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Study of a case of essential hypoproteinaemia using the isotopes {sup 131}I and {sup 15}N; Etude a l'aide des isotopes {sup 131}I et {sup 15}N d'un cas d'hypoproteinemie essentielle

Abstract

Hypoproteinaemia both human and experimental has been studied with the help of nuclear labelling. A comparative study has been made of the fate of serum proteins labelled by an endogenous path after administration of nitrogen-15 glycine and also of serum albumin labelled by exogenous path using iodine-131. We have determined the biological period of the serum albumin and serum globulins and also the magnitude of the vascular and extravascular pools of serum albumin. In this way it has been possible to measure the speed of replacement of plasma proteins. A presentation of results taken from both clinical observation and experiment leads to a discussion on the pathogenic mechanism of hypoproteinaemia. (author) [French] Les hypoproteinemies humaine et experimentale ont ete explorees a l'aide d'indicateurs nucleaires. Une etude comparative du devenir des proteines seriques marquees par voie endogene, apres administration de glycocolle-{sup 15}N et de l'albumine serique marquee par voie exogene a l'iode-131 a ete realisee. On a determine la periode biologique de la serumalbumine et des globulines seriques ainsi que la grandeur des 'pools' vasculaire et extravasculaire de la serumalbumine. Il a ete ainsi possible d'evaluer la vitesse de renouvellement des proteines plasmatiques. La confrontation des resultats tires de l'observation clinique  More>>
Authors:
Dubert, A; Coursaget, J; Fallot, P; Royer, P; [1]  Hopital des Enfants Malades, 75 - Paris (France)]
  1. Commissariat a l'Energie Atomique, Saclay (France).Centre d'Etudes Nucleaires
Publication Date:
Jul 01, 1959
Product Type:
Technical Report
Report Number:
CEA-R-1216
Resource Relation:
Other Information: 14 refs
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ALBUMINS; BIOLOGICAL PATHWAYS; BIOSYNTHESIS; BLOOD SERUM; BLOOD-PLASMA CLEARANCE; CLINICAL TRIALS; GLOBULINS; GLYCINE; IODINE 131; LABELLED POOL TECHNIQUES; LABELLING; METABOLIC DISEASES; METABOLISM; NITROGEN 15; PATHOGENESIS
OSTI ID:
20940735
Research Organizations:
CEA Saclay, 91 - Gif-sur-Yvette (France)
Country of Origin:
France
Language:
French
Other Identifying Numbers:
TRN: FR07R1216094213
Availability:
Available from INIS in electronic form
Submitting Site:
FRN
Size:
11 pages
Announcement Date:
Nov 22, 2007

Citation Formats

Dubert, A, Coursaget, J, Fallot, P, Royer, P, and Hopital des Enfants Malades, 75 - Paris (France)]. Study of a case of essential hypoproteinaemia using the isotopes {sup 131}I and {sup 15}N; Etude a l'aide des isotopes {sup 131}I et {sup 15}N d'un cas d'hypoproteinemie essentielle. France: N. p., 1959. Web.
Dubert, A, Coursaget, J, Fallot, P, Royer, P, & Hopital des Enfants Malades, 75 - Paris (France)]. Study of a case of essential hypoproteinaemia using the isotopes {sup 131}I and {sup 15}N; Etude a l'aide des isotopes {sup 131}I et {sup 15}N d'un cas d'hypoproteinemie essentielle. France.
Dubert, A, Coursaget, J, Fallot, P, Royer, P, and Hopital des Enfants Malades, 75 - Paris (France)]. 1959. "Study of a case of essential hypoproteinaemia using the isotopes {sup 131}I and {sup 15}N; Etude a l'aide des isotopes {sup 131}I et {sup 15}N d'un cas d'hypoproteinemie essentielle." France.
@misc{etde_20940735,
title = {Study of a case of essential hypoproteinaemia using the isotopes {sup 131}I and {sup 15}N; Etude a l'aide des isotopes {sup 131}I et {sup 15}N d'un cas d'hypoproteinemie essentielle}
author = {Dubert, A, Coursaget, J, Fallot, P, Royer, P, and Hopital des Enfants Malades, 75 - Paris (France)]}
abstractNote = {Hypoproteinaemia both human and experimental has been studied with the help of nuclear labelling. A comparative study has been made of the fate of serum proteins labelled by an endogenous path after administration of nitrogen-15 glycine and also of serum albumin labelled by exogenous path using iodine-131. We have determined the biological period of the serum albumin and serum globulins and also the magnitude of the vascular and extravascular pools of serum albumin. In this way it has been possible to measure the speed of replacement of plasma proteins. A presentation of results taken from both clinical observation and experiment leads to a discussion on the pathogenic mechanism of hypoproteinaemia. (author) [French] Les hypoproteinemies humaine et experimentale ont ete explorees a l'aide d'indicateurs nucleaires. Une etude comparative du devenir des proteines seriques marquees par voie endogene, apres administration de glycocolle-{sup 15}N et de l'albumine serique marquee par voie exogene a l'iode-131 a ete realisee. On a determine la periode biologique de la serumalbumine et des globulines seriques ainsi que la grandeur des 'pools' vasculaire et extravasculaire de la serumalbumine. Il a ete ainsi possible d'evaluer la vitesse de renouvellement des proteines plasmatiques. La confrontation des resultats tires de l'observation clinique et de l'experimentation conduit a une discussion sur le mecanisme pathogenique de l'hypoproteinemie. (auteur)}
place = {France}
year = {1959}
month = {Jul}
}