Abstract
The experiments consisted in feeding daily to rats the same mass of radioactive cholesterol, over variable time intervals. From the evolution of the specific radioactivity of cholesterol carbon-14 in the organs as a function of time, information relative to the transport of cholesterol in the organism may be obtained. 1) The cholesterol space, defined as the group of molecules capable of being transferred from the organs into the serum and vice versa, represents at the most 50 per cent of the total cholesterol of the adult rat. 2) The incessant interchange between the tissual and the serum cholesterol renews entirely or for the most part the cholesterol molecules contained in the following organs: spleen, heart, adipose tissue, suprarenal glands, lungs, bone marrow, liver, erythrocytes. For a second group of organs: skin, testicles, kidneys, colon, bones, muscles, only a fraction of their cholesterol is renewable by this process. No transfer can be detected at the level of the brain. 3) The relative speeds of the various means of appearance (absorption, synthesis) and disappearance (excretion, transformation) of the cholesterol from its space are such that a stationary isotopic state is established around the eighth day, when the animal absorbs 5 milligrams of
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Chevallier, F
[1]
- Commissariat a l'Energie Atomique, Saclay (France).Centre d'Etudes Nucleaires
Citation Formats
Chevallier, F.
The cholesterol space of the rat; L'espace cholesterol du rat.
France: N. p.,
1959.
Web.
Chevallier, F.
The cholesterol space of the rat; L'espace cholesterol du rat.
France.
Chevallier, F.
1959.
"The cholesterol space of the rat; L'espace cholesterol du rat."
France.
@misc{etde_20940729,
title = {The cholesterol space of the rat; L'espace cholesterol du rat}
author = {Chevallier, F}
abstractNote = {The experiments consisted in feeding daily to rats the same mass of radioactive cholesterol, over variable time intervals. From the evolution of the specific radioactivity of cholesterol carbon-14 in the organs as a function of time, information relative to the transport of cholesterol in the organism may be obtained. 1) The cholesterol space, defined as the group of molecules capable of being transferred from the organs into the serum and vice versa, represents at the most 50 per cent of the total cholesterol of the adult rat. 2) The incessant interchange between the tissual and the serum cholesterol renews entirely or for the most part the cholesterol molecules contained in the following organs: spleen, heart, adipose tissue, suprarenal glands, lungs, bone marrow, liver, erythrocytes. For a second group of organs: skin, testicles, kidneys, colon, bones, muscles, only a fraction of their cholesterol is renewable by this process. No transfer can be detected at the level of the brain. 3) The relative speeds of the various means of appearance (absorption, synthesis) and disappearance (excretion, transformation) of the cholesterol from its space are such that a stationary isotopic state is established around the eighth day, when the animal absorbs 5 milligrams of radioactive cholesterol daily. (author) [French] Les experiences ont consiste a faire ingerer quotidiennement une meme masse de cholesterol radioactif a des rats, durant des laps de temps variables. L'evolution de la radioactivite specifique du carbone-14 du cholesterol des organes en fonction du temps permet d'obtenir des renseignements relatifs au transport du cholesterol dans l'organisme. 1) L'espace cholesterol defini comme l'ensemble des molecules susceptibles d'etre transferees des organes dans le serum, et vice-versa, represente au plus 50 pour cent du cholesterol total du rat adulte. 2) Le va et vient incessant entre le cholesterol tissulaire et le cholesterol serique renouvelle en totalite ou en majeure partie les molecules de cholesterol contenues dans les organes suivants: rate, coeur, tissu adipeux, surrenales, poumons, moelle osseuse, foie, hematies. Pour un deuxieme groupe d'organes: peau, testicules, reins, colon, os, muscles, seule une fraction de leur cholesterol est renouvelable par ce processus. Aucun transfert n'est decelable au niveau du cerveau. 3) Les vitesses relatives des differents modes d'appartition (absorption, synthese) et de disparition (excretion, transformation) du cholesterol de son espace sont telles qu'un etat stationnaire isotopique s'y etablit vers le huitieme jour, lorsque l'animal ingere quotidiennement 5 milligrammes de cholesterol radioactif. (auteur)}
place = {France}
year = {1959}
month = {Jul}
}
title = {The cholesterol space of the rat; L'espace cholesterol du rat}
author = {Chevallier, F}
abstractNote = {The experiments consisted in feeding daily to rats the same mass of radioactive cholesterol, over variable time intervals. From the evolution of the specific radioactivity of cholesterol carbon-14 in the organs as a function of time, information relative to the transport of cholesterol in the organism may be obtained. 1) The cholesterol space, defined as the group of molecules capable of being transferred from the organs into the serum and vice versa, represents at the most 50 per cent of the total cholesterol of the adult rat. 2) The incessant interchange between the tissual and the serum cholesterol renews entirely or for the most part the cholesterol molecules contained in the following organs: spleen, heart, adipose tissue, suprarenal glands, lungs, bone marrow, liver, erythrocytes. For a second group of organs: skin, testicles, kidneys, colon, bones, muscles, only a fraction of their cholesterol is renewable by this process. No transfer can be detected at the level of the brain. 3) The relative speeds of the various means of appearance (absorption, synthesis) and disappearance (excretion, transformation) of the cholesterol from its space are such that a stationary isotopic state is established around the eighth day, when the animal absorbs 5 milligrams of radioactive cholesterol daily. (author) [French] Les experiences ont consiste a faire ingerer quotidiennement une meme masse de cholesterol radioactif a des rats, durant des laps de temps variables. L'evolution de la radioactivite specifique du carbone-14 du cholesterol des organes en fonction du temps permet d'obtenir des renseignements relatifs au transport du cholesterol dans l'organisme. 1) L'espace cholesterol defini comme l'ensemble des molecules susceptibles d'etre transferees des organes dans le serum, et vice-versa, represente au plus 50 pour cent du cholesterol total du rat adulte. 2) Le va et vient incessant entre le cholesterol tissulaire et le cholesterol serique renouvelle en totalite ou en majeure partie les molecules de cholesterol contenues dans les organes suivants: rate, coeur, tissu adipeux, surrenales, poumons, moelle osseuse, foie, hematies. Pour un deuxieme groupe d'organes: peau, testicules, reins, colon, os, muscles, seule une fraction de leur cholesterol est renouvelable par ce processus. Aucun transfert n'est decelable au niveau du cerveau. 3) Les vitesses relatives des differents modes d'appartition (absorption, synthese) et de disparition (excretion, transformation) du cholesterol de son espace sont telles qu'un etat stationnaire isotopique s'y etablit vers le huitieme jour, lorsque l'animal ingere quotidiennement 5 milligrammes de cholesterol radioactif. (auteur)}
place = {France}
year = {1959}
month = {Jul}
}