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Modeling the systemic retention of beryllium in rat. Extrapolation to human; Modelizacion de la retencion sistemica del berilio en la rata. Extrapolacion al Hombre

Abstract

In this work, we analyzed different approaches, assayed in order to numerically describe the systemic behaviour of Beryllium. The experimental results used in this work, were previously obtained by Furchner et al. (1973), using Sprague-Dawley rats, and others animal species. Furchner's work includes the obtained model for whole body retention in rats, but not for each target organ. In this work we present the results obtained by modeling the kinetic behaviour of Beryllium in several target organs. The results of this kind of models were used in order to establish correlations among the estimated kinetic constants. The parameters of the model were extrapolated to humans and, finally, compared with others previously published. (Author) 12 refs.
Publication Date:
Jul 01, 1994
Product Type:
Technical Report
Report Number:
CIEMAT-747
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; MICE; BERYLLIUM; RADIONUCLIDE KINETICS; CONCENTRATION RATIO; BIOLOGICAL MODELS
OSTI ID:
20930082
Research Organizations:
Centro de Investigaciones Energeticas Medioambientales y Tecnologicas (CIEMAT), Madrid (Spain)
Country of Origin:
Spain
Language:
Spanish
Other Identifying Numbers:
TRN: ES07B0448
Availability:
Commercial reproduction prohibited; OSTI as DE20930082
Submitting Site:
SPN
Size:
36 pages
Announcement Date:
Sep 27, 2007

Citation Formats

Montero Prieto, M, and Vidania Munoz, R de. Modeling the systemic retention of beryllium in rat. Extrapolation to human; Modelizacion de la retencion sistemica del berilio en la rata. Extrapolacion al Hombre. Spain: N. p., 1994. Web.
Montero Prieto, M, & Vidania Munoz, R de. Modeling the systemic retention of beryllium in rat. Extrapolation to human; Modelizacion de la retencion sistemica del berilio en la rata. Extrapolacion al Hombre. Spain.
Montero Prieto, M, and Vidania Munoz, R de. 1994. "Modeling the systemic retention of beryllium in rat. Extrapolation to human; Modelizacion de la retencion sistemica del berilio en la rata. Extrapolacion al Hombre." Spain.
@misc{etde_20930082,
title = {Modeling the systemic retention of beryllium in rat. Extrapolation to human; Modelizacion de la retencion sistemica del berilio en la rata. Extrapolacion al Hombre}
author = {Montero Prieto, M, and Vidania Munoz, R de}
abstractNote = {In this work, we analyzed different approaches, assayed in order to numerically describe the systemic behaviour of Beryllium. The experimental results used in this work, were previously obtained by Furchner et al. (1973), using Sprague-Dawley rats, and others animal species. Furchner's work includes the obtained model for whole body retention in rats, but not for each target organ. In this work we present the results obtained by modeling the kinetic behaviour of Beryllium in several target organs. The results of this kind of models were used in order to establish correlations among the estimated kinetic constants. The parameters of the model were extrapolated to humans and, finally, compared with others previously published. (Author) 12 refs.}
place = {Spain}
year = {1994}
month = {Jul}
}