You need JavaScript to view this

Gestational trophoblastic disease: experience at a tertiary care hospital of sindh

Journal Article:

Abstract

To determine the frequency, clinical presentation and management outcomes of Gestational Trophoblastic Disease (GTD). The case records of all the gestational trophoblastic cases during study period were analyzed regarding their illness history, clinical examination, investigations, treatment and follow-up. The main outcomes were measured in terms of duration, antecedent pregnancy, investigations, treatment and the follow-up. There were a total of 1030 obstetric admissions during the study period, which included 23 cases of trophoblastic disease. Hence, frequency of GTD was 1 per 45 live births. Of these 23 cases, 19 (82.6%) patients had hydatidiform mole and 4 patients had malignant trophoblastic disease. Eight patients (34.7%) received chemotherapy while rest of the patients had suction evacuation and follow-up. Among all patients, 21 (91.3%) fully recovered and 2 (8.69%) died because of extensive disease; metastasis extending upto brain. Frequency of trophoblastic disease was high in this series compared to world and national literature. Therefore, emphasis should be on the early diagnosis of disease as proper management in the early stages strongly influences the outcome of disease. Suction evacuation and follow-up are ideal treatments for benign trophoblastic disease. (author)
Authors:
Khaskheli, M; Imdad, A; Baloch, S [1] 
  1. Liaquat Univ. of Medical and Health Sciences, Jamshoro (Pakistan). Dept. of Obstetrics and Gynaecology
Publication Date:
Feb 15, 2007
Product Type:
Journal Article
Resource Relation:
Journal Name: JCPSP. Journal of the College of Physicians and Surgeons Pakistan; Journal Volume: 17; Journal Issue: 2
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; CHEMOTHERAPY; DIAGNOSIS; FOLIC ACID; METASTASES; NEOPLASMS; PAKISTAN; SURGERY
OSTI ID:
20889494
Country of Origin:
Pakistan
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1022-386X; TRN: PK0700320054103
Submitting Site:
INIS
Size:
page(s) 81-83
Announcement Date:
Aug 13, 2007

Journal Article:

Citation Formats

Khaskheli, M, Imdad, A, and Baloch, S. Gestational trophoblastic disease: experience at a tertiary care hospital of sindh. Pakistan: N. p., 2007. Web.
Khaskheli, M, Imdad, A, & Baloch, S. Gestational trophoblastic disease: experience at a tertiary care hospital of sindh. Pakistan.
Khaskheli, M, Imdad, A, and Baloch, S. 2007. "Gestational trophoblastic disease: experience at a tertiary care hospital of sindh." Pakistan.
@misc{etde_20889494,
title = {Gestational trophoblastic disease: experience at a tertiary care hospital of sindh}
author = {Khaskheli, M, Imdad, A, and Baloch, S}
abstractNote = {To determine the frequency, clinical presentation and management outcomes of Gestational Trophoblastic Disease (GTD). The case records of all the gestational trophoblastic cases during study period were analyzed regarding their illness history, clinical examination, investigations, treatment and follow-up. The main outcomes were measured in terms of duration, antecedent pregnancy, investigations, treatment and the follow-up. There were a total of 1030 obstetric admissions during the study period, which included 23 cases of trophoblastic disease. Hence, frequency of GTD was 1 per 45 live births. Of these 23 cases, 19 (82.6%) patients had hydatidiform mole and 4 patients had malignant trophoblastic disease. Eight patients (34.7%) received chemotherapy while rest of the patients had suction evacuation and follow-up. Among all patients, 21 (91.3%) fully recovered and 2 (8.69%) died because of extensive disease; metastasis extending upto brain. Frequency of trophoblastic disease was high in this series compared to world and national literature. Therefore, emphasis should be on the early diagnosis of disease as proper management in the early stages strongly influences the outcome of disease. Suction evacuation and follow-up are ideal treatments for benign trophoblastic disease. (author)}
journal = {JCPSP. Journal of the College of Physicians and Surgeons Pakistan}
issue = {2}
volume = {17}
place = {Pakistan}
year = {2007}
month = {Feb}
}