You need JavaScript to view this

Cytotoxic and genotoxic effects caused by {sup 153} Sm-EDTMP, combined with BrdU a thymidine analog; Efecto citotoxico y genotoxico causado por {sup 153} Sm-EDTMP, combinado con BrdU un analogo de timidina

Abstract

The ablation of the bone marrow previous to the transplant by means of radiation and chemical antineoplastics its affect indiscriminately to the healthy tissues and in particular those that are in proliferation. The objective of this work is to determine the effect of the incorporation from the BrdU to the DNA on the genotoxicity and cytotoxicity of the cells of the bone marrow caused by the radiopharmaceutical {sup 153}Sm-EDTMP. The genotoxicity was determined by the rate of erythrocytes polychromatic micro nucleates (EPC-MN) and the cytotoxicity by the frequency of EPC. Both parameters determined in peripheral blood after the BrdU administration and {sup 153}Sm-EDTMP. The combination of the BrdU and r1 radiopharmaceutical produced a bigger cytotoxicity that the radiation and the BrdU alone; on the other hand it produced a reduction of the EPC-MN produced by the radiation, suggesting that the cytotoxicity didn't allow the expression of the genotoxicity. (Author)
Authors:
Morales A, E; Ferro F, G; Morales R, P [1] 
  1. ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)
Publication Date:
Jul 01, 2006
Product Type:
Conference
Report Number:
INIS-MX-2253
Resource Relation:
Conference: 16. ININ-SUTIN Technical and Scientific Congress, Salazar, Estado de Mexico (Mexico), 6-7 Dec 2006
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BONE MARROW; BUDR; DIAGRAMS; DNA; IODODEOXYURIDINE; MICE; MONTE CARLO METHOD; NEOPLASMS; RADIATION DOSES; RADIOPHARMACEUTICALS; SAMARIUM 153; THYMIDINE; TOXICITY
OSTI ID:
20899211
Research Organizations:
Instituto Nacional de Investigaciones Nucleares. Sindicato Unico de Trabajadores de la Industria Nuclear (Mexico)
Country of Origin:
Mexico
Language:
Spanish
Other Identifying Numbers:
TRN: MX0700286061408
Availability:
Available from INIS in electronic form
Submitting Site:
MXN
Size:
7 pages
Announcement Date:
Aug 28, 2007

Citation Formats

Morales A, E, Ferro F, G, and Morales R, P. Cytotoxic and genotoxic effects caused by {sup 153} Sm-EDTMP, combined with BrdU a thymidine analog; Efecto citotoxico y genotoxico causado por {sup 153} Sm-EDTMP, combinado con BrdU un analogo de timidina. Mexico: N. p., 2006. Web.
Morales A, E, Ferro F, G, & Morales R, P. Cytotoxic and genotoxic effects caused by {sup 153} Sm-EDTMP, combined with BrdU a thymidine analog; Efecto citotoxico y genotoxico causado por {sup 153} Sm-EDTMP, combinado con BrdU un analogo de timidina. Mexico.
Morales A, E, Ferro F, G, and Morales R, P. 2006. "Cytotoxic and genotoxic effects caused by {sup 153} Sm-EDTMP, combined with BrdU a thymidine analog; Efecto citotoxico y genotoxico causado por {sup 153} Sm-EDTMP, combinado con BrdU un analogo de timidina." Mexico.
@misc{etde_20899211,
title = {Cytotoxic and genotoxic effects caused by {sup 153} Sm-EDTMP, combined with BrdU a thymidine analog; Efecto citotoxico y genotoxico causado por {sup 153} Sm-EDTMP, combinado con BrdU un analogo de timidina}
author = {Morales A, E, Ferro F, G, and Morales R, P}
abstractNote = {The ablation of the bone marrow previous to the transplant by means of radiation and chemical antineoplastics its affect indiscriminately to the healthy tissues and in particular those that are in proliferation. The objective of this work is to determine the effect of the incorporation from the BrdU to the DNA on the genotoxicity and cytotoxicity of the cells of the bone marrow caused by the radiopharmaceutical {sup 153}Sm-EDTMP. The genotoxicity was determined by the rate of erythrocytes polychromatic micro nucleates (EPC-MN) and the cytotoxicity by the frequency of EPC. Both parameters determined in peripheral blood after the BrdU administration and {sup 153}Sm-EDTMP. The combination of the BrdU and r1 radiopharmaceutical produced a bigger cytotoxicity that the radiation and the BrdU alone; on the other hand it produced a reduction of the EPC-MN produced by the radiation, suggesting that the cytotoxicity didn't allow the expression of the genotoxicity. (Author)}
place = {Mexico}
year = {2006}
month = {Jul}
}