You need JavaScript to view this

Long Term Follow-up of HIV-1 Exposed Children in Nairobi

Conference:

Abstract

Transmission of HIV-1 from an infected mother to her infant is the major route of transmission of this infection to children. In sub-Saharan Africa where heterosexual transmission of HIV is the commonest mode of spread, high prevalence of HIV infection in women of child bearing age is bound to lead to increased paediatric AIDS as a result of vertical transmission. In recognizing these epidemiological factors, the University of Nairobi HIV-1 Perinatal Transmission and Paediatric AIDS Project was initiated in 1986. Antenatal mothers attending Pumwani Maternity Hospital were enrolled during labour and screened for HIV-1 infection by ELISA. Those reacting positive were to participate in the study. An equal number of negative controls were also recruited. The mothers and babies of both groups were followed for varying periods over the next five years. A total of 360 babies born to HIV infected mothers and 360 babies born to HIV negative mothers were examined. The mortality rate observed in the HIV-1 exposed was substantially higher than that observed in controls (RR 2.8, 95% CI 1.3-6.1). Common causes of death among infected infants were pneumonia, measles, malaria, gastroenteritis, tuberculosis, and septicaemia. The five year survival was 85% among HIV infected children. Maternal risk  More>>
Authors:
Ndinya-Achola, J O; Datta, P; Maitha, G; [1]  Embree, J E; Kreiss, J K; Achola, P S; [2]  Holmes, K K; [3]  Plummer, F A [4] 
  1. Department of Microbiology, University of Nairobi, (Kenya)
  2. Health Department, Nairobi City Commission, Nairobi, (Kenya)
  3. Dept. of Medicine, Harboview Medical Centre, University of Washington, Seattle (United States)
  4. Dept. of Medical Microbiology, University of Manitoba (Canada)
Publication Date:
May 15, 1992
Product Type:
Conference
Resource Relation:
Conference: 13. Annual Medical Conference on Rational Use of Drugs, Nairobi (Kenya), 3-7 Feb 1992; Other Information: 3 tabs; graphs and tabs; Related Information: In: Proceedings of the Annual Medical Scientific Conference. Recent Advances in Medical Research with a Symposium on the Rational Use of Drugs, by Were, J.B.O.; Mutugi, M.W.; Githure, J.I. [Kenya Medical Research Institute, Nairobi (Kenya)] (eds.), 81 pages.
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; AIDS; CHILDREN; DIAGNOSIS; ENZYME IMMUNOASSAY; KENYA
OSTI ID:
20866900
Research Organizations:
Kenya Medical Research Institute, Nairobi (Kenya); Kenya Trypanosomiasis Research Institute, Nairobi (Kenya)
Country of Origin:
Kenya
Language:
English
Other Identifying Numbers:
Other: ISBN 9966-869-12-10; TRN: KE0700006034625
Availability:
Available from Kenya Medical Research Institute (KE), PO Box 54840. Tel. 254-02-722541, Nairobi, (KE);INIS
Submitting Site:
INIS
Size:
page(s) 18-20
Announcement Date:
May 24, 2007

Conference:

Citation Formats

Ndinya-Achola, J O, Datta, P, Maitha, G, Embree, J E, Kreiss, J K, Achola, P S, Holmes, K K, and Plummer, F A. Long Term Follow-up of HIV-1 Exposed Children in Nairobi. Kenya: N. p., 1992. Web.
Ndinya-Achola, J O, Datta, P, Maitha, G, Embree, J E, Kreiss, J K, Achola, P S, Holmes, K K, & Plummer, F A. Long Term Follow-up of HIV-1 Exposed Children in Nairobi. Kenya.
Ndinya-Achola, J O, Datta, P, Maitha, G, Embree, J E, Kreiss, J K, Achola, P S, Holmes, K K, and Plummer, F A. 1992. "Long Term Follow-up of HIV-1 Exposed Children in Nairobi." Kenya.
@misc{etde_20866900,
title = {Long Term Follow-up of HIV-1 Exposed Children in Nairobi}
author = {Ndinya-Achola, J O, Datta, P, Maitha, G, Embree, J E, Kreiss, J K, Achola, P S, Holmes, K K, and Plummer, F A}
abstractNote = {Transmission of HIV-1 from an infected mother to her infant is the major route of transmission of this infection to children. In sub-Saharan Africa where heterosexual transmission of HIV is the commonest mode of spread, high prevalence of HIV infection in women of child bearing age is bound to lead to increased paediatric AIDS as a result of vertical transmission. In recognizing these epidemiological factors, the University of Nairobi HIV-1 Perinatal Transmission and Paediatric AIDS Project was initiated in 1986. Antenatal mothers attending Pumwani Maternity Hospital were enrolled during labour and screened for HIV-1 infection by ELISA. Those reacting positive were to participate in the study. An equal number of negative controls were also recruited. The mothers and babies of both groups were followed for varying periods over the next five years. A total of 360 babies born to HIV infected mothers and 360 babies born to HIV negative mothers were examined. The mortality rate observed in the HIV-1 exposed was substantially higher than that observed in controls (RR 2.8, 95% CI 1.3-6.1). Common causes of death among infected infants were pneumonia, measles, malaria, gastroenteritis, tuberculosis, and septicaemia. The five year survival was 85% among HIV infected children. Maternal risk factors associated with transmission were marital status, duration of sexual activity and the age of the first intercourse.}
place = {Kenya}
year = {1992}
month = {May}
}