The School on High-Dimensional Manifold Topology took place at the Abdus Salam ICTP, Trieste from 21 May 2001 to 8 June 2001. The focus of the school was on the classification of manifolds and related aspects of K-theory, geometry, and operator theory. The topics covered included: surgery theory, algebraic K- and L-theory, controlled topology, homology manifolds, exotic aspherical manifolds, homeomorphism and diffeomorphism groups, and scalar curvature. The school consisted of 2 weeks of lecture courses and one week of conference. Thwo-part lecture notes volume contains the notes of most of the lecture courses.