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Liver and water metabolism; Foie et metabolisme de l'eau

Abstract

The causes for the disturbance of hydro-electrolytic equilibrium observed in cirrhosis patients are far from clear. Studies on the static distribution of liquid in the organism and also on anomalies in the distribution of deuterium oxide and tritiated water provide no direct explanation of the nature of the water retaining mechanism. At the period when the illness is established, endocrine factors and electrolytic perturbations contribute to maintaining or increasing oliguresis, but they cannot be held solely responsible in the initial stages of evolution. An explanation of the ascites should therefore be looked for in a non-functioning of the polygonal or Kupffer cells. The hypothesis of an insufficient rejection of water outside the lymph spaces of the liver during cirrhosis is put forward, but the experimental demonstration of such a phenomenon proves very difficult. (author) [French] Les causes du desequilibre hydroelectrolytique observe chez les malades cirrhotiques sont loin d'etre elucidees. Les etudes de la repartition du liquide de l'organisme ainsi que celles des anomalies de la distribution de l'oxyde de deuterium et de l'eau tritiee n'apportent aucune explication directe sur la nature du mecanisme de la retention de l'eau. A la periode d'etat de la maladie, les facteurs endocriniens et les  More>>
Authors:
Fallot, P; [1]  Faculte des Sciences de Grenoble, 38 (France)]
  1. Commissariat a l'Energie Atomique, Saclay (France). Centre d'Etudes Nucleaires
Publication Date:
Jul 01, 1959
Product Type:
Technical Report
Report Number:
CEA-R-1169
Resource Relation:
Conference: International conference on the biliary function, Congres international sur la fonction biliaire, Vittel (France), 26-29 Jun 1958; Other Information: 76 refs
Subject:
60 APPLIED LIFE SCIENCES; ANIMAL TISSUES; ASCITES; BIOLOGICAL LOCALIZATION; BLOOD PLASMA; CAPILLARIES; CORRELATIONS; EXTRACELLULAR SPACE; INTRAPERITONEAL INJECTION; INTRAVENOUS INJECTION; LIVER CIRRHOSIS; METABOLISM; PATHOGENESIS; PERMEABILITY; RETENTION; TIME DEPENDENCE; TISSUE DISTRIBUTION; TRITIUM OXIDES; WATER
OSTI ID:
20912800
Research Organizations:
CEA Saclay, 91 - Gif-sur-Yvette (France); Centre Nationale de la Recherche Scientifique, 75 - Paris (France)
Country of Origin:
France
Language:
French
Other Identifying Numbers:
TRN: FR07R1169073976
Availability:
Available from INIS in electronic form
Submitting Site:
FRN
Size:
16 pages
Announcement Date:
Sep 22, 2007

Citation Formats

Fallot, P, and Faculte des Sciences de Grenoble, 38 (France)]. Liver and water metabolism; Foie et metabolisme de l'eau. France: N. p., 1959. Web.
Fallot, P, & Faculte des Sciences de Grenoble, 38 (France)]. Liver and water metabolism; Foie et metabolisme de l'eau. France.
Fallot, P, and Faculte des Sciences de Grenoble, 38 (France)]. 1959. "Liver and water metabolism; Foie et metabolisme de l'eau." France.
@misc{etde_20912800,
title = {Liver and water metabolism; Foie et metabolisme de l'eau}
author = {Fallot, P, and Faculte des Sciences de Grenoble, 38 (France)]}
abstractNote = {The causes for the disturbance of hydro-electrolytic equilibrium observed in cirrhosis patients are far from clear. Studies on the static distribution of liquid in the organism and also on anomalies in the distribution of deuterium oxide and tritiated water provide no direct explanation of the nature of the water retaining mechanism. At the period when the illness is established, endocrine factors and electrolytic perturbations contribute to maintaining or increasing oliguresis, but they cannot be held solely responsible in the initial stages of evolution. An explanation of the ascites should therefore be looked for in a non-functioning of the polygonal or Kupffer cells. The hypothesis of an insufficient rejection of water outside the lymph spaces of the liver during cirrhosis is put forward, but the experimental demonstration of such a phenomenon proves very difficult. (author) [French] Les causes du desequilibre hydroelectrolytique observe chez les malades cirrhotiques sont loin d'etre elucidees. Les etudes de la repartition du liquide de l'organisme ainsi que celles des anomalies de la distribution de l'oxyde de deuterium et de l'eau tritiee n'apportent aucune explication directe sur la nature du mecanisme de la retention de l'eau. A la periode d'etat de la maladie, les facteurs endocriniens et les perturbations electrolytiques contribuent a entretenir ou a accroitre l'oligurie mais ils ne peuvent etre seuls invoques lors des stades initiaux de l'evolution. Il faudrait donc rechercher dans un dysfonctionnement des cellules polygonales ou kupfferiennes l'explication de l'ascite. L'hypothese d'une insuffisance du rejet de l'eau hors des espaces lymphatiques du foie au cours de la cirrhose est evoquee mais la demonstration d'un tel phenomene s'avere tres difficile sur le plan experimental. (auteur)}
place = {France}
year = {1959}
month = {Jul}
}