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Dietary exposure to the PCB mixture aroclor 1254 may compromise osmoregulation by altering central vasopressin release

Abstract

Despite the importance of systemic osmoregulation, the potential deleterious effects of persistent organochlorines, such as polychlorinated biphenyls (PCBs), on body fluid regulation has not been thoroughly investigated. In an effort to ameliorate this deficit, the current study explores the toxic effects of PCBs on osmoregulation, and in particular, on the activity of the magnocellular neuroendocrine cell (MNC) system of the hypothalamus. MNCs of the supraoptic nucleus (SON) release oxytocin (OXY) and vasopressin (VP) from terminals in the neurohypophysis in response to dehydration. The latter is released to effect water conservation in response to dehydration via its action upon the kidney and through extra-renal actions. MNCs also secrete VP from their cell bodies and dendrites locally i.e., into the extracellular space of the SON. Although it has been shown that both intranuclear and systemic release rise in response to dehydration the physiological significance of intranuclear release has not been fully elucidated. We chose to use voluntary ingestion as the route of PCB exposure since it is more reflective of natural exposure compared to ip injection. One unexpected observation that resulted from pilot studies using ip injection of PCBs was the deleterious effects of the vehicle (corn oil) resulting in pooling of  More>>
Authors:
Coburn, C G; [1]  Gillard, E; Curras-Collazo, M [2] 
  1. Environmental Toxicology, Univ. of California at Riverside, CA (United States)
  2. Cell Biology and Neuroscience, Univ. of California at Riverside, CA (United States)
Publication Date:
Sep 15, 2004
Product Type:
Conference
Report Number:
ETDE-DE-1546
Resource Relation:
Conference: Dioxin 2004: 24. international symposium on halogenated environmental organic pollutants and POPs, Berlin (Germany), 6-10 Sep 2004; Related Information: In: Dioxin 2004: 24. international symposium on halogenated environmental organic pollutants and POPs. Proceedings, Organohalogen Compounds v. 66, 4035 pages.
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; POLYCHLORINATED BIPHENYLS; INGESTION; RATS; BIOLOGICAL EFFECTS; HYPOTHALAMUS; HOMEOSTASIS; WATER; DEHYDRATION
Sponsoring Organizations:
Bundesmin. fuer Umwelt, Naturschutz und Reaktorsicherheit, Bonn (Germany)
OSTI ID:
20828309
Research Organizations:
Technische Univ. Berlin (Germany). Inst. fuer Technischen Umweltschutz
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Other: ISBN 3-928379-30-5; TRN: DE07G1210
Availability:
Available as CD-ROM; www.osti.gov/servlets/purl/20828309-F42ril/; Commercial reproduction prohibited; OSTI as DE20828309
Submitting Site:
DE
Size:
page(s) 3109-3115
Announcement Date:
Jan 27, 2007

Citation Formats

Coburn, C G, Gillard, E, and Curras-Collazo, M. Dietary exposure to the PCB mixture aroclor 1254 may compromise osmoregulation by altering central vasopressin release. Germany: N. p., 2004. Web.
Coburn, C G, Gillard, E, & Curras-Collazo, M. Dietary exposure to the PCB mixture aroclor 1254 may compromise osmoregulation by altering central vasopressin release. Germany.
Coburn, C G, Gillard, E, and Curras-Collazo, M. 2004. "Dietary exposure to the PCB mixture aroclor 1254 may compromise osmoregulation by altering central vasopressin release." Germany.
@misc{etde_20828309,
title = {Dietary exposure to the PCB mixture aroclor 1254 may compromise osmoregulation by altering central vasopressin release}
author = {Coburn, C G, Gillard, E, and Curras-Collazo, M}
abstractNote = {Despite the importance of systemic osmoregulation, the potential deleterious effects of persistent organochlorines, such as polychlorinated biphenyls (PCBs), on body fluid regulation has not been thoroughly investigated. In an effort to ameliorate this deficit, the current study explores the toxic effects of PCBs on osmoregulation, and in particular, on the activity of the magnocellular neuroendocrine cell (MNC) system of the hypothalamus. MNCs of the supraoptic nucleus (SON) release oxytocin (OXY) and vasopressin (VP) from terminals in the neurohypophysis in response to dehydration. The latter is released to effect water conservation in response to dehydration via its action upon the kidney and through extra-renal actions. MNCs also secrete VP from their cell bodies and dendrites locally i.e., into the extracellular space of the SON. Although it has been shown that both intranuclear and systemic release rise in response to dehydration the physiological significance of intranuclear release has not been fully elucidated. We chose to use voluntary ingestion as the route of PCB exposure since it is more reflective of natural exposure compared to ip injection. One unexpected observation that resulted from pilot studies using ip injection of PCBs was the deleterious effects of the vehicle (corn oil) resulting in pooling of lipid within the abdominal cavity, mottling of the liver, fatty liver and general discoloration of all abdominal viscera at time of sacrifice. Therefore, all work described in this series of experiments have employed voluntary ingestion of the toxin. Work described in this paper suggests that PCBs in concentrations reflecting realistic lifetime exposure levels may negatively impact homeostatic mechanisms responsible for body water balance by altering somatodendritic (intranuclear) VP secretion in response to dehydration in vivo. The downstream consequences of such influence is currently under investigation, and preliminary evidence suggests that the final output of the MNC system may be greatly exaggerated during physiological stress in PCB-exposed rats.}
place = {Germany}
year = {2004}
month = {Sep}
}