2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to produce a wide range of toxic and biochemical effects in experimental animals, including immunological dysfunctions, chloracne, tetragenecity and carcinogenesis. Recently, the potential impact of dioxins on neurological disorders with particular focus on attention deficit hyperactivity disorder (ADHD) are concerned. Although a lot of information is available from studies in rodents, not much is known of the low dose effects of TCDD in non-human primates. In higher animals, dioxins are metabolized slowly, as evidenced by the estimated TCDD half-life of 5.8 to 14.1 years. Therefore, it is necessary to investigate the long-term effects of TCDD on human health. Considering the pronounced species differences observed in some studies of TCDD, the studies using primates are needed for assessment of TCDD exposure on human health. We have been studying the metabolism and the effects of single administration of TCDD on pregnant monkey (F0) and F1 rhesus monkey. The focus of the present study is to study the effects of TCDD on signal transduction pathway-related protein levels in various organs, especially in liver and brain of F0 monkeys.
Ohta, Mari; Akema, Satoshi; Tsuzuki, Masami; Kubota, Shunichiro;  Korenaga, Tatsumi; Fukusato, Toshio;  Asaoka, Kazuo;  Murata, Nobuo;  Nomizu, Motoyoshi;  Arima, Akihiro 
- Tokyo Univ. (Japan)
- Teikyo Univ. of School of Medicine, Tokyo (Japan)
- Kyoto Univ. (Japan)
- Teikyo Univ. of School of Medicine, Kawasaki (Japan)
- Hokkaido Univ., Sapporo (Japan)
- Shin Nippon Biomedical Laboratories, Ltd., Kagoshima (Japan)