Abstract
Investigations of radioprotective effects of Deltiazem (as one of the commonly used calcium channel blockers, which is used in the treatment of acute and chronic angina and spasmo angina, in addition to the treatment of different types of essential hypertension) has been carried on Saccharomyces Cerevisiae cells. Cells cultures of the most famous yeast Saccharomyces Cerevisiae (bakers yeast) were irradiated with different doses of gamma rays. Results revealed that the necessary dose of gamma rays that leads to 10% of survived cellular population (D10 value) was about 256 Gy. This irradiation dose was used then in all irradiation experiments on culture of S. Cerevisiae cells in which different concentrations of Deltiazem (55, 110, 165 mg/Kg medium) were added before and after irradiation in order to study the radio protective effect of Deltiazem. Results showed that Deltiazem enhances survival percentage of irradiated S. Cerevisiae cultures in a concentration dependent manner. This study confirmed our previous works, which had demonstrated that Deltiazem protects lethally and supralethally irradiated rats, and enhances survival of pre-irradiated Deltiazem treated animals.(author)
Alya, G;
Shamma, M;
Sharabi, N
[1]
- Atomic Energy Commission, Damascus (Syrian Arab Republic), Dept. of Molecular Biology and Biotechnology
Citation Formats
Alya, G, Shamma, M, and Sharabi, N.
Radio protective effects of calcium channel blockers (Deltiazem) on survival of Saccharomyces cerevisiae cells irradiated with different doses of gamma rays.
Syrian Arab Republic: N. p.,
2007.
Web.
Alya, G, Shamma, M, & Sharabi, N.
Radio protective effects of calcium channel blockers (Deltiazem) on survival of Saccharomyces cerevisiae cells irradiated with different doses of gamma rays.
Syrian Arab Republic.
Alya, G, Shamma, M, and Sharabi, N.
2007.
"Radio protective effects of calcium channel blockers (Deltiazem) on survival of Saccharomyces cerevisiae cells irradiated with different doses of gamma rays."
Syrian Arab Republic.
@misc{etde_20946616,
title = {Radio protective effects of calcium channel blockers (Deltiazem) on survival of Saccharomyces cerevisiae cells irradiated with different doses of gamma rays}
author = {Alya, G, Shamma, M, and Sharabi, N}
abstractNote = {Investigations of radioprotective effects of Deltiazem (as one of the commonly used calcium channel blockers, which is used in the treatment of acute and chronic angina and spasmo angina, in addition to the treatment of different types of essential hypertension) has been carried on Saccharomyces Cerevisiae cells. Cells cultures of the most famous yeast Saccharomyces Cerevisiae (bakers yeast) were irradiated with different doses of gamma rays. Results revealed that the necessary dose of gamma rays that leads to 10% of survived cellular population (D10 value) was about 256 Gy. This irradiation dose was used then in all irradiation experiments on culture of S. Cerevisiae cells in which different concentrations of Deltiazem (55, 110, 165 mg/Kg medium) were added before and after irradiation in order to study the radio protective effect of Deltiazem. Results showed that Deltiazem enhances survival percentage of irradiated S. Cerevisiae cultures in a concentration dependent manner. This study confirmed our previous works, which had demonstrated that Deltiazem protects lethally and supralethally irradiated rats, and enhances survival of pre-irradiated Deltiazem treated animals.(author)}
place = {Syrian Arab Republic}
year = {2007}
month = {Mar}
}
title = {Radio protective effects of calcium channel blockers (Deltiazem) on survival of Saccharomyces cerevisiae cells irradiated with different doses of gamma rays}
author = {Alya, G, Shamma, M, and Sharabi, N}
abstractNote = {Investigations of radioprotective effects of Deltiazem (as one of the commonly used calcium channel blockers, which is used in the treatment of acute and chronic angina and spasmo angina, in addition to the treatment of different types of essential hypertension) has been carried on Saccharomyces Cerevisiae cells. Cells cultures of the most famous yeast Saccharomyces Cerevisiae (bakers yeast) were irradiated with different doses of gamma rays. Results revealed that the necessary dose of gamma rays that leads to 10% of survived cellular population (D10 value) was about 256 Gy. This irradiation dose was used then in all irradiation experiments on culture of S. Cerevisiae cells in which different concentrations of Deltiazem (55, 110, 165 mg/Kg medium) were added before and after irradiation in order to study the radio protective effect of Deltiazem. Results showed that Deltiazem enhances survival percentage of irradiated S. Cerevisiae cultures in a concentration dependent manner. This study confirmed our previous works, which had demonstrated that Deltiazem protects lethally and supralethally irradiated rats, and enhances survival of pre-irradiated Deltiazem treated animals.(author)}
place = {Syrian Arab Republic}
year = {2007}
month = {Mar}
}