You need JavaScript to view this

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on signal transduction pathway-related protein expression in liver and cerebrum of rhesus monkey

Abstract

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to produce a wide range of toxic and biochemical effects in experimental animals, including immunological dysfunctions, chloracne, tetragenecity and carcinogenesis. Recently, the potential impact of dioxins on neurological disorders with particular focus on attention deficit hyperactivity disorder (ADHD) are concerned. Although a lot of information is available from studies in rodents, not much is known of the low dose effects of TCDD in non-human primates. In higher animals, dioxins are metabolized slowly, as evidenced by the estimated TCDD half-life of 5.8 to 14.1 years. Therefore, it is necessary to investigate the long-term effects of TCDD on human health. Considering the pronounced species differences observed in some studies of TCDD, the studies using primates are needed for assessment of TCDD exposure on human health. We have been studying the metabolism and the effects of single administration of TCDD on pregnant monkey (F0) and F1 rhesus monkey. The focus of the present study is to study the effects of TCDD on signal transduction pathway-related protein levels in various organs, especially in liver and brain of F0 monkeys.
Authors:
Ohta, Mari; Akema, Satoshi; Tsuzuki, Masami; Kubota, Shunichiro; [1]  Korenaga, Tatsumi; Fukusato, Toshio; [2]  Asaoka, Kazuo; [3]  Murata, Nobuo; [4]  Nomizu, Motoyoshi; [5]  Arima, Akihiro [6] 
  1. Tokyo Univ. (Japan)
  2. Teikyo Univ. of School of Medicine, Tokyo (Japan)
  3. Kyoto Univ. (Japan)
  4. Teikyo Univ. of School of Medicine, Kawasaki (Japan)
  5. Hokkaido Univ., Sapporo (Japan)
  6. Shin Nippon Biomedical Laboratories, Ltd., Kagoshima (Japan)
Publication Date:
Sep 15, 2004
Product Type:
Conference
Report Number:
ETDE-DE-1546
Resource Relation:
Conference: Dioxin 2004: 24. international symposium on halogenated environmental organic pollutants and POPs, Berlin (Germany), 6-10 Sep 2004; Related Information: In: Dioxin 2004: 24. international symposium on halogenated environmental organic pollutants and POPs. Proceedings, Organohalogen Compounds v. 66, 4035 pages.
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; DIOXIN; CHLORINATED AROMATIC HYDROCARBONS; TOXICITY; MACACUS; PREGNANCY; HEALTH HAZARDS; RISK ASSESSMENT; BIOELECTRICITY; NERVOUS SYSTEM; METABOLISM; PROTEINS; LIVER; BRAIN
Sponsoring Organizations:
Bundesmin. fuer Umwelt, Naturschutz und Reaktorsicherheit, Bonn (Germany)
OSTI ID:
20828336
Research Organizations:
Technische Univ. Berlin (Germany). Inst. fuer Technischen Umweltschutz
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Other: ISBN 3-928379-30-5; TRN: DE07G1183
Availability:
Available as CD-ROM; www.osti.gov/servlets/purl/20828336-nrQb5O/; Commercial reproduction prohibited; OSTI as DE20828336
Submitting Site:
DE
Size:
page(s) 3252-3257
Announcement Date:
Jan 29, 2007

Citation Formats

Ohta, Mari, Akema, Satoshi, Tsuzuki, Masami, Kubota, Shunichiro, Korenaga, Tatsumi, Fukusato, Toshio, Asaoka, Kazuo, Murata, Nobuo, Nomizu, Motoyoshi, and Arima, Akihiro. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on signal transduction pathway-related protein expression in liver and cerebrum of rhesus monkey. Germany: N. p., 2004. Web.
Ohta, Mari, Akema, Satoshi, Tsuzuki, Masami, Kubota, Shunichiro, Korenaga, Tatsumi, Fukusato, Toshio, Asaoka, Kazuo, Murata, Nobuo, Nomizu, Motoyoshi, & Arima, Akihiro. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on signal transduction pathway-related protein expression in liver and cerebrum of rhesus monkey. Germany.
Ohta, Mari, Akema, Satoshi, Tsuzuki, Masami, Kubota, Shunichiro, Korenaga, Tatsumi, Fukusato, Toshio, Asaoka, Kazuo, Murata, Nobuo, Nomizu, Motoyoshi, and Arima, Akihiro. 2004. "Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on signal transduction pathway-related protein expression in liver and cerebrum of rhesus monkey." Germany.
@misc{etde_20828336,
title = {Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on signal transduction pathway-related protein expression in liver and cerebrum of rhesus monkey}
author = {Ohta, Mari, Akema, Satoshi, Tsuzuki, Masami, Kubota, Shunichiro, Korenaga, Tatsumi, Fukusato, Toshio, Asaoka, Kazuo, Murata, Nobuo, Nomizu, Motoyoshi, and Arima, Akihiro}
abstractNote = {2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to produce a wide range of toxic and biochemical effects in experimental animals, including immunological dysfunctions, chloracne, tetragenecity and carcinogenesis. Recently, the potential impact of dioxins on neurological disorders with particular focus on attention deficit hyperactivity disorder (ADHD) are concerned. Although a lot of information is available from studies in rodents, not much is known of the low dose effects of TCDD in non-human primates. In higher animals, dioxins are metabolized slowly, as evidenced by the estimated TCDD half-life of 5.8 to 14.1 years. Therefore, it is necessary to investigate the long-term effects of TCDD on human health. Considering the pronounced species differences observed in some studies of TCDD, the studies using primates are needed for assessment of TCDD exposure on human health. We have been studying the metabolism and the effects of single administration of TCDD on pregnant monkey (F0) and F1 rhesus monkey. The focus of the present study is to study the effects of TCDD on signal transduction pathway-related protein levels in various organs, especially in liver and brain of F0 monkeys.}
place = {Germany}
year = {2004}
month = {Sep}
}