesions are tissue specific, hardly predictable, and can arise months or years later. The finding of prognostic bio-markers is of fundamental relevance for the settlement of therapeutic or preventive strategies. Using two-dimensional gel electrophoresis and mass spectrometry, a proteomic study was applied to look for differentially expressed proteins, i.e. potential bio-markers candidates, in mouse serums after a local irradiation of the dorsal skin. Our results clearly indicated that serum protein content was dynamically modified after a local skin irradiation. A set of specific proteins were early down- or up-regulated and could turn out to be good candidates as diagnostic or prognostic bio-markers. (author)
Authors:
Guipaud, O; Vereycken-Holler, V; Benderitter, M; [1]  Royer, N; Vinh, J [2] 
  1. Institut de Radioprotection et de Surete Nucleaire, Lab. de Radiopathologie, 92 - Fontenay aux Roses (France)
  2. Ecole Superieure de Physique et de Chimie Industrielles, 75 - Paris (France)
Publication Date:
Jul 01, 2006
Product Type:
Conference
Report Number:
INIS-FR-6732
Resource Relation:
Conference: Second European IRPA congress on radiation protection - Radiation protection: from knowledge to action, Paris (France), 15-19 May 2006
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BIOLOGICAL MARKERS; BIOLOGICAL RADIATION EFFECTS; DELAYED RADIATION EFFECTS; OCCUPATIONAL EXPOSURE; PROTEINS; RADIATION ACCIDENTS; RADIATION INJURIES; RADIOINDUCTION; RADIOTHERAPY; SKIN
OSTI ID:
20953985
Research Organizations:
Societe Francaise de Radioprotection - SFRP, BP72, 92263 Fontenay-aux-Roses Cedex (France)
Country of Origin:
France
Language:
English
Other Identifying Numbers:
TRN: FR0700872105301
Availability:
Available from INIS in electronic form
Submitting Site:
FRN
Size:
9 pages
Announcement Date:
Dec 27, 2007

Citation Formats

Guipaud, O, Vereycken-Holler, V, Benderitter, M, Royer, N, and Vinh, J. Characterization of potential ionizing radiation biomarkers by a proteomic approach. France: N. p., 2006. Web.
Guipaud, O, Vereycken-Holler, V, Benderitter, M, Royer, N, & Vinh, J. Characterization of potential ionizing radiation biomarkers by a proteomic approach. France.
Guipaud, O, Vereycken-Holler, V, Benderitter, M, Royer, N, and Vinh, J. 2006. "Characterization of potential ionizing radiation biomarkers by a proteomic approach." France.
@misc{etde_20953985,
title = {Characterization of potential ionizing radiation biomarkers by a proteomic approach}
author = {Guipaud, O, Vereycken-Holler, V, Benderitter, M, Royer, N, and Vinh, J}
abstractNote = {Radio-induced lesions are tissue specific, hardly predictable, and can arise months or years later. The finding of prognostic bio-markers is of fundamental relevance for the settlement of therapeutic or preventive strategies. Using two-dimensional gel electrophoresis and mass spectrometry, a proteomic study was applied to look for differentially expressed proteins, i.e. potential bio-markers candidates, in mouse serums after a local irradiation of the dorsal skin. Our results clearly indicated that serum protein content was dynamically modified after a local skin irradiation. A set of specific proteins were early down- or up-regulated and could turn out to be good candidates as diagnostic or prognostic bio-markers. (author)}
place = {France}
year = {2006}
month = {Jul}
}