A safeguards symposium has traditionally been organized by the Safeguards Department approximately every four years. The 2006 symposium addresses challenges to IAEA safeguards that have emerged or grown more serious since 2001. The increase in size and flexibility of uranium enrichment plants, for instance, and the spread of enrichment technology to a wider circle of States, pose challenges to traditional safeguards approaches. The procurement and supply networks discovered in 2004, dealing in sensitive nuclear technology and information, have serious implications for the future effectiveness of IAEA safeguards. The symposium will provide an opportunity for the IAEA and Member States to discuss options for dealing constructively with trade in sensitive nuclear technology. Reflecting developments since 2001, the 2006 symposium will focus on current challenges to the safeguards system, improving collection and analysis of safeguards information (analysis, processing tools, satellite imagery), advances in safeguards techniques and technology (future technology, neutron techniques, spent fuel verification, reprocessing, environmental sampling, containment and surveillance), further strengthening safeguards practices and approaches (safeguards approaches, integrated safeguards, R/SSAC, destructive analysis, non-destructive analysis, enrichment, reprocessing, spent fuel transfer) and future challenges. This publication contains 183 extended synopses, each of them was indexed separately.