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Study of abscopal radiation effects on multicellular organisms; Etudes sur les effets a distance dans les organismes multicellulaires irradies

Abstract

Amongst the lesions brought about by total body irradiation, two basically different types can be distinguished: those appearing in the area which has absorbed radiant energy and those emerging in areas remote from the irradiated tissues (abscopal effects). The abscopal effects are produced by toxic tissue breakdown products, which are removed by the bloodstream and interfere with particularly sensitive structures (radiotoxins). The radiotoxins mobilize other biologically active substances, interfering with the same tissues which may display abscopal effects. This is well established for the hormones of the adrenal cortex. Furthermore, important fractions of the radiotoxins are neutralized by the reticuloendothelial system. Temporary blockade of this system enhances the efficiency of radiotoxins and greatly increases mortality of the irradiated animals. One can therefore conclude that the reticuloendothelial system affords a natural defense against an essential reaction of total body irradiation: the effect of the radiotoxins. (author) [French] Les lesions consecutives a une irradiation peuvent etre classees en deux categories: celles qui se produisent au niveau du tissu irradie et celles qui apparaissent en dehors de celui-ci. Ces dernieres - appelees -'effets a distance'- sont dues a l'action de produits d'histolyse apparaissant au niveau du volume tissulaire ayant absorbe l'energie radiante, emportes  More>>
Authors:
Ludwig, F [1] 
  1. Commissariat a l'Energie Atomique, Saclay (France). Centre d'Etudes Nucleaires
Publication Date:
Jul 01, 1958
Product Type:
Technical Report
Report Number:
CEA-R-912
Resource Relation:
Other Information: 75 refs
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; ABSCOPAL RADIATION EFFECTS; ADRENAL GLANDS; ADRENALECTOMY; ASCITES TUMOR CELLS; BIOLOGICAL SHOCK; EHRLICH ASCITES TUMOR; GAMMA RADIATION; INTRAPERITONEAL INJECTION; INTRAVENOUS INJECTION; MICE; MORTALITY; PARABIOSIS; PHAGOCYTOSIS; RADIATION SYNDROME; RADIOTOXINS; RATS; RETICULOENDOTHELIAL SYSTEM; TIME DEPENDENCE; WHOLE-BODY IRRADIATION; X RADIATION
OSTI ID:
20890004
Research Organizations:
CEA Saclay, 91 - Gif-sur-Yvette (France)
Country of Origin:
France
Language:
French
Other Identifying Numbers:
TRN: FR07R0912054623
Availability:
Available from INIS in electronic form
Submitting Site:
FRN
Size:
48 pages
Announcement Date:
Aug 10, 2007

Citation Formats

Ludwig, F. Study of abscopal radiation effects on multicellular organisms; Etudes sur les effets a distance dans les organismes multicellulaires irradies. France: N. p., 1958. Web.
Ludwig, F. Study of abscopal radiation effects on multicellular organisms; Etudes sur les effets a distance dans les organismes multicellulaires irradies. France.
Ludwig, F. 1958. "Study of abscopal radiation effects on multicellular organisms; Etudes sur les effets a distance dans les organismes multicellulaires irradies." France.
@misc{etde_20890004,
title = {Study of abscopal radiation effects on multicellular organisms; Etudes sur les effets a distance dans les organismes multicellulaires irradies}
author = {Ludwig, F}
abstractNote = {Amongst the lesions brought about by total body irradiation, two basically different types can be distinguished: those appearing in the area which has absorbed radiant energy and those emerging in areas remote from the irradiated tissues (abscopal effects). The abscopal effects are produced by toxic tissue breakdown products, which are removed by the bloodstream and interfere with particularly sensitive structures (radiotoxins). The radiotoxins mobilize other biologically active substances, interfering with the same tissues which may display abscopal effects. This is well established for the hormones of the adrenal cortex. Furthermore, important fractions of the radiotoxins are neutralized by the reticuloendothelial system. Temporary blockade of this system enhances the efficiency of radiotoxins and greatly increases mortality of the irradiated animals. One can therefore conclude that the reticuloendothelial system affords a natural defense against an essential reaction of total body irradiation: the effect of the radiotoxins. (author) [French] Les lesions consecutives a une irradiation peuvent etre classees en deux categories: celles qui se produisent au niveau du tissu irradie et celles qui apparaissent en dehors de celui-ci. Ces dernieres - appelees -'effets a distance'- sont dues a l'action de produits d'histolyse apparaissant au niveau du volume tissulaire ayant absorbe l'energie radiante, emportes par le courant sanguin et agissant sur des structures specialement receptives (Radiotoxines). Ces corps provoquait, dans des structures eloignees du siege de l'action locale du rayonnement, la secretion d'autres corps biologiquement actifs, capables d'agir sur les memes tissus pouvant presenter des effets a distance, compliquant ainsi leur mecanisme. Ceci est etabli pour les corticosteroides. De plus, des fractions importantes des radiotoxines sont neutralisees par le systeme reticuloendothelial. Puisque le blocage de ce systeme prolonge non seulement l'action des radiotoxines mais compromet egalement la survie de l'organisme irradie, on peut conclure que la phagocytose reticuloendotheliale represente un moyen de defense naturel contre une consequence essentielle de l'irradiation, savoir l'action des radiotoxines. (auteur)}
place = {France}
year = {1958}
month = {Jul}
}